Convergence Analysis of the Variance in Gaussian Belief Propagation

It is known that Gaussian belief propagation (BP) is a low-complexity algorithm for (approximately) computing the marginal distribution of a high dimensional Gaussian distribu- tion. However, in loopy factor graph, it is important to determine whether Gaussian BP converges. In general, the convergence conditions for Gaussian BP variances and means are not nec- essarily the same, and this paper focuses on the convergence condition of Gaussian BP variances. In particular, by describing the message-passing process of Gaussian BP as a set of updating functions, the necessary and sufficient convergence conditions of Gaussian BP variances are derived under both synchronous and asynchronous schedulings, with the converged variances proved to be independent of the initialization as long as it is chosen from the proposed set. The necessary and sufficient convergence condition is further expressed in the form of a semi-definite programming (SDP) optimization problem, thus can be verified more efficiently compared to the existing convergence condition based on compu- tation tree. The relationship between the proposed convergence condition and the existing one based on computation tree is also established analytically. Numerical examples are presented to corroborate the established theories.published_or_final_versio

On Convergence Conditions of Gaussian Belief Propagation

In order to compute the marginal probability density function (PDF) with Gaussian belief propagation (BP), it is impor- tant to know whether it will converge in advance. By describing the message-passing process of Gaussian BP on the pairwise factor graph as a set of updating functions, the necessary and sufficient convergence condition of beliefs in synchronous Gaussian BP is first derived under a newly proposed initialization set. The pro- posed initialization set is proved to be largest among all currently known sets. Then, the necessary and sufficient convergence con- dition of beliefs in damped Gaussian BP is developed, with the allowable range of damping factor explicitly established. The re- sults theoretically confirm the extensively reported conjecture that damping is helpful to improve the convergence of Gaussian BP. Under totally asynchronous scheduling, a sufficient convergence condition of beliefs is also derived for the same proposed initializa- tion set. Relationships between the proposed convergence condi- tions and existing ones are established analytically. At last, numer- ical examples are presented to corroborate the established theories.published_or_final_versio

Determining the convergence of variance in Gaussian belief propagation via semi-definite programming

In order to compute the marginal distribution from a high dimensional distribution with loopy Gaussian belief propagation (BP), it is important to determine whether Gaussian BP would converge. In general, the convergence condition for Gaussian BP variance and mean are not necessarily the same, and this paper focuses on the convergence condition of Gaussian BP variance. In particular, by describing the message-passing process of Gaussian BP as a set of updating functions, the necessary and sufficient convergence condition of Gaussian BP variance is derived, with the converged variance proved to be independent of the initialization as long as it is greater or equal to zero. It is further proved that the convergence condition can be verified efficiently by solving a semi-definite programming (SDP) optimization problem. Numerical examples are presented to corroborate the established theories.published_or_final_versio

Terahertz sensor for non-contact thickness and quality measurement of automobile paints of varying complexity

In this paper, we propose to use terahertz pulsed imaging (TPI) as a novel tool to measure the thickness and quality of up to four layers of car paint on both metallic and non-metallic substrates. Using a rigorous one-dimensional electromagnetic model for terahertz propagation in a multi-layered medium combined with a numerical fitting method, the refractive index, extinction coefficient, and thickness of individual paint layers were determined. This proposed method was shown to be able to resolve coating layers down to a thickness of 18 $mu{hbox{m}}$ and was validated for both single- and multi-layer automobile paint samples. Results of the terahertz measurements were benchmarked against other techniques that are currently used for non-destructive testing during car manufacture: ultrasound and eddy current measurements, as well as two reference techniques, X-ray microcomputed tomography and surface profilometry. Good consistency was found between the techniques. Compared to conventional techniques, TPI has the advantage that it is a non-contact method and that it is able to spatially resolve the thickness uniformity distribution information by two-dimensional mapping.This work was supported in part by the Technology Strategy Boardunder Award 101262, and by the U.K. Engineering and Physical Sciences Research Council under EP/K503721/1.Full published version, which can also be found at: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=682722

Anti-inflammatory effects of naringin in chronic pulmonary neutrophilic inflammation in cigarette smoke-exposed rats

Naringin, a well-known flavanone glycoside of grapefruit and citrus fruits, was found to be as an effective anti-inflammatory compound in our previous lipopolysaccharide-induced acute lung injury mouse model via blockading activity of nuclear factor κB. The current study sought to explore the anti-inflammatory effects of naringin on chronic pulmonary neutrophilic inflammation in cigarette smoke (CS)-induced rats. Seventy Sprague-Dawley rats were randomly divided into seven groups to study the effects of CS with or without various concentrations of naringin or saline for 8 weeks. The results revealed that naringin supplementation at 20, 40, and 80mg/kg significantly increased body weight of CS-induced rats as compared to that in the CS group. Moreover, naringin of 20, 40, and 80mg/kg prevented CS-induced infiltration of neutrophils and activation of myeloperoxidase and matrix metalloproteinase-9, in parallel with suppression of the release of cytokines, such as tumor necrosis factor-α and interleukin-8 (IL-8). IL-10 in bronchoalveolar lavage fluid was significantly suppressed after CS exposure, but dose dependently elevated by naringin. The results from hematoxylin and eosin staining revealed that naringin dose dependently reduced CS-induced infiltration of inflammatory cells, thickening of the bronchial wall, and expansion of average alveolar airspace. In conclusion, our data suggest that naringin is an effective anti-inflammatory compound for attenuating chronic pulmonary neutrophilic inflammation in CS-induced rats. © Copyright 2012, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2012.published_or_final_versio

Janus monolayers of transition metal dichalcogenides.

Structural symmetry-breaking plays a crucial role in determining the electronic band structures of two-dimensional materials. Tremendous efforts have been devoted to breaking the in-plane symmetry of graphene with electric fields on AB-stacked bilayers or stacked van der Waals heterostructures. In contrast, transition metal dichalcogenide monolayers are semiconductors with intrinsic in-plane asymmetry, leading to direct electronic bandgaps, distinctive optical properties and great potential in optoelectronics. Apart from their in-plane inversion asymmetry, an additional degree of freedom allowing spin manipulation can be induced by breaking the out-of-plane mirror symmetry with external electric fields or, as theoretically proposed, with an asymmetric out-of-plane structural configuration. Here, we report a synthetic strategy to grow Janus monolayers of transition metal dichalcogenides breaking the out-of-plane structural symmetry. In particular, based on a MoS2 monolayer, we fully replace the top-layer S with Se atoms. We confirm the Janus structure of MoSSe directly by means of scanning transmission electron microscopy and energy-dependent X-ray photoelectron spectroscopy, and prove the existence of vertical dipoles by second harmonic generation and piezoresponse force microscopy measurements

Identification of Giardia lamblia DHHC Proteins and the Role of Protein S-palmitoylation in the Encystation Process

Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and provides a regulatory switch for protein membrane association. In this work, we analyzed the presence of DHHC proteins in the protozoa parasite Giardia lamblia and the function of the reversible S-palmitoylation of proteins during parasite differentiation into cyst. Two specific events were observed: encysting cells displayed a larger amount of palmitoylated proteins, and parasites treated with palmitoylation inhibitors produced a reduced number of mature cysts. With bioinformatics tools, we found nine DHHC proteins, potential protein acyltransferases, in the Giardia proteome. These proteins displayed a conserved structure when compared to different organisms and are distributed in different monophyletic clades. Although all Giardia DHHC proteins were found to be present in trophozoites and encysting cells, these proteins showed a different intracellular localization in trophozoites and seemed to be differently involved in the encystation process when they were overexpressed. dhhc transgenic parasites showed a different pattern of cyst wall protein expression and yielded different amounts of mature cysts when they were induced to encyst. Our findings disclosed some important issues regarding the role of DHHC proteins and palmitoylation during Giardia encystation.Fil: Merino, Maria Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Zamponi, Nahuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Vranych, Cecilia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Touz, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Ropolo, Andrea Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentin

The interface of syntax with pragmatics and prosody in children with Autism Spectrum Disorders

In order to study problems of individuals with Autism Spectrum Disorders (ASD) with morphosyntax, we investigated twenty high-functioning Greek-speaking children (mean age:6;11) and twenty age- and language-matched typically developing children on environments that allow or forbid object clitics or their corresponding noun phrase. Children with ASD fell behind typically developing in comprehending and producing simple clitics and producing noun phrases in focus structures. The two groups performed similarly in comprehending and producing clitics in clitic left dislocation and in producing noun phrases in non-focus structures. We argue that children with ASD have difficulties at the interface of(morpho)syntax with pragmatics and prosody, namely, distinguishing a discourse prominent element, and considering intonation relevant for a particular interpretation that excludes clitics

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers

Introduction Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by intersecting global gene transcription data from patients treated presurgically with the aromatase inhibitor anastrazole with those from MCF7 cells adapted to long-term oestrogen deprivation (LTED) (2) to assess the clinical value of selected genes in public clinical data sets and (3) to determine the impact of targeting these genes with novel agents. Methods Gene expression and Ki67 data were available from 69 postmenopausal women with oestrogen receptor–positive (ER+) early BC, at baseline and 2 weeks after anastrazole treatment, and from cell lines adapted to LTED. The functional consequences of target genes on proliferation, ER-mediated transcription and downstream cell signalling were assessed. Results By intersecting genes predictive of a poor change in Ki67 with those upregulated in LTED cells, we identified 32 genes strongly correlated with poor antiproliferative response that were associated with inflammation and/or immunity. In a panel of LTED cell lines, C-X-C chemokine receptor type 7 (CXCR7) and CXCR4 were upregulated compared to their wild types (wt), and CXCR7, but not CXCR4, was associated with reduced relapse-free survival in patients with ER+ BC. The CXCR4 small interfering RNA variant (siCXCR4) had no specific effect on the proliferation of wt-SUM44, wt-MCF7 and their LTED derivatives. In contrast, siCXCR7, as well as CCX733, a CXCR7 antagonist, specifically suppressed the proliferation of MCF7-LTED cells. siCXCR7 suppressed proteins associated with G1/S transition and inhibited ER transactivation in MCF7-LTED, but not wt-MCF7, by impeding association between ER and proline-, glutamic acid– and leucine-rich protein 1, an ER coactivator. Conclusions These data highlight CXCR7 as a potential therapeutic target warranting clinical investigation in endocrine-resistant BC