10,523 research outputs found

    Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion

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    Podoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had contradictory results. In the present study, it was hypothesized that the different locations of PDPNpositive cells may explain these varying results. The present study aimed to focus on PDPN expression at the edge of esophageal cancer cell nests. In order to analyze the clinical significance of this PDPN expression, immunohistochemistry was performed using esophageal cancer tissue microarrays. PDPN expression at the edge of the cancer cell nest was found to be significantly associated with invasion (P<0.05) and poor prognosis (P<0.001) in patients with cancer. To further investigate the role of PDPN expression in cancer cells, the PDPN gene was cloned and transfected into esophageal squamous cell carcinoma (ESCC) cell lines. PDPN expression was also knocked down using small interfering RNA. PDPNpositive cancer cells were found to exhibit invasion characteristics. Thus, PDPN expression at the edge of a cancer cell nest may indicate invasion and represent a poor prognostic factor for ESCCs.published_or_final_versio

    Two classes of nonlocal Evolution Equations related by a shared Traveling Wave Problem

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    We consider reaction-diffusion equations and Korteweg-de Vries-Burgers (KdVB) equations, i.e. scalar conservation laws with diffusive-dispersive regularization. We review the existence of traveling wave solutions for these two classes of evolution equations. For classical equations the traveling wave problem (TWP) for a local KdVB equation can be identified with the TWP for a reaction-diffusion equation. In this article we study this relationship for these two classes of evolution equations with nonlocal diffusion/dispersion. This connection is especially useful, if the TW equation is not studied directly, but the existence of a TWS is proven using one of the evolution equations instead. Finally, we present three models from fluid dynamics and discuss the TWP via its link to associated reaction-diffusion equations

    Measurement of the e+eπ+π\mathrm e^+\mathrm e^-\rightarrow\mathrm\pi^+\mathrm\pi^- Cross Section between 600 and 900 MeV Using Initial State Radiation

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    We extract the e+eπ+πe^+e^-\rightarrow \pi^+\pi^- cross section in the energy range between 600 and 900 MeV, exploiting the method of initial state radiation. A data set with an integrated luminosity of 2.93 fb1^{-1} taken at a center-of-mass energy of 3.773 GeV with the BESIII detector at the BEPCII collider is used. The cross section is measured with a systematic uncertainty of 0.9%. We extract the pion form factor Fπ2|F_\pi|^2 as well as the contribution of the measured cross section to the leading order hadronic vacuum polarization contribution to (g2)μ(g-2)_\mu. We find this value to be aμππ,LO(600900  MeV)=(368.2±2.5stat±3.3sys)1010a_\mu^{\pi\pi,\rm LO}(600-900\;\rm MeV) = (368.2 \pm 2.5_{\rm stat} \pm 3.3_{\rm sys})\cdot 10^{-10}.Comment: 14 pages, 7 figures, accepted by PL

    Measurement of the Matrix Elements for the Decays ηπ+ππ0\eta \rightarrow \pi^{+}\pi^{-}\pi^0 and η/ηπ0π0π0\eta/\eta^{\prime}\rightarrow\pi^0\pi^0\pi^0

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    Based on a sample of 1.31×1091.31 \times 10^9 J/ψJ/\psi events collected with the BESIII detector at the BEPCII collider, Dalitz plot analyses of selected 79,625 ηπ+ππ0\eta\rightarrow\pi^{+}\pi^{-}\pi^0 events, 33,908 ηπ0π0π0\eta\rightarrow\pi^0\pi^0\pi^0 events and 1,888 ηπ0π0π0\eta^{\prime}\rightarrow\pi^0\pi^0\pi^0 events are performed. The measured matrix elements of ηπ+ππ0\eta\rightarrow\pi^+\pi^-\pi^0 are in reasonable agreement with previous measurements. The Dalitz plot slope parameters of ηπ0π0π0\eta\rightarrow\pi^0\pi^0\pi^0 and ηπ0π0π0\eta^{\prime}\rightarrow\pi^0\pi^0\pi^0 are determined to be 0.055±0.014±0.004-0.055 \pm 0.014 \pm 0.004 and 0.640±0.046±0.047-0.640 \pm 0.046 \pm 0.047, respectively, where the first uncertainties are statistical and the second systematic. Both values are consistent with previous measurements, while the precision of the latter one is improved by a factor of three. Final state interactions are found to have an important role in those decays.Comment: 12 pages, 7 figure

    Measurement of B(ψ(3770)γχc1)\mathcal B(\psi(3770)\to\gamma \chi_{c1}) and search for ψ(3770)γχc2\psi(3770)\to\gamma \chi_{c2}

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    We report a measurement of the branching fraction of ψ(3770)γχc1\psi(3770)\to\gamma\chi_{c1} and search for the transition ψ(3770)γχc2\psi(3770)\rightarrow \gamma \chi_{c2} based on 2.92~fb1^{-1} of e+ee^+e^- data accumulated at s=3.773\sqrt{s}=3.773~GeV with the BESIII detector at the BEPCII collider. The measured branching fraction of ψ(3770)γχc1\psi(3770) \rightarrow \gamma \chi_{c1} is B(ψ(3770)γχc1)=(2.48±0.15±0.23)×103\mathcal B(\psi(3770) \rightarrow \gamma \chi_{c1})=(2.48 \pm 0.15 \pm 0.23) \times 10^{-3}, which is the most precise measurement to date. The upper limit on the branching fraction of ψ(3770)γχc2\psi(3770)\rightarrow \gamma \chi_{c2} at a 90%90\% confidence level is B(ψ(3770)γχc2)<0.64×103\mathcal B(\psi(3770) \rightarrow \gamma \chi_{c2})<0.64 \times 10^{-3}. The corresponding partial widths are Γ(ψ(3770)γχc1)=(67.5±4.1±6.7)\Gamma(\psi(3770) \to \gamma \chi_{c1}) =(67.5\pm 4.1\pm 6.7)~keV and Γ(ψ(3770)γχc2)<17.4\Gamma(\psi(3770) \to \gamma \chi_{c2}) < 17.4~keV
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