19,332 research outputs found

    A Flexible and Secure Deployment Framework for Distributed Applications

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    This paper describes an implemented system which is designed to support the deployment of applications offering distributed services, comprising a number of distributed components. This is achieved by creating high level placement and topology descriptions which drive tools that deploy applications consisting of components running on multiple hosts. The system addresses issues of heterogeneity by providing abstractions over host-specific attributes yielding a homogeneous run-time environment into which components may be deployed. The run-time environments provide secure binding mechanisms that permit deployed components to bind to stored data and services on the hosts on which they are running.Comment: 2nd International Working Conference on Component Deployment (CD 2004), Edinburgh, Scotlan

    The inferior caval vein draining into the left atrial cavity : a rare case

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    The inferior vena cava (IVC) draining into the left atrium (LA) is exceedingly rare in the setting of the usual atrial arrangement (situs solitus). This article describes a patient with this unique anomaly, and its repair.peer-reviewe

    Evocative computing – creating meaningful lasting experiences in connecting with the past

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    We present an approach – evocative computing – that demonstrates how ‘at hand’ technologies can be ‘picked up’ and used by people to create meaningful and lasting experiences, through connecting and interacting with the past. The approach is instantiated here through a suite of interactive technologies configured for an indoor-outdoor setting that enables groups to explore, discover and research the history and background of a public cemetery. We report on a two-part study where different groups visited the cemetery and interacted with the digital tools and resources. During their activities serendipitous uses of the technology led to connections being made between personal memo-ries and ongoing activities. Furthermore, these experiences were found to be long-lasting; a follow-up study, one year later, showed them to be highly memorable, and in some cases leading participants to take up new directions in their work. We discuss the value of evocative computing for enriching user experiences and engagement with heritage practices

    The influence of baryons on the mass distribution of dark matter halos

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    Using a set of high-resolution N-body/SPH cosmological simulations with identical initial conditions but run with different numerical setups, we investigate the influence of baryonic matter on the mass distribution of dark halos when radiative cooling is NOT included. We compare the concentration parameters of about 400 massive halos with virial mass from 101310^{13} \Msun to 7.1×10147.1 \times 10^{14} \Msun. We find that the concentration parameters for the total mass and dark matter distributions in non radiative simulations are on average larger by ~3% and 10% than those in a pure dark matter simulation. Our results indicate that the total mass density profile is little affected by a hot gas component in the simulations. After carefully excluding the effects of resolutions and spurious two-body heating between dark matter and gas particles, we conclude that the increase of the dark matter concentration parameters is due to interactions between baryons and dark matter. We demonstrate this with the aid of idealized simulations of two-body mergers. The results of individual halos simulated with different mass resolutions show that the gas profiles of densities, temperature and entropy are subjects of mass resolution of SPH particles. In particular, we find that in the inner parts of halos, as the SPH resolution increases the gas density becomes higher but both the entropy and temperature decrease.Comment: 8 pages, 6 figures, 1 table, ApJ in press (v652n1); updated to match with the being published versio

    Three-Dimensionally Engineered Normal Human Lung Tissue-Like Assemblies: Target Tissues for Human Respiratory Viral Infections

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    In vitro three-dimensional (3D) human lung epithelio-mesenchymal tissue-like assemblies (3D hLEM TLAs) from this point forward referred to as TLAs were engineered in Rotating Wall Vessel (RWV) technology to mimic the characteristics of in vivo tissues thus providing a tool to study human respiratory viruses and host cell interactions. The TLAs were bioengineered onto collagen-coated cyclodextran microcarriers using primary human mesenchymal bronchial-tracheal cells (HBTC) as the foundation matrix and an adult human bronchial epithelial immortalized cell line (BEAS-2B) as the overlying component. The resulting TLAs share significant characteristics with in vivo human respiratory epithelium including polarization, tight junctions, desmosomes, and microvilli. The presence of tissue-like differentiation markers including villin, keratins, and specific lung epithelium markers, as well as the production of tissue mucin, further confirm these TLAs differentiated into tissues functionally similar to in vivo tissues. Increasing virus titers for human respiratory syncytial virus (wtRSVA2) and the detection of membrane bound glycoproteins over time confirm productive infection with the virus. Therefore, we assert TLAs mimic aspects of the human respiratory epithelium and provide a unique capability to study the interactions of respiratory viruses and their primary target tissue independent of the host s immune system

    Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review

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    Background The rehabilitation of knee osteoarthritis often includes electrotherapeutic modalities as well as advice and exercise. One commonly used modality is pulsed electromagnetic field therapy (PEMF). PEMF uses electro magnetically generated fields to promote tissue repair and healing rates. Its equivocal benefit over placebo treatment has been previously suggested however recently a number of randomised controlled trials have been published that have allowed a systematic review to be conducted. Methods A systematic review of the literature from 1966 to 2005 was undertaken. Relevant computerised bibliographic databases were searched and papers reviewed independently by two reviewers for quality using validated criteria for assessment. The key outcomes of pain and functional disability were analysed with weighted and standardised mean differences being calculated. Results Five randomised controlled trials comparing PEMF with placebo were identified. The weighted mean differences of the five papers for improvement in pain and function, were small and their 95% confidence intervals included the null. Conclusion This systematic review provides further evidence that PEMF has little value in the management of knee osteoarthritis. There appears to be clear evidence for the recommendation that PEMF does not significantly reduce the pain of knee osteoarthritis

    The SEGUE Stellar Parameter Pipeline. IV. Validation with an Extended Sample of Galactic Globular and Open Clusters

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    Spectroscopic and photometric data for likely member stars of five Galactic globular clusters (M3, M53, M71, M92, and NGC 5053) and three open clusters (M35, NGC 2158, and NGC 6791) are processed by the current version of the SEGUE Stellar Parameter Pipeline (SSPP), in order to determine estimates of metallicities and radial velocities for the clusters. These results are then compared to values from the literature. We find that the mean metallicity () and mean radial velocity () estimates for each cluster are almost all within 2{\sigma} of the adopted literature values; most are within 1{\sigma}. We also demonstrate that the new version of the SSPP achieves small, but noteworthy, improvements in estimates at the extrema of the cluster metallicity range, as compared to a previous version of the pipeline software. These results provide additional confidence in the application of the SSPP for studies of the abundances and kinematics of stellar populations in the Galaxy.Comment: 98 pages, 31 figures; accepted for publication in A

    Holography in asymptotically flat space-times and the BMS group

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    In a previous paper (hep-th/0306142) we have started to explore the holographic principle in the case of asymptotically flat space-times and analyzed in particular different aspects of the Bondi-Metzner-Sachs (BMS) group, namely the asymptotic symmetry group of any asymptotically flat space-time. We continue this investigation in this paper. Having in mind a S-matrix approach with future and past null infinity playing the role of holographic screens on which the BMS group acts, we connect the IR sectors of the gravitational field with the representation theory of the BMS group. We analyze the (complicated) mapping between bulk and boundary symmetries pointing out differences with respect to the AdS/CFT set up. Finally we construct a BMS phase space and a free hamiltonian for fields transforming w.r.t BMS representations. The last step is supposed to be an explorative investigation of the boundary data living on the degenerate null manifold at infinity.Comment: 31 pages, several changes in section 3 and 7 and references update
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