A user-friendly wearable single-channel EOG-based human-computer interface for cursor control

This paper presents a novel wearable single-channel electrooculography (EOG) based human-computer interface (HCI) with a simple system design and robust performance. In the proposed system, EOG signals for control are generated from double eye blinks, collected by a commercial wearable device (the NeuroSky MindWave headset), and then converted into a sequence of commands that can control cursor navigations and actions. The EOG-based cursor control system was tested on 8 subjects in indoor or outdoor environment, and the average accuracy is 84.42% for indoor uses and 71.50% for outdoor uses. Compared with other existing EOG-based HCI systems, this system is highly user-friendly and does not require any training. Therefore, this system has the potential to provide an easy-to-use and cheap assistive technique for locked-in patients who have lost their main body muscular abilities but with proper eye-condition. © 2015 IEEE.published_or_final_versio

Efficient Implementation and Design of A New Single-Channel Electrooculography-based Human-Machine Interface System

published_or_final_versio

Complexity of Left-Ideal, Suffix-Closed and Suffix-Free Regular Languages

A language $L$ over an alphabet $\Sigma$ is suffix-convex if, for any words $x,y,z\in\Sigma^*$, whenever $z$ and $xyz$ are in $L$, then so is $yz$. Suffix-convex languages include three special cases: left-ideal, suffix-closed, and suffix-free languages. We examine complexity properties of these three special classes of suffix-convex regular languages. In particular, we study the quotient/state complexity of boolean operations, product (concatenation), star, and reversal on these languages, as well as the size of their syntactic semigroups, and the quotient complexity of their atoms.Comment: 20 pages, 11 figures, 1 table. arXiv admin note: text overlap with arXiv:1605.0669

Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study.

BackgroundExisting evidence suggests that proinflammatory cytokines play an intermediary role in postchemotherapy cognitive impairment. This is one of the largest multicentered, cohort studies conducted in Singapore to evaluate the prevalence and proinflammatory biomarkers associated with cognitive impairment in breast cancer patients.Patients and methodsChemotherapy-receiving breast cancer patients (stages I-III) were recruited. Proinflammatory plasma cytokines concentrations [interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor, interferon-γ and tumor necrosis factor-α] were evaluated at 3 time points (before chemotherapy, 6 and 12 weeks after chemotherapy initiation). The FACT-Cog (version 3) was utilized to evaluate patients' self-perceived cognitive disturbances and a computerized neuropsychological assessment (Headminder) was administered to evaluate patients' memory, attention, response speed and processing speed. Changes of cognition throughout chemotherapy treatment were compared against the baseline. Linear mixed-effects models were applied to test the relationships of clinical variables and cytokine concentrations on self-perceived cognitive disturbances and each objective cognitive domain.ResultsNinety-nine patients were included (age 50.5 ± 8.4 years; 81.8% Chinese; mean duration of education = 10.8 ± 3.3 years). Higher plasma IL-1β was associated with poorer response speed performance (estimate: -0.78; 95% confidence interval (CI) -1.34 to -0.03; P = 0.023), and a higher concentration of IL-4 was associated with better response speed performance (P = 0.022). Higher concentrations of IL-1β and IL-6 were associated with more severe self-perceived cognitive disturbances (P = 0.018 and 0.001, respectively). Patients with higher concentrations of IL-4 also reported less severe cognitive disturbances (P = 0.022).ConclusionsWhile elevated concentrations of IL-6 and IL-1β were observed in patients with poorer response speed performance and perceived cognitive disturbances, IL-4 may be protective against chemotherapy-associated cognitive impairment. This study is important because cytokines would potentially be mechanistic mediators of chemotherapy-associated cognitive changes

Partners in Social Entrepreneurship: A UK's Approach to Buyer's Risk Externalities

This article advances the idea that social entrepreneurship is achievable through partners working together within a supply chain. Following the 2008 economic crisis, three business trends have emerged in the UK-First, there is an increase in outsourcing activities. Second, recent UK laws have created an atypical workforce mostly composed of women. Third, there is an increase in social enterprises. This article highlights that the creation of buyer’s risk-externalities underpins these three trends’ modus operandi. Risk-externalities are the risks which businesses pass onto others in the attempt to reduce costs and burdens. Some businesses profit in this kind of environment. However, there are instances of adversities particular in the low-skilled labour sector where workers, especially women, are vulnerable to such externalities. These individuals are in the atypical workforce which is composed of zero-hours workers, fixed-term workers and agency workers. It is argued in this article that all atypical workers ought to have their interests protected because their struggles will ultimately become the community’s struggles. It is advanced here that the society’s fabric begins with the low-skilled workforce’s protection. Businesses ought to play a substantial role in maintaining society’s fabric through forming partners in social entrepreneurship

Assessing Levels of Attention Using Low Cost Eye Tracking

The emergence of mobile eye trackers embedded in next generation smartphones or VR displays will make it possible to trace not only what objects we look at but also the level of attention in a given situation. Exploring whether we can quantify the engagement of a user interacting with a laptop, we apply mobile eye tracking in an in-depth study over 2 weeks with nearly 10.000 observations to assess pupil size changes, related to attentional aspects of alertness, orientation and conflict resolution. Visually presenting conflicting cues and targets we hypothesize that it's feasible to measure the allocated effort when responding to confusing stimuli. Although such experiments are normally carried out in a lab, we are able to differentiate between sustained alertness and complex decision making even with low cost eye tracking "in the wild". From a quantified self perspective of individual behavioral adaptation, the correlations between the pupil size and the task dependent reaction time and error rates may longer term provide a foundation for modifying smartphone content and interaction to the users perceived level of attention.Comment: 12 pages, 6 figures, 2 tables. The final publication will be available at Springer via http://dx.doi.org/DOIxxx, when published as part of the HCI International 2016 Conference Proceeding

A cost-effectiveness analysis evaluating endoscopic surveillance for gastric cancer for populations with low to intermediate risk

10.1371/journal.pone.0083959PLoS ONE812-POLN

Mechanisms and models of somatic cell reprogramming

Whitehead Institute for Biomedical Research (Jerome and Florence Brill Graduate Student Fellowship)National Institutes of Health (U.S.) (US NIH grant RO1-CA087869)National Institutes of Health (U.S.) (US NIH grant R37-CA084198)National Science Foundation (U.S.) (NSF Graduate Research Fellowship)National Institutes of Health (U.S.) ((NIH) Kirschstein National Research Service Award,1 F32 GM099153-01A1)Vertex Pharmaceuticals Incorporated (Vertex Scholar

Recovery of Lactobacillus casei strain Shirota (LcS) from faeces of healthy Singapore adults after intake of fermented milk

To validate survival of Lactobacillus casei strain Shirota (LcS) during passage through the gastrointestinal tract of healthy Singaporean young adults, 21 participants (18-25 years old) were asked to consume a 100 ml of fermented milk drink containing 1.0x10(8) cfu/ml of LcS daily for 14 days, and to maintain their dietary habit and life style. During and at the end of the ingestion period, both culture method (identity confirmed by ELISA) and 16s rRNA sequencing results revealed that viable LcS (7.27 and 7.64 log(10) cfu/g of faeces at the ingestion period Day 7 and Day 14, respectively) and Lactobacillus could be recovered from the faeces of all the subjects. The viable LcS count from male and female were comparable for each time point. Before consumption (baseline) and 14 days after cessation of consumption of the fermented milk, LcS was not detected in most of the subjects. In this study condition, the composition of the major gut microbiota (>0.1% in relative abundance of genus) and characteristics of defaecation such as stool consistency and frequency of defecation did not change throughout the study before and after ingestion of LcS. LcS was able to survive passage through the gastrointestinal tract of Singapore adults without sustainable colonisation, but the effect of LcS on microbiota modulation, stool consistency and frequency was not observed under this study condition