Controlled Anchoring of Iron-Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core@Shell Organic-Inorganic Nanocomposites for Magneto-Scaffolds

Composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and polymers are largely present in modern (bio)materials. However, while SPIONs embedded in polymer matrices are classically reported, the mechanical and degradation properties of the polymer scaffold are impacted by the SPIONs. Therefore, the controlled anchoring of SPIONs onto polymer surfaces is still a major challenge. Herein, we propose an efficient strategy for the direct and uniform anchoring of SPIONs on the surface of functionalized-polylactide (PLA) nanofibers via a simple free ligand exchange procedure to design PLA@SPIONs core@shell nanocomposites. The resulting PLA@SPIONs hybrid biomaterials are characterized by electron microscopy (SEM and TEM) and EDXS analysis, to probe the morphology and detect elements present at the organic/inorganic interface, respectively. A monolayer of SPIONs with a complete and homogeneous coverage is observed on the surface of PLA nanofibers. Magnetization experiments show that magnetic properties of the nanoparticles are well-preserved after their grafting on the PLA fibers and that the size of the nanoparticles does not change. The absence of cytotoxicity, combined with a high sensitivity of detection in MRI both in vitro and in vivo make these hybrid nanocomposites attractive for the development of magnetic biomaterials for biomedical applications

Effect of FeO on the formation of spinel phases and chromium distribution in the CaO-SiO2-MgO-Al2O3-Cr2O3 system

Synthetic slag samples of the CaO-SiO2-MgO-Al2O3-Cr2O3 system were obtained to clarify the effect of FeO on the formation of spinel phases and Cr distribution. X-ray diffraction (XRD) and scanning electron microscopy (SEM) equipped with energy-dispersive spectroscopy (EDS), as well as the thermodynamic software FactSage 6.2, were used for sample characterization. The results show that the addition of FeO can decrease the viscosity of molten slag and the precipitation temperatures of melilite and merwinite. The solidus temperature significantly decreases from 1400 to 1250 degrees C with the increase of FeO content from 0wt% to 6wt%. The addition of FeO could enhance the content of Cr in spinel phases and reduce the content of Cr in soluble minerals, such as merwinite, melilite, and dicalcium silicate. Hence, the addition of FeO is conducive to decreasing Cr leaching.Validerad; 2013; 20130411 (andbra

P-123 CLINICAL COURSE OF PATIENTS WITH CHOLESTATIC LIVER DISEASES IN A LIVER TRANSPLANT CENTER

Conflict of interest: No Introduction and Objectives: Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are immune-mediated cholestatic liver diseases, in which inflammation and/or fibrosis result in progressive destrucción of the bile duct. In their clinical course they evolve to cirrhosis and its complications.The objective was to describe the clinical and evolutionary characteristics and long-term survival in patients with cholestatic liver diseases (CLD). Patients / Materials and Methods: Descriptive, longitudinal and ambispective study, in patients with cholestatic liver diseases seen in the hepatology clinic of the Medical Surgical Research Center, between 2000 and 2024, with an average follow-up of 6 years (minimum of 1 and maximum of 14). Patients with PBC or PSC who received treatment with ursodeoxycholic acid and quarterly evaluations were included.The main variables were: initial stage, complications, response to treatment and clinical evolution. The data were processed with the SPSS statistical package version 22.0 on Windows; The analysis was performed by calculating the mean, standard deviation and percentage, and for survival the Kaplan-Meier method was used with a 95% confidence interval. Results and Discussion: Of 44 patients studied, the most frequent entity was PBC (58.8%). Half of the patients had cirrhosis at the time of diagnosis. Ascites was the most frequent complication (40.9%) and highlighted the insertion of cholangiocarcinoma in 50% of patients with PSC. Most patients had no response to treatment: PBC (61.8%) / PSC (80%). Disease progression was greater in PSC and survival was lower in these patients: 20% at six years. Conclusions: The clinical course of patients with cholestatic liver diseases was determined by the progression of the disease. Patients with PSC had a more torpid evolution, which led to poor survival in long-term follow-up