UNDERSTANDING USAGE OF PUBLIC BIKE SHARING SYSTEM : CITI BIKE AS AN EXAMPLE

In recent years, bike sharing systems ushered in the explosive growth. The growth of bike sharing systems brings both health benefits and environmental benefits.This study is a data analysis project that investigate the usage pattern of bike sharing system using Citi Bike open source data. This study provide a demand prediction and gender prediction model. Also, this study studied the influence of weather and date on the demand of bike usage, and compare the characteristic usage pattern of two different gender group. With the comparison on usage of NY taxi, this study analysis when people prefer Citi Bike and verify that Citi Bike can be an ideal alternative transportation to taxis.Master of Science in Information Scienc

Practical Blind Denoising via Swin-Conv-UNet and Data Synthesis

While recent years have witnessed a dramatic upsurge of exploiting deep neural networks toward solving image denoising, existing methods mostly rely on simple noise assumptions, such as additive white Gaussian noise (AWGN), JPEG compression noise and camera sensor noise, and a general-purpose blind denoising method for real images remains unsolved. In this paper, we attempt to solve this problem from the perspective of network architecture design and training data synthesis. Specifically, for the network architecture design, we propose a swin-conv block to incorporate the local modeling ability of residual convolutional layer and non-local modeling ability of swin transformer block, and then plug it as the main building block into the widely-used image-to-image translation UNet architecture. For the training data synthesis, we design a practical noise degradation model which takes into consideration different kinds of noise (including Gaussian, Poisson, speckle, JPEG compression, and processed camera sensor noises) and resizing, and also involves a random shuffle strategy and a double degradation strategy. Extensive experiments on AGWN removal and real image denoising demonstrate that the new network architecture design achieves state-of-the-art performance and the new degradation model can help to significantly improve the practicability. We believe our work can provide useful insights into current denoising research.Comment: Codes: https://github.com/cszn/SCUNe

The roles of ubiquitination and deubiquitination of NLRP3 inflammasome in inflammation-related diseases: A review

The inflammatory response is a natural immune response that prevents microbial invasion and repairs damaged tissues. However, excessive inflammatory responses can lead to various inflammation-related diseases, posing a significant threat to human health. The NOD-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome is a vital mediator in the activation of the inflammatory cascade. Targeting the hyperactivation of the NLRP3 inflammasome may offer potential strategies for the prevention or treatment of inflammation-related diseases. It has been established that the ubiquitination and deubiquitination modifications of the NLRP3 inflammasome can provide protective effects in inflammation-related diseases. These modifications modulate several pathological processes, including excessive inflammatory responses, pyroptosis, abnormal autophagy, proliferation disorders, and oxidative stress damage. Therefore, this review discusses the regulation of NLRP3 inflammasome activation by ubiquitination and deubiquitination modifications, explores the role of these modifications in inflammation-related diseases, and examines the potential underlying mechanisms

Dynamics Analysis of Neuron Bursting under the Modulation of Periodic Stimulation

A nonsmooth neuron model with periodic excitation which can reproduce spiking and bursting behavior of cortical neurons is investigated in this paper. Based on nonsmooth bifurcation analysis, the mechanism of the bursting behavior induced by slow-changing periodical stimulation as well as the associated evolution with the variation of the stimulation is explored. The modulating character of the external excitation and the effect of the bifurcation occurring at the switching boundary of the vector field are presented

Myosin Light-Chain 4 Gene-Transfer Attenuates Atrial Fibrosis While Correcting Autophagic Flux Dysregulation

OBJECTIVES: To determine the role of MYL4 regulation of lysosomal function and its disturbance in fibrotic atrial cardiomyopathy. BACKGROUND: We have previously demonstrated that the atrial-specific essential light chain protein MYL4 is required for atrial contractile, electrical, and structural integrity. MYL4 mutation/dysfunction leads to atrial fibrosis, standstill, and dysrhythmia. However, the underlying pathogenic mechanisms remain unclear. METHODS AND RESULTS: Rats subjected to knock-in of a pathogenic MYL4 mutant (p.E11K) developed fibrotic atrial cardiomyopathy. Proteome analysis and single-cell RNA sequencing indicate enrichment of autophagy pathways in mutant-MYL4 atrial dysfunction. Immunofluorescence and electron microscopy revealed undegraded autophagic vesicles accumulated in MYL4 CONCLUSIONS: MYL4 regulates autophagic flux in atrial cardiomyocytes via lysosomal mobility. MYL4 overexpression attenuates MYL4 p.E11K induced fibrotic atrial cardiomyopathy, while correcting autophagy and lysosomal function. These results provide a molecular basis for MYL4-mutant induced fibrotic atrial cardiomyopathy and identify a potential biological-therapy approach for the treatment of atrial fibrosis

IL-34 Upregulated Th17 Production through Increased IL-6 Expression by Rheumatoid Fibroblast-Like Synoviocytes

Rheumatoid arthritis (RA) is a chronic autoimmune disease which is characterized by synovial inflammation and cartilage damage for which causes articular dysfunction. Activation of fibroblast-like synoviocytes (FLS) is a critical step that promotes disease progression. In this study, we aimed to explore the effect of interleukin-34 (IL-34) on RA FLS as a proinflammatory factor and IL-34-stimulated FLS on the production of Th17. We found that serum IL-34 levels were increased compared to those of the healthy controls and had positive correlations with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), and anticyclic citrullinated peptide (CCP) antibody accordingly. CSF-1R was also highly expressed on RA FLS. The interaction of IL-34 and CSF-1R promoted a dramatic production of IL-6 by FLS through JNK/P38/NF-κB signaling pathway. Further, the IL-34-stimulated IL-6 secretion by RA FLS was found to upregulate the number of Th17. The treatment of IL-6R antagonist could attenuate the production of Th17 mediated by IL-34-stimulated RA FLS. Our results suggest that the increased IL-34 levels were closely related to the disease activity of RA. Additionally, the overexpression of IL-6 in the IL-34-stimulated FLS promoted the generation of Th17. Therefore, IL-34 was supposed to be involved in the pathogenesis of RA. The inhibition of IL-34 might provide a novel target for therapies of RA

Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst

The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl] 2 in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h -1 ) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asymmetric hydrogenation of trisubstituted pyridines with nearly quantitative yields and up to 98% ee. In these two reactions, the addition of I 2 additive is indispensable; but the amount of I 2 has a different effect on catalytic performance