Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.

The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators. Quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) data indicated that ectopic expression of orphan nuclear receptor Nur77 markedly increased the expression of latexin-3 (RLN3), but not relaxin-1 (RLN1), in neonatal rat ventricular cardiomyocytes (NRVMs). Furthermore, we found that the -adrenergic agonist isoproterenol (ISO) markedly stimulated RLN3 expression, and this stimulation was significantly attenuated in Nur77 knockdown cardiomyocytes and Nur77 knockout hearts. We showed that Nur77 significantly increased RLN3 promoter activity via specific binding to the RLN3 promoter, as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immuno-precipitation (ChIP) assays. Furthermore, we found that Nur77 overexpression potently inhibited ISO-induced cardiomyocyte apoptosis, whereas this protective effect was significantly attenuated in RLN3 knockdown cardiomyocytes, suggesting that Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis. These findings show that Nur77 regulates RLN3 expression, therefore suppressing apoptosis in the heart, and suggest that activation of Nur77 may represent a useful therapeutic strategy for inhibition of cardiac fibrosis and heart failure. © 2018 You et al

Source attack of decoy-state quantum key distribution using phase information

Quantum key distribution (QKD) utilizes the laws of quantum mechanics to achieve information-theoretically secure key generation. This field is now approaching the stage of commercialization, but many practical QKD systems still suffer from security loopholes due to imperfect devices. In fact, practical attacks have successfully been demonstrated. Fortunately, most of them only exploit detection-side loopholes which are now closed by the recent idea of measurement-device-independent QKD. On the other hand, little attention is paid to the source which may still leave QKD systems insecure. In this work, we propose and demonstrate an attack that exploits a source-side loophole existing in qubit-based QKD systems using a weak coherent state source and decoy states. Specifically, by implementing a linear-optics unambiguous-state-discrimination measurement, we show that the security of a system without phase randomization --- which is a step assumed in conventional security analyses but sometimes neglected in practice --- can be compromised. We conclude that implementing phase randomization is essential to the security of decoy-state QKD systems under current security analyses.Comment: 12 pages, 5 figure

Electronic structure of heavy fermion system CePt2In7 from angle-resolved photoemission spectroscopy

We have carried out high-resolution angle-resolved photoemission measurements on the Cebased heavy fermion compound CePt2In7 that exhibits stronger two-dimensional character than the prototypical heavy fermion system CeCoIn5. Multiple Fermi surface sheets and a complex band structure are clearly resolved. We have also performed detailed band structure calculations on CePt2In7. The good agreement found between our measurements and the calculations suggests that the band renormalization effect is rather weak in CePt2In7. A comparison of the common features of the electronic structure of CePt2In7 and CeCoIn5 indicates that CeCoIn5 shows a much stronger band renormalization effect than CePt2In7. These results provide new information for understanding the heavy fermion behaviors and unconventional superconductivity in Ce-based heavy fermion systems.Comment: 24 pages, 10 figure

Entanglement dynamics of two-qubit system in different types of noisy channels

In this paper, we study entanglement dynamics of a two-qubit extended Werner-like state locally interacting with independent noisy channels, i.e., amplitude damping, phase damping and depolarizing channels. We show that the purity of initial entangled state has direct impacts on the entanglement robustness in each noisy channel. That is, if the initial entangled state is prepared in mixed instead of pure form, the state may exhibit entanglement sudden death (ESD) and/or be decreased for the critical probability at which the entanglement disappear.Comment: 11 pages, 6 figure

e+e−→Λc+Λˉc−e^+ e^- \to \Lambda^+_c \bar{\Lambda}^-_c cross sections and the Λc+\Lambda_c^+ electromagnetic form factors within the extended vector meson dominance model

Within the extended vector meson dominance model, we investigate the $e^+ e^- \to \Lambda^+_c \bar{\Lambda}^-_c$ reaction and the electromagnetic form factors of the charmed baryon $\Lambda_c^+$. The model parameters are determined by fitting them to the cross sections of the process $e^+e^-\rightarrow \Lambda_c^+ \bar{\Lambda}_c^-$ and the magnetic form factor $|G_M|$ of $\Lambda^+_c$. By considering four charmoniumlike states, called $\psi(4500)$, $\psi(4660)$, $\psi(4790)$, and $\psi(4900)$, we can well describe the current data on the $e^+ e^- \to \Lambda^+_c \bar{\Lambda}^-_c$ reaction from the reaction threshold up to $4.96 \ \mathrm{GeV}$. In addition to the total cross sections and $|G_M|$, the ratio $|G_E/G_M|$ and effective form factor $|G_{\mathrm{eff}}|$ for $\Lambda^+_c$ are also calculated, and found that these calculations are consistent with the experimental data. Within the fitted model parameters, we have also estimated the charge radius of the charmed $\Lambda_c^+$ baryon.Comment: 7 pages, 6 figures. Published versio

Reweighting Signal Spectra to Improve Spatial Sensitivity for an Electrostatic Sensor

The ring-shaped electrostatic sensor is a gas–solid flow measurement system, which has a problem of flow profile dependency. To deal with this problem, a method was introduced in this paper, which was to repeatedly use the successive “tails” of the sensor’s overall output power spectrum to identify elementary frequency components corresponding to the equivalent roping flow streams. From the radial locations of these equivalent flow streams, the decomposed power frequency spectral components were then reweighted accordingly. Through such signal processing, an improved electrostatic sensor spatial sensitivity was achieved without modifying the sensor’s structure. The method of interpolation was presented and discussed, and the effect of velocity profile on the proposed method was evaluated under different velocity profiles