12 research outputs found
A Review on Structural Behavior, Design, and Application of Ultra-High-Performance Fiber-Reinforced Concrete
Get PDFEffective Synthesis of Silicon Carbide Nanotubes by Microwave Heating of Blended Silicon Dioxide and Multi-Walled Carbon Nanotube
Full text linkMolecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue—from (auto)antigen driven selection to the activation of NF-κB signaling
Full text linkThe application of steel-fibres as concrete reinforcement in Australia: from material to structure
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Shear Tests for Ultra-High Performance Fiber Reinforced Concrete (UHPFRC) Beams with Shear Reinforcement
No full textAn experimental investigation on the nano-fly ash preparation and its effects on the performance of self-compacting concrete at normal and elevated temperatures
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Mitofusin 2: from functions to disease
No full textAbstract Mitochondria are highly dynamic organelles whose functions are essential for cell viability. Within the cell, the mitochondrial network is continuously remodeled through the balance between fusion and fission events. Moreover, it dynamically contacts other organelles, particularly the endoplasmic reticulum, with which it enterprises an important functional relationship able to modulate several cellular pathways. Being mitochondria key bioenergetics organelles, they have to be transported to all the specific high-energy demanding sites within the cell and, when damaged, they have to be efficiently removed. Among other proteins, Mitofusin 2 represents a key player in all these mitochondrial activities (fusion, trafficking, turnover, contacts with other organelles), the balance of which results in the appropriate mitochondrial shape, function, and distribution within the cell. Here we review the structural and functional properties of Mitofusin 2, highlighting its crucial role in several cell pathways, as well as in the pathogenesis of neurodegenerative diseases, metabolic disorders, cardiomyopathies, and cancer
