Ongoing Spillover of Hantaan and Gou Hantaviruses from Rodents Is Associated with Hemorrhagic Fever with Renal Syndrome (HFRS) in China

Peer reviewe

Synthesis and Characterization of a Pentiptycene-Derived Dual Oligoparaphenylene Nanohoop

Structural designs combining oligoparaphenylene-derived nanohoops with other functional organic building blocks should lead to novel molecular architectures with intriguing properties. Herein, we describe the synthesis of a pentiptycene-derived chiral dual nanohoop molecule with key steps including ring expansion through dianthracene cycloreversion and transannular [4+2] cycloaddition across a 64-membered macrocycle. The crystal structure of the nanohoop molecule displays an ordered packing pattern with long-range channels in the solid state. Furthermore, nonracemizable enantiomers of the nanohoop were obtained through resolution and exhibited promising chiroptical properties

Trace elements and lead isotopic composition of PM(10) in Lhasa, Tibet

This paper presents the first detailed investigation on airborne trace metals and their potential major sources at Lhasa, the largest city in Tibetan Plateau (TP). The whole year PM10 samples were collected during September 2007 and August 2008. The annual average concentration of PM10 in Lhasa was 51.8±42.5μgm-3, lower than those of major Asian cities. Distinct seasonal patterns were observed in PM10 concentration, with higher concentrations in winter, and lower in summer. The mean elemental concentrations were generally comparable with other urban areas, but significantly higher than those from a remote site in TP (i.e., Nam Co). Crustal elements, including Na, Mg, Al, K, Ca, Sc, Ti, V, Mn, Fe, As and Ba, had similar seasonal patterns in PM10, while other elements, such as Cr, Co, Ni, Cu, Zn, and Cd, had less distinct seasonal variations, suggesting more anthropogenic inputs of the latter group. The result of principle component analysis (PCA) on trace elements demonstrated that fugitive dusts, traffic emissions and waste incineration activities were probably the major sources of anthropogenic metals in the atmosphere at Lhasa. The Pb isotopic compositions revealed that the metal was mainly originated from nature background with a minor contribution from the cement factory. The data obtained in this study can be useful for making pollution control strategies in the city, and also valuable for trace element studies in other environmental medium, such as snow, ice core, and lake sediments in the TP region.Department of Civil and Environmental Engineerin

Synthesis of Oligoparaphenylene-Derived Nanohoops Employing an Anthracene Photodimerization-Cycloreversion Strategy

The century-old yet synthetically underexplored anthracene photodimerization-cycloreversion reactions have been employed as the key steps to access highly strained aromatic hydrocarbons. Herein we report the chemical syntheses of oligoparaphenylene-derived nanohoops in five steps or less featuring a rigid dianthracene synthon. The newly synthesized nanohoops display intriguing experimental and computational properties

Predictive Value of Nutritional Risk for All-Cause Death and Functional Outcomes in Chinese Elderly Patients with Acute Stroke: A 3-Year Follow-Up Study

Wen-Jie Cong,1,* Zhi-Peng Liu,2,* Yi-Xin Liang,2 Sheng-Lie Ye,2 Zhong-Ming Cai,2 Hao-Man Chen,2 Cheng-Wei Liao,2 Qun-Li Lin,3 Ren-Qian Feng,2 Xu-Dong Zhou,4 Yan-Zhi Wu,2 Le-Qiu Sun,5 Xue-Rong Huang,6 Man-Man Zhang,7 Gui-Qian Huang,8 Bei-Lei Zhu7 1Department of Acupuncture and Physiotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2The First Clinical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Department of Neurology, Yongjia People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Neurology, Pingyang People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China; 5Department of Neurology, Affiliated Yueqing Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 6Department of Neurology, Ruian People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China; 7Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang People’s Republic of China; 8School of Mental Health, Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bei-Lei Zhu, Tel +86 13567896076, Email [email protected]: To explore the predictive value of nutritional risk for all-cause death and functional outcomes among elderly acute stroke patients.Patients and Methods: A total of 479 elderly acute stroke patients were enrolled in this study. The nutritional risk of patients was screened by the GNRI and NRS-2002. The primary outcome was all-cause death, and the secondary outcome was poor prognosis defined as a modified Rankin Scale (mRS) score ≥ 3.Results: Based on the NRS-2002, patients with nutritional risk had a higher risk of all-cause death at 3 months (adjusted OR: 3.642, 95% CI 1.046~12.689) and at 3 years (adjusted OR: 2.266, 95% CI 1.259~4.076) and a higher risk of adverse functional outcomes at 3 months (adjusted OR: 2.748, 95% CI 1.518~4.972. Based on the GNRI, compared to those without nutritional risk, patients with mild malnutrition also had a higher risk of all-cause death at 3 months (adjusted OR: 7.186, 95% CI 1.550~33.315) and at 3 years (adjusted OR: 2.255, 95% CI 1.211~4.199) and a higher risk of adverse functional outcomes at 3 months (adjusted OR: 1.947, 95% CI 1.030~3.680), so patients with moderate and severe malnutrition had a higher risk of all-cause death at 3 months (adjusted OR: 6.535, 95% CI 1.380~30.945) and at 3 years (adjusted OR: 2.498, 95% CI 1.301~4.799) and a higher risk of adverse functional outcomes at 3 months (adjusted OR: 2.213, 95% CI 1.144~4.279).Conclusion: Nutritional risk increases the risk of poor short-term and long-term outcomes in elderly patients with acute stroke. For elderly stroke patients, we should pay attention to early nutritional risk screening, and effective intervention should be provided to improve the prognosis of such patients.Keywords: acute stroke, malnutrition, nutritional screening, all-cause death, GNRI, NRS-200