Cognitive control and discourse comprehension in schizophrenia.

Cognitive deficits across a wide range of domains have been consistently observed in schizophrenia and are linked to poor functional outcome (Green, 1996; Carter, 2006). Language abnormalities are among the most salient and include disorganized speech as well as deficits in comprehension. In this review, we aim to evaluate impairments of language processing in schizophrenia in relation to a domain-general control deficit. We first provide an overview of language comprehension in the healthy human brain, stressing the role of cognitive control processes, especially during discourse comprehension. We then discuss cognitive control deficits in schizophrenia, before turning to evidence suggesting that schizophrenia patients are particularly impaired at processing meaningful discourse as a result of deficits in control functions. We conclude that domain-general control mechanisms are impaired in schizophrenia and that during language comprehension this is most likely to result in difficulties during the processing of discourse-level context, which involves integrating and maintaining multiple levels of meaning. Finally, we predict that language comprehension in schizophrenia patients will be most impaired during discourse processing. We further suggest that discourse comprehension problems in schizophrenia might be mitigated when conflicting information is absent and strong relations amongst individual words are present in the discourse context."There is no "centre of Speech" in the brain any more than there is a faculty of Speech in the mind.The entire brain, more or less, is at work in a man who uses language"William JamesFrom The Principles of Psychology, 1890"The mind in dementia praecox is like an orchestra without a conductor"Kraepelin, 1919

Protein crystal growth tray assembly

A protein crystal growth tray assembly includes a tray that has a plurality of individual crystal growth chambers. Each chamber has a movable pedestal which carries a protein crystal growth compartment at an upper end. The several pedestals for each tray assembly are ganged together for concurrent movement so that the solutions in the various pedestal growth compartments can be separated from the solutions in the tray's growth chambers until the experiment is to be activated

Fields in Nonaffine Bundles. I. The general bitensorially covariant differentiation procedure

The standard covariant differentiation procedure for fields in vector bundles is generalised so as to be applicable to fields in general nonaffine bundles in which the fibres may have an arbitrary nonlinear structure. In addition to the usual requirement that the base space should be flat or endowed with its own linear connection, and that there should be an ordinary gauge connection on the bundle, it is necessary to require also that there should be an intrinsic, bundle-group invariant connection on the fibre space. The procedure is based on the use of an appropriate primary-field (i.e. section) independent connector that is constructed in terms of the natural fibre-tangent-vector realisation of the gauge connection. The application to gauged harmonic mappings will be described in a following article.Comment: 17 page Latex file with some minor misprint corrections and added color for article originally published in black and whit

Physics at the B Factories

We review recent progress at the two $e^+ e^-$ B factories. The first measurement of CP violation and the prospects for measuring all the angles of the unitarity triangle are discussed.Comment: To appear in the Proceedings of From the Smallest to the Largest Distances, a conference in honor of Tranh Thanh Van in Moscow, Russi

Transition to adult services for children and young people with palliative care needs : a systematic review

Objective: To evaluate the evidence on the transition process from child to adult services for young people with palliative care needs. Design: Systematic review Setting: Child and adult services and interface between healthcare providers. Patients: Young people aged 13 to 24 years with palliative care conditions in the process of transition. Main outcome measures: Young people and their families’ experiences of transition, the process of transition between services and its impact on continuity of care, and models of good practice. Results: 92 studies included. Papers on transition services were of variable quality when applied to palliative care contexts. Most focused on common life threatening and life limiting conditions. No standardised transition programme identified and most guidelines used to develop transition services were not evidence based. Most studies on transition programmes were predominantly condition-specific (e.g. cystic fibrosis, cancer) services. Cystic fibrosis services offered high quality transition with the most robust empirical evaluation. There were differing condition-dependent viewpoints on when transition should occur but agreement on major principles guiding transition planning and probable barriers. There was evidence of poor continuity between child and adult providers with most originating from within child settings. Conclusions: Palliative care was not, in itself, a useful concept for locating transition-related evidence. It is not possible to evaluate the merits of the various transition models for palliative care contexts, or their effects on continuity of care, as there are no long-term outcome data to measure their effectiveness. Use of validated outcome measures would facilitate research and service development

Shock propagation and stability in causal dissipative hydrodynamics

We studied the shock propagation and its stability with the causal dissipative hydrodynamics in 1+1 dimensional systems. We show that the presence of the usual viscosity is not enough to stabilize the solution. This problem is solved by introducing an additional viscosity which is related to the coarse-graining scale of the theory.Comment: 14 pages, 16 figure

EXPLAINING INTERNATIONAL DIFFERENCES IN GENETICALLY MODIFIED FOOD LABELING REGULATIONS

Replaced with revised version of paper 07/13/04.Food Consumption/Nutrition/Food Safety,

Economic and Environmental Impacts of Adoption of Genetically Modified Rice in California

Crop Production/Industries, Research and Development/Tech Change/Emerging Technologies,

Dynamics of cosmic strings and springs; a covariant formulation

A general family of charge-current carrying cosmic string models is investigated. In the special case of circular configurations in arbitrary axially symmetric gravitational and electromagnetic backgrounds the dynamics is determined by simple point particle Hamiltonians. A certain "duality" transformation relates our results to previous ones, obtained by Carter et. al., for an infinitely long open stationary string in an arbitrary stationary background.Comment: 11 pages, Latex, Nordita preprint 93/28

Fermionic massive modes along cosmic strings

The influence on cosmic string dynamics of fermionic massive bound states propagating in the vortex, and getting their mass only from coupling to the string forming Higgs field, is studied. Such massive fermionic currents are numerically found to exist for a wide range of model parameters and seen to modify drastically the usual string dynamics coming from the zero mode currents alone. In particular, by means of a quantization procedure, a new equation of state describing cosmic strings with any kind of fermionic current, massive or massless, is derived and found to involve, at least, one state parameter per trapped fermion species. This equation of state exhibits transitions from subsonic to supersonic regimes while the massive modes are filled.Comment: 27 pages, 15 figures, uses ReVTeX. Shortened version, accepted for publication in Phys. Rev.