688 research outputs found
Graphene plasmonics
Two rich and vibrant fields of investigation, graphene physics and
plasmonics, strongly overlap. Not only does graphene possess intrinsic plasmons
that are tunable and adjustable, but a combination of graphene with noble-metal
nanostructures promises a variety of exciting applications for conventional
plasmonics. The versatility of graphene means that graphene-based plasmonics
may enable the manufacture of novel optical devices working in different
frequency ranges, from terahertz to the visible, with extremely high speed, low
driving voltage, low power consumption and compact sizes. Here we review the
field emerging at the intersection of graphene physics and plasmonics.Comment: Review article; 12 pages, 6 figures, 99 references (final version
available only at publisher's web site
Multilevel Deconstruction of the In Vivo Behavior of Looped DNA-Protein Complexes
Protein-DNA complexes with loops play a fundamental role in a wide variety of
cellular processes, ranging from the regulation of DNA transcription to
telomere maintenance. As ubiquitous as they are, their precise in vivo
properties and their integration into the cellular function still remain
largely unexplored. Here, we present a multilevel approach that efficiently
connects in both directions molecular properties with cell physiology and use
it to characterize the molecular properties of the looped DNA-lac repressor
complex while functioning in vivo. The properties we uncover include the
presence of two representative conformations of the complex, the stabilization
of one conformation by DNA architectural proteins, and precise values of the
underlying twisting elastic constants and bending free energies. Incorporation
of all this molecular information into gene-regulation models reveals an
unprecedented versatility of looped DNA-protein complexes at shaping the
properties of gene expression.Comment: Open Access article available at
http://www.plosone.org/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1371%2Fjournal.pone.000035
The intersection form of production possibility set in DEA and its applications
2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe
Automated tongue segmentation in hyperspectral images for medicine
Author name used in this publication: Jing-qi YanAuthor name used in this publication: David ZhangVersion of RecordPublishe
Higher-order multipole amplitude measurement in ψ ′→γχ c2
Using 106×106 ψ ′ events collected with the BESIII detector at the BEPCII storage ring, the higher-order multipole amplitudes in the radiative transition ψ ′→γχ c2→γπ +π -/γK +K - are measured. A fit to the χ c2 production and decay angular distributions yields M2=0.046±0. 010±0.013 and E3=0.015±0.008±0.018, where the first errors are statistical and the second systematic. Here M2 denotes the normalized magnetic quadrupole amplitude and E3 the normalized electric octupole amplitude. This measurement shows evidence for the existence of the M2 signal with 4.4σ statistical significance and is consistent with the charm quark having no anomalous magnetic moment. © 2011 American Physical Society.published_or_final_versio
Two-photon widths of the χ c0,2 states and helicity analysis for χ c2→γγ
Based on a data sample of 106×106 ψ ′ events collected with the BESIII detector, the decays ψ ′→γχ c0,2, χ c0,2→γγ are studied to determine the two-photon widths of the χ c0,2 states. The two-photon decay branching fractions are determined to be B(χ c0→γγ)=(2. 24±0.19±0.12±0.08)×10 -4 and B(χ c2→γγ)=(3.21±0.18±0. 17±0.13)×10 -4. From these, the two-photon widths are determined to be Γ γγ(χ c0)=(2. 33±0.20±0.13±0.17)keV, Γ γγ(χ c2)=(0.63±0.04±0. 04±0.04)keV, and R=Γ γγ(χ c2)/ Γ γγ(χ c0)=0.271±0. 029±0.013±0.027, where the uncertainties are statistical, systematic, and those from the PDG B(ψ ′→γχ c0,2) and Γ(χ c0,2) errors, respectively. The ratio of the two-photon widths for helicity λ=0 and helicity λ=2 components in the decay χ c2→γγ is measured for the first time to be f 0/2=Γγγλ= 0(χ c2)/Γγγλ=2(χ c2)=0. 00±0.02±0.02. © 2012 American Physical Society.published_or_final_versio
Home-Based Self-Management After Permanent Pacemaker Implantation: What Should Patients Know
Han Yan,1,* Yu Shuang Chen,2,* Yi Li,2 Guan-Xing Wei,2 Fang Ma,3 Qiu Lan Hu,4 Lan Ding,5 Wei Wei,6 Yan Li,7 Yang-Juan Bai2 1Intensive Care Unit of Cardiac Surgery Department, QingDao Municipal Hospital (Group), Qingdao, Shandong, People’s Republic of China; 2The First Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 3Nursing Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 4Geriatric Intensive Care Unit, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 5Outpatient Department, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 6Department of Gastrointestinal Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 7Department of Obstetrics, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang-Juan Bai, The First Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, No. 295, Xichang Road, Kunming, Yunnan, 650032, People’s Republic of China, Tel +8613678757051, Email [email protected]: The purpose of this study is to systematically explore and summarize the best evidence of home-based self-management in patients with permanent pacemaker implantation, providing comprehensive references and guidance for improving the self-management ability of such patients.Methods: Using the “ 6S” model, a systematic literature search was conducted on home-based self-management in patients with permanent pacemaker implantation. The types of literature included best practice, clinical decision-making, guidelines, expert consensus, systematic review and evidence summary. According to the inclusion and exclusion criteria, two researchers screened the literature, evaluated the quality, extracted the data, synthesized the evidence.Data Sources: BMJ Best Practice, Up To Date, Joanna Briggs Institute (JBI), the World Health Organization (WHO), the Guidelines International Network (GIN), the National Institute for Health and Care Excellence (NICE), the Registered Nurses Association of Ontario (RNAO), the Scottish Intercollegiate Guidelines Network (SIGN), the American Heart Association (AHA), the Cochrane Library, PubMed, CINAHL, Web of Science, Medlive, CNKI Database, SinoMed (China Biomedical Literature Database), Wanfang Database and VIP Database. The retrieval period spanned from the establishment of these databases until January 31, 2025.Results: A total of 21 articles were included, 1 best practice, 9 clinical decision-making, 5 guidelines, 3 expert consensus, 1 systematic review, and 2 evidence summaries. Thirty-five pieces of the best evidence from 7 aspects were summarized, including complication management, electromagnetic interference management, sports rehabilitation management, operative limb management, postoperative follow-up management, role management, and emotional management.Conclusion: This review comprehensively summarized the best evidence home-based self-management in patients with permanent pacemaker implantation. These findings are scientific and referential, and provide evidence-based support for nursing and management of patients during home-based rehabilitation.Keywords: permanent pacemaker, self-management, best evidence, evidence-based nursin
XIAP impairs Smac release from the mitochondria during apoptosis
X-linked inhibitor of apoptosis protein (XIAP) is a potent inhibitor of caspases 3, 7 and 9, and mitochondrial Smac (second mitochondria-derived activator of caspase) release during apoptosis inhibits the activity of XIAP. In this study we show that cytosolic XIAP also feeds back to mitochondria to impair Smac release. We constructed a fluorescent XIAP-fusion protein by labelling NH2- and COOH-termini with Cerulean fluorescent protein (C-XIAP-C). Immunoprecipitation confirmed that C-XIAP-C retained the ability to interact with Smac and impaired extrinsically and intrinsically activated apoptosis in response to tumour necrosis factor-related apoptosis-inducing ligand/cycloheximide and staurosporine. In C-XIAP-C-expressing cells, cytochrome c release from mitochondria proceeded normally, whereas Smac release was significantly prolonged and incomplete. In addition, physiological expression of native XIAP prolonged or limited Smac release in HCT-116 colon cancer cells and primary mouse cortical neurons. The Smac-binding capacity of XIAP, but not caspase inhibition, was central for mitochondrial Smac retention, as evidenced in experiments using XIAP mutants that cannot bind to Smac or effector caspases. Similarly, the release of a Smac mutant that cannot bind to XIAP was not impaired by C-XIAP-C expression. Full Smac release could however be provoked by rapid cytosolic C-XIAP-C depletion upon digitonin-induced plasma membrane permeabilization. Our findings suggest that although mitochondria may already contain pores sufficient for cytochrome c release, elevated amounts of XIAP can selectively impair and limit the release of Smac
Seed Regeneration Potential of Canopy Gaps at Early Formation Stage in Temperate Secondary Forests, Northeast China
Promoting the seed regeneration potential of secondary forests undergoing gap disturbances is an important approach for achieving forest restoration and sustainable management. Seedling recruitment from seed banks strongly determines the seed regeneration potential, but the process is poorly understood in the gaps of secondary forests. The objectives of the present study were to evaluate the effects of gap size, seed availability, and environmental conditions on the seed regeneration potential in temperate secondary forests. It was found that gap formation could favor the invasion of more varieties of species in seed banks, but it also could speed up the turnover rate of seed banks leading to lower seed densities. Seeds of the dominant species, Fraxinus rhynchophylla, were transient in soil and there was a minor and discontinuous contribution of the seed bank to its seedling emergence. For Quercus mongolica, emerging seedling number was positively correlated with seed density in gaps (R = 0.32, P<0.01), especially in medium and small gaps (<500 m2). Furthermore, under canopies, there was a positive correlation between seedling number and seed density of Acer mono (R = 0.43, P<0.01). Gap formation could promote seedling emergence of two gap-dependent species (i.e., Q. mongolica and A. mono), but the contribution of seed banks to seedlings was below 10% after gap creation. Soil moisture and temperature were the restrictive factors controlling the seedling emergence from seeds in gaps and under canopies, respectively. Thus, the regeneration potential from seed banks is limited after gap formation
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