Screening uncalibrated priority pollutants by improved AHP-CRITIC method at development land

Unlisted uncalibrated pollutants in the industrial land of northeast China are continuously accumulating due to insufficient regulatory control, posing a serious threat to the ecological environment and human health. To address this challenge and begin to quantify the currently unlisted uncalibrated pollutants present in the industrial land in northeast China, 170 candidate pollutants were screened based on the literature research method. The Analytical Hierarchy Process (AHP) and the Criteria Importance Through Intercrieria Correlation (CRITIC) were utilized equally to screen for priority control of unlisted uncalibrated pollutants. For the categorical indicators, local modifications were implemented on the toxicity, persistence, and migratory indicators, fully considering the industrial distribution, environmental traits, and pollutant sources in northeast China. The grading standards of these indicators were refined in accordance with the relevant criteria and the availability of monitoring data collected from databases and predicted data by models. 11 types of uncalibrated priority pollutants were screened out using the comprehensive evaluation method and conducting cluster analysis based on total pollutant scores. The order of pollutants identified as candidates for prioritized control measures was as follows: perfluorooctanoic acid (PFOA)＞acrolein＞perfluorooctane sulfonate (PFOS)＞styrene＞perfluorobutanoic acid (PFBA)＞anthracene (Ant)＞methyl isocyanate (MIC)＞2,4-dimethylphenol＞hexachlorobutadiene (HCBD)＞2,6-dimethylphenol＞perfluorononanoic acid (PFNA). In particular, PFOA has the highest concern with 382 points. It poses long-term and serious potential hazards to the ecological environment and human health of industrial sites in northeast China. Thus, controlling such key pollutants is crucial for northeast China's environmental protection, and the current work supports the prioritization of chemicals for management or remediation.</p

Unique genotype-phenotype correlations within LAMA2-related limb girdle muscular dystrophy in Chinese patients

BackgroundLAMA2-related limb girdle muscular dystrophy (LGMD R23) is rare. The detailed clinical phenotypes and genetic information associated with LGMD R23 are unknown.MethodsWe conducted a retrospective cross-sectional and longitudinal study on 19 LGMD R23 patients.ResultsNormal early motor development was observed in 84.2% patients. Mild orthopedic complications were observed in 42.1% patients. 36.8% patients had seizures, which is unusually frequent in LGMD. Epilepsy was eventually diagnosed in 26.3% patients. 46.7% patients presented with motor neuropathy. Genetic analysis identified 29 pathogenic variants, with missense and frameshift variants being the most common. The mutant sites were mainly distributed in the N-terminal and G-like domains of laminin. The missense variants are distributed near the N-terminus (exons 3–11), whereas frameshift variants are distributed in exons 12–65. Five patients were diagnosed with epilepsy and all of them harbor at least one missense variants in exon 4. 71.4% variants of patients with motor neuropathy located in the LN domain.ConclusionsMissense variants in exon 4 maybe correlated with epilepsy and variants in the LN domain maybe correlated with motor neuropathy in Chinese patients. Our study expands the clinical and genetic spectrum caused by LAMA2 variations and provides novel genotype-phenotype correlations of LGMD R23

A Search for Light Fermionic Dark Matter Absorption on Electrons in PandaX-4T

We report a search on a sub-MeV fermionic dark matter absorbed by electrons with an outgoing active neutrino using the 0.63 tonne-year exposure collected by PandaX-4T liquid xenon experiment. No significant signals are observed over the expected background. The data are interpreted into limits to the effective couplings between such dark matter and electrons. For axial-vector or vector interactions, our sensitivity is competitive in comparison to existing astrophysical bounds on the decay of such dark matter into photon final states. In particular, we present the first direct detection limits for an axial-vector (vector) interaction which are the strongest in the mass range from 25 to 45 (35 to 50) keV/c$^2$

Search for Cosmic-ray Boosted Sub-MeV Dark-Matter-Electron Scattering in PandaX-4T

We report the first search for the elastic scatterings between cosmic-ray boosted sub-MeV dark matter and electrons in the PandaX-4T liquid xenon experiment. Sub-MeV dark matter particles can be accelerated by scattering with electrons in the cosmic rays and produce detectable electron recoil signals in the detector. Using the commissioning data from PandaX-4T of 0.63~tonne$\cdot$year exposure, we set new constraints on DM-electron scattering cross sections for DM masses ranging from 10~eV/$c^2$ to 3~keV/$c^2$.6 pages, 3 figure

Structural Design and Trajectory Analysis of Planetary Wheel Stirring Device

The agitator is a kind of general equipment that is widely used in industrial and agricultural production. It involves many fields such as petroleum, chemical industry, rubber and coatings. All of which aim at obtaining homogeneous materials, improving the service performance of materials or accelerating the reaction. Compared with the ordinary agitator, the planetary agitator has a wider agitating range. This article introduces the structure and working method of planetary wheel agitator. The mathematical model of the movement track of a point on the mixing shovel is established, an example model of planetary stirring is designed and verified by comparison between Adams software and MATLAB software. On the basis of this, the change law of motion trajectory and coverage rate is analyzed; In addition to this, the influence of speed ratio on speed distribution is analyzed by EDEM simulation, which provides reference for subsequent design improvement.</jats:p

Sustainable Urban Facilities Design Based on Emotional Narratives

Emotional narration can provide innovative ideas for sustainable urban facilities. The design of sustainable urban facilities starts from the concept of emotional design, focuses on improving the user’s experience, implements innovative design process, extends the product life cycle, utilizes new sustainable materials, combines emotional factors with product functions, and gets more citizens participate in the design process. The research result shows that the gradual emotional narration thinking change from a single dimension to multiple dimensions can promote the design innovation, upgrades service of urban public facilities, and enhances the connection between users and urban facilities. It can be seen that a series of sustainable urban facilities designed based on emotional narration can serve as effective carriers for communication between urban residents and the city. Sustainable urban facilities with humanistic care are dedicated to making urban residents realize they cannot only enjoy the urban facilities, but also participate in the creation of better social environment</jats:p