My Amma, Bhopal

Creative writin

Preserving modern architecture & new railway infrastructure in New Delhi

New Delhi/ Naiee Dilli is one of the cities in the world which has been destroyed and rebuilt 10 times since 3100BC. Starting with the name of Indraprastha and ending with Lutyens’s Delhi in 1911AD. Currently, Delhi still shows the footprints of all the 10 destroyed cities. The major change happened during the Lutyens’s planning and after the post-independence where India started getting engaged with the new construction technology with industrial materials which were introduced by the colonizers. The architecture of post-colonial Delhi was to change the image of a growing city to a developed city. An era where Indian cities were getting ready for globalization and welcoming outsiders to invest. The structure of these buildings where getting defined as experiments with the new shapes and techniques for future generation architects to inspire and continue the same with the concept of brutalism and old heritage buildings in India. This also started shaping the land usage and other neighboring buildings in society with relation to colonial radial city planning keeping heritage and modernism in the same bracket. Most of the building programs were the government’s office, market spaces, exhibition spaces, hotels, and low-cost housing for the lower middle class of Delhi. But in 21st century India people and government have started forgetting about the importance of these buildings leading to demolition. One of the examples can be New Delhi Railway Station building also known as NDLS or Paharganj side railway station building. The government is again demolishing this structure and pursuing a structure that is out of the context of New Delhi’s architecture. Also, Railway stations in India are one of the oldest buildings across the nation which keeps getting retrofitted with new elements of today’s building to look aesthetically up to date but, from inside the structure, space remains the same as it was during the British era. Across India old railway stations have been following the infrastructure as defined by the Britishers when they started developing railways during their rule across the country (India, Pakistan, and Bangladesh). In particular, the New Delhi railway station has been a critical point for India’s redevelopment of Indian Railways. It is the second busiest station in India and lies in the capital of India. My research aim can be framed under the light of studying these structures with their contrasting construction techniques and to know how railway stations can be improved by giving a new civic culture space including amenities and regulations. Reflecting the culture of the region while being an important civic node for efficient transportation of people and cargo around New Delhi and the rest of the country

The Chief Executive Officer and the Chief Information Officer: The Strategic Partnership

Information technology (IT) has become a strategic resource for many firms today. Coordination of this resource requires strong leadership and cooperation within the firm. The relationship of the Chief Executive Officer (CEO) and the Chief Information Officer (CIO) is crucial for the effective, successful utilization of IT for competitive advantage. This paper first explores the CIO position, giving reasons for its development, tracing its evolution, and pinpointing certain responsibilities associated with the position. The paper then highlights the CIO\u27s concerns and identifies the future implications for the CIO. The second portion of the paper takes the CEO\u27s perspective towards IT and the CIO\u27s position. Special attention is directed towards describing the CEO\u27s perspective on the CIO\u27s qualifications, addressing the problem of overblown CEO expectations for the CIO position, and discussing ‘old-line’ CEOs’ attitudes towards IT and the CIO position. Also addressed is the exploration of the common CEO perception of the CIO as an ‘empire builder’ and an analysis of the CEO\u27s perspective on the future need for a CIO position. Finally the paper focuses on developing this ‘strategic partnership’ between the CIO and the CEO. Suggestions are provided for the CIO and the CEO to help achieve this ideal partnership. Although these suggestions are not all conclusive, they are critical to the ‘partnership’

BACTERICIDAL ACTIVITY OF DIFFERENT PARTS OF AZADIRACHTA INDICA ON PROBIOTIC MICROBES

ABSTRACTObjective: The purpose of the present study was to investigate the bactericidal activity of different parts of Azadirachta indica plant against probioticmicrobes such as Bacillus clausii, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei and Saccharomyces boulardii that were foundto be present in these commercial available probiotic products such as yoghurt, probase, enterogermina and various other types of fermented food. Methods: Bactericidal activity of different parts of Azadirachta indica plant considering leaves, barks and seeds were observed by agar well diffusionmethod by calculating inhibition length. Phytochemical screening was done in aqueous and methanolic extracts of leaves, barks and seed of Azadirachtaindica plant in order to reveal the presence of secondary metabolite in the defined extracts.Results: The present study has revealed the presence of maximum bactericidal activity in its aqueous extracts of leaves as compared to the bark and seed.Conclusion: This can be concluded from the present study to recommend to utilize the bark and seed as traditional herbal remedies that has shownless amount of bactericidal activity against the probiotic microbes.Keywords: Probiotic microbes, Phytochemical screening, Bactericidal activity, Agar well-diffusion method, Azadirachta indica

Characterizing the Potential of a Ferric Siderophore Receptor as a Putative B. pertussis Vaccine Antigen

Pertussis (whooping cough), the disease caused by the bacterium Bordetella pertussis, has been resurging despite widespread vaccination, and this is mainly attributed to the switch to acellular pertussis vaccines (aPV) from whole cell pertussis vaccines (wPV). This correlation, as well as the emergence of strains lacking antigens in the current aPV formulations, suggests that novel Bp antigens should be explored to engineer a next-generation aPV. Looking at another aspect of B. pertussis pathogenesis that is not addressed by the current aPV formulations, siderophores are necessary for survival and proliferation to scavenge ferric iron cations (Fe3+) in the iron-deficient environment of the host body, making iron-bound (ferric) siderophore complex uptake receptors potential useful targets for the immune system. In addition, previous screening experiments for novel T cell antigens showed the immunological potential of BfrD and BfrG, two extracellular ferric siderophore receptor proteins found on multiple strains of B. pertussis. In this study, we first show that BfrD and BfrG can be overexpressed in and purified from an E. coli mutant that lacks endotoxic lipopolysaccharide (LPS) via bacterial transformation so that LPS-removal measures that significantly reduce protein amount do not have to be taken. Second, we determined that the mutant LPS truly was not immunogenic, and so removal from the final protein solution was not necessary for use in murine models of infection. Finally, this study suggests immunization and boosting with BfrD adjuvated with alum (the adjuvant in the current aPV formulations) generates robust opsonizing capability, as well as possibly inducing a Th1 immune response and reducing bacterial burden in the nasal cavity.No embargoAcademic Major: BiochemistryAcademic Major: Mathematic

Evaluation of Syncope: An Overview

Syncope is defined as a sudden temporary loss of consciousness associated with a loss of postural tone, with spontaneous recovery that does not require electrical or chemical cardioversion. Syncope is a common symptom, accounting for 1% to 6% of hospital admission and up to 3% of emergency room visits. Loss of consciousness is also common in healthy young adults, although most do not seek medical attention. Syncope is a frequent symptom in the elderly. The evaluation and management of syncope has dramatically changed over the past 15 years. In the early 1980s, several studies showed that the cause of syncope was often not established, and subgroups were identified with high mortality and sudden death rates.1,2 ,3, 4 Later a large number of studies on electrophysiology testing appeared, which led to a better understanding of the roles and limitations of tests in syncope.5,6,7,8 Although tilt table testing started in 1980s, it assumed an important role in the evaluation of syncope in 1990s, showing that neurally mediated mechanism is a common etiology of unexplained syncope.9,10,11,12 The purpose of this article is to highlight the clinical approach and management of syncope

Identifying Security Risks in NFT Platforms

This paper examines the effects of inherent risks in the emerging technology of non-fungible tokens and proposes an actionable set of solutions for stakeholders in this ecosystem and observers. Web3 and NFTs are a fast-growing 300 billion dollar economy with some clear, highly publicized harms that came to light recently. We set out to explore the risks to understand their nature and scope, and if we could find ways to mitigate them. In due course of investigation, we recap the background of the evolution of the web from a client-server model to the rise of Web2.0 tech giants in the early 2000s. We contrast how the Web3 movement is trying to re-establish the independent style of the early web. In our research we discover a primary set of risks and harms relevant to the ecosystem, and classify them into a simple taxonomy while addressing their mitigations with solutions. We arrive at a set of solutions that are a combination of processes to be adopted, and technological changes or improvements to be incorporated into the ecosystem, to implement risk mitigations. By linking mitigations to individual risks, we are confident our recommendations will improve the security maturity of the growing Web3 ecosystem. We are not endorsing, or recommending specifically any particular product or service in our solution set. Nor are we compensated or influenced in any way by these companies to list these products in our research. The evaluations of products in our research have to simply be viewed as suggested improvements

Responsible AI (RAI) Games and Ensembles

Several recent works have studied the societal effects of AI; these include issues such as fairness, robustness, and safety. In many of these objectives, a learner seeks to minimize its worst-case loss over a set of predefined distributions (known as uncertainty sets), with usual examples being perturbed versions of the empirical distribution. In other words, aforementioned problems can be written as min-max problems over these uncertainty sets. In this work, we provide a general framework for studying these problems, which we refer to as Responsible AI (RAI) games. We provide two classes of algorithms for solving these games: (a) game-play based algorithms, and (b) greedy stagewise estimation algorithms. The former class is motivated by online learning and game theory, whereas the latter class is motivated by the classical statistical literature on boosting, and regression. We empirically demonstrate the applicability and competitive performance of our techniques for solving several RAI problems, particularly around subpopulation shift