Thermodynamics of Lithium Intercalation into Graphites and Disordered Carbons

The temperature dependence of the open-circuit potential of lithium half-cells was measured for electrodes of carbon materials having different amounts of structural disorder. The entropy of lithium intercalation, DeltaS, and enthalpy of intercalation, DeltaH, were determined over a broad range of lithium concentrations. For the disordered carbons, DeltaS is small. For graphite, an initially large DeltaS decreases with lithium concentration, becomes negative, and then shows two plateaus associated with the formation of intercalation compounds. For all carbons DeltaH is negative, and decreases in magnitude with increased lithium concentration. For lithium concentrations less than x = 0.5 in LixC6, for the disordered carbons the magnitude of DeltaH is significantly more negative than for graphite (i.e., intercalation is more exothermic). The measurements of DeltaH provide an energy spectrum of chemical environments for lithium. This spectrum can be used to understand some of the concentration dependence of configurational entropy, but the negative values of DeltaS require another contribution to entropy, perhaps vibrational in origin

Pro-oxidant effect of ALA is implicated in mitochondrial dysfunction of HepG2 cells

Heme biosynthesis begins in the mitochondrion with the formation of delta-aminolevulinic acid (ALA). In acute intermittent porphyria, hereditary tyrosinemia type I and lead poisoning patients, ALA is accumulated in plasma and in organs, especially the liver. These diseases are also associated with neuromuscular dysfunction and increased incidence of hepatocellular carcinoma. Many studies suggest that this damage may originate from ALA-induced oxidative stress following its accumulation. Using the MnSOD as an oxidative stress marker, we showed here that ALA treatment of cultured cells induced ROS production, increasing with ALA concentration. The mitochondrial energetic function of ALA-treated HepG2 cells was further explored. Mitochondrial respiration and ATP content were reduced compared to control cells. For the 300 μM treatment, ALA induced a mitochondrial mass decrease and a mitochondrial network imbalance although neither necrosis nor apoptosis were observed. The up regulation of PGC-1, Tfam and ND5 genes was also found; these genes encode mitochondrial proteins involved in mitochondrial biogenesis activation and OXPHOS function. We propose that ALA may constitute an internal bioenergetic signal, which initiates a coordinated upregulation of respiratory genes, which ultimately drives mitochondrial metabolic adaptation within cells. The addition of an antioxidant, Manganese(III) tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), resulted in improvement of maximal respiratory chain capacity with 300 μM ALA. Our results suggest that mitochondria, an ALA-production site, are more sensitive to pro-oxidant effect of ALA, and may be directly involved in pathophysiology of patients with inherited or acquired porphyria

The GALEX/S4G UV-IR color-color diagram: Catching spiral galaxies away from the Blue Sequence

We obtained GALEX FUV, NUV, and Spitzer/IRAC 3.6$\mu$m photometry for > 2000 galaxies, available for 90% of the S4G sample. We find a very tight "GALEX Blue Sequence (GBS)" in the (FUV-NUV) versus (NUV-[3.6]) color-color diagram which is populated by irregular and spiral galaxies, and is mainly driven by changes in the formation timescale ($\tau$) and a degeneracy between $\tau$ and dust reddening. The tightness of the GBS provides an unprecedented way of identifying star-forming galaxies and objects that are just evolving to (or from) what we call the "GALEX Green Valley (GGV)". At the red end of the GBS, at (NUV-[3.6]) > 5, we find a wider "GALEX Red Sequence (GRS)" mostly populated by E/S0 galaxies that has a perpendicular slope to that of the GBS and of the optical red sequence. We find no such dichotomy in terms of stellar mass (measured by $\rm{M}_{[3.6]}$), since both massive ($M_{\star} > 10^{11} M_{\odot}$) blue and red sequence galaxies are identified. The type that is proportionally more often found in the GGV are the S0-Sa's and most of these are located in high-density environments. We discuss evolutionary models of galaxies that show a rapid transition from the blue to the red sequence on timescale of $10^{8}$years.Comment: 7 pages, 4 figures, 1 table. Accepted for publication in ApJ

The GALEX/S(4)G Surface Brightness and Color Profiles Catalog. I. Surface Photometry and Color Gradients of Galaxies

We present new spatially resolved surface photometry in the far-ultraviolet (FUV) and near-ultraviolet (NUV) from images obtained by the Galaxy Evolution Explorer (GALEX) and IRAC1 (3.6 mu m) photometry from the Spitzer Survey of Stellar Structure in Galaxies (S(4)G). We analyze the radial surface brightness profiles mu(FUV), mu(NUV), and mu[3.6], as well as the radial profiles of (FUV - NUV), (NUV -[3.6]), and (FUV -[3.6]) colors in 1931 nearby galaxies (z < 0.01). The analysis of the 3.6 mu m surface brightness profiles also allows us to separate the bulge and disk components in a quasi-automatic way and to compare their light and color distribution with those predicted by the chemo-spectrophotometric models for the evolution of galaxy disks of Boissier & Prantzos. The exponential disk component is best isolated by setting an inner radial cutoff and an upper surface brightness limit in stellar mass surface density. The best-fitting models to the measured scale length and central surface brightness values yield distributions of spin and circular velocity within a factor of two of those obtained via direct kinematic measurements. We find that at a surface brightness fainter than mu([3.6]) = 20.89 mag arcsec(-2), or below 3 x 10(8) M-circle dot kpc(-2) in stellar mass surface density, the average specific star formation rate (sSFR) for star-forming and quiescent galaxies remains relatively flat with radius. However, a large fraction of GALEX Green Valley galaxies show a radial decrease in sSFR. This behavior suggests that an outside-in damping mechanism, possibly related to environmental effects, could be testimony of an early evolution of galaxies from the blue sequence of star-forming galaxies toward the red sequence of quiescent galaxies

Si doped T6 carbon structure as an anode material for Li-ion batteries: An ab initio study

First-principles calculations are performed to identify the pristine and Si doped 3D metallic T6 carbon structure (having both sp(2) and sp(3) type hybridization) as a new carbon based anode material. The pi electron of C-2 atoms (sp2 bonded) forms an out of plane network that helps to capture the Li atom. The highest Li storage capacity of Si doped T6 structure with conformation Li1.7Si1C5 produces theoretical specific capacity of 632 mAh/g which substantially exceeding than graphite. Also, open-circuit voltage (OCV) with respect to Li metal shows large negative when compared to the pristine T6 structure. This indicates modifications in terms of chemical properties are required in anode materials for practical application. Among various doped (Si, Ge, Sn, B, N) configuration, Si doped T6 structure provides a stable positive OCV for high Li concentrations. Likewise, volume expansion study also shows Si doped T6 structure is more stable with less pulverization and substantial capacity losses in comparison with graphite and silicon as an anode materials. Overall, mixed hybridized (sp(2) + sp(3)) Si doped T6 structure can become a superior anode material than present sp2 hybridized graphite and sp(3) hybridized Si structure for modern Lithium ion batteries.ope

A common variant near TGFBR3 is associated with primary open angle glaucoma

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution.We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10−33), we observed one SNP showing significant association to POAG (CDC7–TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10−8). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis

Communication of pharmacogenetic research results to HIV-infected treated patients: standpoints of professionals and patients.

International audienceThe aim of pharmacogenetic studies is to adapt therapeutic strategies to individual genetic profiles, thus maximising their efficacy and minimising the likelihood of adverse side effects. Since the advent of personalised medicine, the issue of communicating research results to participants has become increasingly important. We addressed this question in the context of HIV infection, as patients and associations are particularly concerned by research and therapeutic advances. We explored the standpoints of both research professionals and participants involved in a pharmacogenetic study conducted in a cohort of HIV-infected patients. The setting of the research protocol was followed over a 2-year period. Participants' standpoints were collected through a questionnaire and interviews were conducted with research professionals. Of 125 participants, 76% wished to receive individual results and 71% wished to receive collective results; 39% did not know when results might be expected. Communication of global research results is a principle that is generally accepted by professionals. Concerning individual feedback, the professionals felt that it was necessary if it could be of direct benefit to the participant, but they expressed doubts for situations with no recognised benefit. Our results highlight the necessity to consider this issue in greater detail. We suggest the need to anticipate the debates concerning individual feedback, to differentiate between situations and the importance of further investigations on the opportunities and modalities of communication. Finally, our work emphasised the opposite pressures between the pursuit of scientific knowledge and the therapeutic orientation of clinical trials

First Measurement of the Ti (e,e′) X Cross Section at Jefferson Lab

To probe CP violation in the leptonic sector using GeV energy neutrino beams in current and future experiments using argon detectors, precise models of the complex underlying neutrino and antineutrino interactions are needed. The E12-14-012 experiment at Jefferson Lab Hall A was designed to perform a combined analysis of inclusive and exclusive electron scatterings on both argon (N=22) and titanium (Z=22) nuclei using GeV-energy electron beams. The measurement on titanium nucleus provides essential information to understand the neutrino scattering on argon, large contribution to which comes from scattering off neutrons. Here we report the first experimental study of electron-titanium scattering as double-differential cross section at beam energy E=2.222 GeV and electron-scattering angle θ=15.541^{∘}, measured over a broad range of energy transfer, spanning the kinematical regions in which quasielastic scattering and delta production are the dominant reaction mechanisms. The data provide valuable new information needed to develop accurate theoretical models of the electromagnetic and weak cross sections of these complex nuclei in the kinematic regime of interest to neutrino experiments.National Science Foundation (U.S.) (CAREER Grant PHY-1352106

Galactic bulges from Hubble Space Telescope NICMOS observations: the lack of r^{1/4} bulges

We use HST near-infrared imaging to explore the shapes of the surface brightness profiles of bulges of S0-Sbc galaxies at high resolution. Modeling extends to the outer bulge via bulge-disk decompositions of combined HST - ground based profiles. Compact, central unresolved components similar to those reported by others are found in ~84% of the sample. We also detect a moderate frequency (~34%) of nuclear components with exponential profiles which may be disks or bars. Adopting the S\'ersic r^{1/n} functional form for the bulge, none of the bulges have an r^{1/4} behaviour; derived S\'ersic shape-indices are = 1.7 \pm 0.7. For the same sample, fits to NIR ground-based profiles yield S\'ersic indices up to n = 4-6. The high-$n$ of ground-based profiles are a result of nuclear point sources blending with the bulge extended light due to seeing. The low S\'ersic indices are not expected from merger violent relaxation, and argue against significant merger growth for most bulges.Comment: 4 pages, 3 figures, accepted for the Astrophysical Journal Letter