(3-Hydroxy-2-{[1-(2-oxidophenyl)ethyl­idene]amino-κ2 O,N}propanoato-κO 1)diphenyltin(IV)

In the title compound, [Sn(C6H5)2(C11H11NO4)], the tin(IV) atom is penta-coordinated in a distorted trigonal-bipyramidal SnC2NO2 geometry. In the crystal structure, inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. Weak C—H⋯O inter­actions further link the dimers into chains extending in [010]

1,5-Bis(1-phenyl­ethyl­idene)carbonohydrazide

In the title mol­ecule, C17H18N4O, the two phenyl rings form a dihedral angle of 18.15 (17)°. In the crystal, pairs of inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into centrosymmetric dimers. Weak inter­molecular C—H⋯O inter­actions further link the dimers into chains running along [010]

2-Amino-4-[4-(dimethyl­amino)­phen­yl]-5-oxo-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile

In the title mol­ecule, C18H19N3O2, the fused cyclo­hexenone and pyran rings adopt sofa conformations. Inter­molecular N—H⋯N and N—H⋯O hydrogen bonds link mol­ecules into corrugated layers parallel to the bc plane

N′-Cyclo­hexyl­idenebenzohydrazide

In the title compound, C13H16N2O, the cyclo­hexane ring adopts a chair conformation. In the crystal structure, inter­molecular N—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into chains propagating in [001]

1-(1-Phenyl­ethyl­idene)carbonohydrazide

The title compound, C9H12N4O, crystallizes with two independent mol­ecules in the asymmetric unit. In the crystal, inter­molecular N—H⋯O and N—H⋯N hydrogen bonds link the mol­ecules into paired ribbons propagated in [100]. The crystal studied was a twin (twin law 00/00/001) with a minor component of 25%

(E)-N′-[(2-Hydroxy-1-naphthyl)methyl­ene]benzohydrazide monohydrate

In the title compound, C18H14N2O2·H2O, the dihedral angle between the benzene ring and the naphthalene system is 5.18 (10)°. Intra­molecular N—H⋯O hydrogen bonds influence the molecular conformation. In the crystal, inter­molecular N—H⋯O and O—H⋯O hydrogen bonds are observed as well as π–π inter­actions between the phenyl ring and the substituted ring of the naphthalene [centroid–centroid distance = 3.676 (11) Å]

2-Amino-4-(4-meth­oxy­phen­yl)-5-oxo-5,6,7,8-tetra­hydro-4H-chromene-3-carbonitrile

The title compound, C17H16N2O3, crystallizes with two independent mol­ecules in the asymmetric unit. In both mol­ecules, the fused cyclo­hexenone ring adopts a sofa conformation. In the crystal, N—H⋯N and N—H⋯O hydrogen bonds link the mol­ecules into corrugated layers parallel to the (101) plane

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment