Competition in Hong Kong’s banking industry

This paper tests the competition structure of Hong Kong’s banking industry using the Panzar-Rosse approach and a panel dataset of the largest 20 banks in Hong Kong from 1998 to 2011. The estimation results showed that the competitive pressures were equal across time and across the different sizes of the banks in Hong Kong’s banking industry. Competitive pressures may heighten in the near future as banks will seek to gain competitive edge and they can do so through mergers and acquisitions. Regulations are also slowly being relaxed after the financial crisis in order to boost the economy and more advances in technology are also anticipated

The LAMOST Survey of Background Quasars in the Vicinity of the Andromeda and Triangulum Galaxies -- II. Results from the Commissioning Observations and the Pilot Surveys

We present new quasars discovered in the vicinity of the Andromeda and Triangulum galaxies with the LAMOST during the 2010 and 2011 observational seasons. Quasar candidates are selected based on the available SDSS, KPNO 4 m telescope, XSTPS optical, and WISE near infrared photometric data. We present 509 new quasars discovered in a stripe of ~135 sq. deg from M31 to M33 along the Giant Stellar Stream in the 2011 pilot survey datasets, and also 17 new quasars discovered in an area of ~100 sq. deg that covers the central region and the southeastern halo of M31 in the 2010 commissioning datasets. These 526 new quasars have i magnitudes ranging from 15.5 to 20.0, redshifts from 0.1 to 3.2. They represent a significant increase of the number of identified quasars in the vicinity of M31 and M33. There are now 26, 62 and 139 known quasars in this region of the sky with i magnitudes brighter than 17.0, 17.5 and 18.0 respectively, of which 5, 20 and 75 are newly-discovered. These bright quasars provide an invaluable collection with which to probe the kinematics and chemistry of the ISM/IGM in the Local Group of galaxies. A total of 93 quasars are now known with locations within 2.5 deg of M31, of which 73 are newly discovered. Tens of quasars are now known to be located behind the Giant Stellar Stream, and hundreds behind the extended halo and its associated substructures of M31. The much enlarged sample of known quasars in the vicinity of M31 and M33 can potentially be utilized to construct a perfect astrometric reference frame to measure the minute PMs of M31 and M33, along with the PMs of substructures associated with the Local Group of galaxies. Those PMs are some of the most fundamental properties of the Local Group.Comment: 26 pages, 6 figures, AJ accepte

Involvement of ubiquitination in Alzheimer’s disease

The hallmark pathological features of Alzheimer’s disease (AD) consist of senile plaques, which are formed by extracellular β-amyloid (Aβ) deposition, and neurofibrillary tangles, which are formed by the hyperphosphorylation of intra-neuronal tau proteins. With the increase in clinical studies, the in vivo imbalance of iron homeostasis and the dysfunction of synaptic plasticity have been confirmed to be involved in AD pathogenesis. All of these mechanisms are constituted by the abnormal accumulation of misfolded or conformationally altered protein aggregates, which in turn drive AD progression. Proteostatic imbalance has emerged as a key mechanism in the pathogenesis of AD. Ubiquitination modification is a major pathway for maintaining protein homeostasis, and protein degradation is primarily carried out by the ubiquitin-proteasome system (UPS). In this review, we provide an overview of the ubiquitination modification processes and related protein ubiquitination degradation pathways in AD, focusing on the microtubule-associated protein Tau, amyloid precursor protein (APP), divalent metal transporter protein 1 (DMT1), and α-amino-3-hyroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. We also discuss recent advances in ubiquitination-based targeted therapy for AD, with the aim of contributing new ideas to the development of novel therapeutic interventions for AD

Correlation of RELL1 Expression with Clinical Pathological Characteristics and Prognosis of Patients with Colon Cancer

ObjectiveTo explore the correlation of RELL1 expression with clinical pathological features and prognosis of patients with colon cancer. MethodsImmunohistochemical experiments of the RELL1 protein were performed on tissue chips from 80 colon cancer tissues and 80 adjacent tissues. The relationship between different expression levels of RELL1 protein and clinical pathological parameters was compared. Univariate and multivariate Cox risk proportional regression analyses were conducted on factors affecting the survival of patients with colon cancer. Kaplan-Meier survival curve analysis was conducted on the survival rates of patients with colon cancer and different levels of RELL1 expression. Log rank test was performed to evaluate differences in survival rates. ResultsThe expression of RELL1 in colon cancer tissues was lower than that in adjacent tissues (P<0.05). The expression of RELL1 in cancer tissues is correlated with TNM stage and N stage (P<0.05). The 3-year overall survival (OS) rate of colon cancer patients with high RELL1 expression was higher than that of patients with low RELL1 expression (P<0.05). Multivariate Cox regression analysis showed that low RELL1 expression, advanced age, and high TNM stage were risk factors for poor prognosis in patients with colon cancer (P<0.05). ConclusionThe expression of RELL1 is downregulated in colon cancer tissue, and the low RELL1 expression, advanced age, and high TNM stage can lead to adverse outcomes in patients

Development of an Aerodynamic Lens-Proton Transfer Reaction Mass Spectrometry (PTR-MS) Apparatus for Online Detection of Organic Compounds in Aerosol Particles

Atmospheric organic aerosols consist of both gas-phase organic compounds and particle-phase organic compounds. The components of aerosol particles (solid or liquid droplets) can undergo exchange or chemical reactions with gas-phase components, influencing atmospheric physical and chemical processes and potentially impacting atmospheric environment, climate, and human health. Methods for detecting organic compounds in aerosol particle phase are classified into offline and online detection. Offline detection methods involve collecting aerosol samples for analysis using chromatography-mass spectrometry, which is time-consuming and limited sensitivity. Online detection methods involve enriching aerosols through aerodynamic lens and then detecting them using laser ablation or electron impact ionization techniques. However, these methods usually generate a large number of ion fragments, making mass spectrum analysis difficult. Therefore, it is necessary to develop an online detection method for aerosol particle-phase organic compounds with soft ionization and high sampling efficiency. In the present work, a set of aerodynamic lens sampling systems was designed and developed for online detection and analysis of organic compounds in aerosol particle phase. This sampling system consists of a gas-phase stripping module for removing gas-phase organic compounds, an aerodynamic lens module for particle focusing and enrichment, and a thermal desorption module for extracting particle-phase organic compounds. The efficiency of gas-phase organic compound removal and the particle transmission rate of the gas-phase stripping module were firstly investigated. The results showed that gas-phase stripping module achieves a removal efficiency of 98.89% for gas-phase organic compounds, and the particle transmission rate ranges from 75.16% to 91.15% for particles with the diameters between 295 and 375 nm. Subsequently, the effectiveness of the aerodynamic lens was studied through theoretical simulations. The simulation results indicated that the transmission rate of particles in the diameters of 0.36-6.0 μm is above 90% in the designed aerodynamic lens. Finally, The designed aerodynamic lens sampling system with a homemade proton transfer reaction mass spectrometer (PTR-MS) was integrated to develop an aerodynamic lens-PTR-MS device. This device was tested by detecting simulated aerosol samples containing reaction products of α-pinene and ozone. The mass spectrometry results demonstrated that the intensity changes of the examined ten ions are closely related to the presence of α-pinene, confirming that the device can achieve online detection of organic compounds in aerosols ranging from submicron to several micrometers

Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants

Vitiligo is an autoimmune disease in which depigmented skin results from the destruction of melanocytes1, with epidemiological association with other autoimmune diseases2. In previous linkage and genome-wide association studies (GWAS1 and GWAS2), we identified 27 vitiligo susceptibility loci in patients of European ancestry. We carried out a third GWAS (GWAS3) in European-ancestry subjects, with augmented GWAS1 and GWAS2 controls, genome-wide imputation, and meta-analysis of all three GWAS, followed by an independent replication. The combined analyses, with 4,680 cases and 39,586 controls, identified 23 new significantly associated loci and 7 suggestive loci. Most encode immune and apoptotic regulators, with some also associated with other autoimmune diseases, as well as several melanocyte regulators. Bioinformatic analyses indicate a predominance of causal regulatory variation, some of which corresponds to expression quantitative trait loci (eQTLs) at these loci. Together, the identified genes provide a framework for the genetic architecture and pathobiology of vitiligo, highlight relationships with other autoimmune diseases and melanoma, and offer potential targets for treatment

Dual-drift Tube Ion Mobility Spectrometry Based on Corona Discharge Ionization Source

Ion mobility spectrometry (IMS) is a trace detection technique operating at atmospheric pressure. It is widely utilized in various fields, such as explosives and drug detection, chemical warfare agent detection, and biomedical applications, due to its fast response time and high sensitivity. The various of substances can be identified through analyzing the discrepancies in the drift time of charged particles in an electric field. Depending on the polarity of the charged particles, it can operate under either positive or negative ion mode. Currently, the majority of IMS operate in only one detection mode. For example, explosives detection operates under negative ion mode, while drug detection operates under positive ion mode. However, single detection mode system is prone to miss detections because some substances may differentially respond to positive and negative detection modes. Simultaneous detection under both positive and negative ion modes can further enhance detection accuracy. In this study, a dual-drift tube ion mobility spectrometry capable of simultaneously detecting positive and negative ions was constructed using corona discharge ionization source technology and a compact dual ion-gated pulse control circuit. The instrument parameters of IMS were optimized, while simultaneously determined hexogen, methamphetamine and the metabolite of trinitrotoluene (TNT)，2,4-diamino-6-nitrotoluene (2,4-DANT). The optimal experimental conditions were selected as follows: a drift gas flow rate of 600 mL/min, a carrier gas flow rate of 500 mL/min, a drift tube temperature of 100 ℃, and a thermal desorption temperature of 200 ℃. The reduced mobility values of 1.72 cm2/V·s and 1.44 cm2/V·s are obtained through the detection of explosive hexogen (RDX) and drug methamphetamine (MA), respectively. These values agree well with the reported values, thereby proving the reliability of the instrument’s detection. Finally, the performance of the developed instrument was evaluated using 2,4-DANT, this substance that can be detected under both positive and negative ion modes. Production peaks are observed in both modes, and the normalized mobility values for 2,4-DANT are reported as approximately 1.67 cm2/V·s and 1.33 cm2/V·s under positive and negative ion modes, respectively. Through exploring the detection limits for both positive and negative ions, it was revealed that the homemade dual ion mobility spectrometer is capable of simultaneous detection of both positive and negative ions, achieves the lowest detection limits of 200 pg and 260 pg for 2,4-DANT, respectively. Importantly, these detection limits are not significantly compromised by sample division, which underscores the broad applicability and value of the instrument, highlighting its potential in various fields

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Insights into salt tolerance from the genome of Thellungiella salsuginea

Thellungiella salsuginea, a close relative of Arabidopsis, represents an extremophile model for abiotic stress tolerance studies. We present the draft sequence of the T. salsuginea genome, assembled based on ∼134-fold coverage to seven chromosomes with a coding capacity of at least 28,457 genes. This genome provides resources and evidence about the nature of defense mechanisms constituting the genetic basis underlying plant abiotic stress tolerance. Comparative genomics and experimental analyses identified genes related to cation transport, abscisic acid signaling, and wax production prominent in T. salsuginea as possible contributors to its success in stressful environments

National Brain Tumour Registry of China (NBTRC) statistical report of primary brain tumours diagnosed in China in years 2019-2020

BACKGROUND: The lack of a well-designed brain tumour registry with standardized pathological diagnoses in underdeveloped countries hinders the ability to compare epidemiologic data across the globe. The National Brain Tumour Registry of China (NBTRC), created in January 2018, is the first multi-hospital-based brain tumour registry in China. Patient data reported to the NBTRC in years 2019-2020 were assessed. METHODS: Tumour pathology was based on the 2016 World Health Organization (WHO) classification of tumours of the central nervous system and ICD-O-3. The anatomical site was coded per the Surveillance, Epidemiology, and End Results (SEER) solid tumour module (version of July 2019). The cases were tabulated by histology and anatomical site. Categorical variables were reported as numbers (percentages). The distribution of tumours by age (0-14, 15-19, 20-39, 40-64, and 65+ years) was analysed. FINDINGS: There were a total of 25,537 brain tumours, foremost among them meningioma (23.63%), followed by tumours of the pituitary (23.42%), and nerve sheath tumours (9.09%). Glioblastoma, the most common and lethal form of primary brain cancer in adults, represented 8.56% of all cases. Of note, 6.48% of the malignant tumours were located in the brain stem. The percentage of malignant brain tumours decreased with increasing age, 24.08% in adults (40+ years), 30.25% in young adults (20-39 years), 35.27% in adolescents (15-19 years), and 49.83% in children (0-14 years). Among the 2107 paediatric patients, the most common sites were ventricle (17.19%), brainstem (14.03%), pituitary and craniopharyngeal duct (13.4%), and cerebellum (12.3%), a distribution that differed from that of the entire cohort. The histology distribution was also unique in children, with glioblastoma much less incident compared to the whole cohort (3% vs. 8.47%, INTERPRETATION: The histological and anatomical site distribution of brain tumours in the NBTRC was statistically different in the subgroup of children (0-14 years). Patient choice of pursuing trans-provincial treatment was common and the in-hospital LOS was longer compared to that reported in similar European and American patient populations, which merits further attention. FUNDING: The National Key Research and Development Program of China (2015BAI12B04, 2013BAI09B03, 2014BAI04B01, and 2021YFF1201104) and Chinese National Natural Science Foundation of China (81971668)