Acupuncture for cancer pain in adults.

BACKGROUND: Forty percent of individuals with early or intermediate stage cancer and 90% with advanced cancer have moderate to severe pain and up to 70% of patients with cancer pain do not receive adequate pain relief. It has been claimed that acupuncture has a role in management of cancer pain and guidelines exist for treatment of cancer pain with acupuncture. OBJECTIVES: To evaluate efficacy of acupuncture for relief of cancer-related pain in adults. SEARCH STRATEGY: CENTRAL, MEDLINE, EMBASE, PsycINFO, AMED, and SPORTDiscus were searched up to November 2010 including non-English language papers. SELECTION CRITERIA: Randomised controlled trials (RCTs) evaluating any type of invasive acupuncture for pain directly related to cancer in adults of 18 years or over. DATA COLLECTION AND ANALYSIS: It was planned to pool data to provide an overall measure of effect and to calculate the number needed to treat to benefit, but this was not possible due to heterogeneity. Two review authors (CP, OT) independently extracted data adding it to data extraction sheets. Quality scores were given to studies. Data sheets were compared and discussed with a third review author (MJ) who acted as arbiter. Data analysis was conducted by CP, OT and MJ. MAIN RESULTS: Three RCTs (204 participants) were included. One high quality study investigated the effect of auricular acupuncture compared with auricular acupuncture at 'placebo' points and with non-invasive vaccaria ear seeds attached at 'placebo' points. Participants in two acupuncture groups were blinded but blinding wasn't possible in the ear seeds group because seeds were attached using tape. This may have biased results in favour of acupuncture groups. Participants in the real acupuncture group had lower pain scores at two month follow-up than either the placebo or ear seeds group.There was high risk of bias in two studies because of low methodological quality. One study comparing acupuncture with medication concluded that both methods were effective in controlling pain, although acupuncture was the most effective. The second study compared acupuncture, point-injection and medication in participants with stomach cancer. Long-term pain relief was reported for both acupuncture and point-injection compared with medication during the last 10 days of treatment. Although both studies have positive results in favour of acupuncture they should be viewed with caution due to methodological limitations, small sample sizes, poor reporting and inadequate analysis. AUTHORS' CONCLUSIONS: There is insufficient evidence to judge whether acupuncture is effective in treating cancer pain in adults

An Empirical Analysis on Purchase Intention on Coffee Beverage in Taiwan

Coffee is the most popular beverage in the world. However, in Taiwan, coffee is a second option for beverage choice after tea, which is the traditional beverage of this nation. Under the impact of Western culture, the habit of Taiwanese on beverage has become gradually change. In the recent years, the rapid growth of the various coffee supply channels such as coffee shop, coffee chains, fast food restaurants and convenience stores has assisted in creating a huge market for consumption coffee. Thus, understanding consumer’s habit on coffee purchasing in non-coffee drinking habit market is crucial. It can offer some important information for coffee suppliers to formulate their market strategies in Taiwan. Therefore, in this study, the determinants of Taiwanese coffee drinker in purchasing coffee are defined. Results from 260 respondents were analysed by exploratory factor analysis and regression analysis. The findings demonstrate that brand & price, product image, promotion & advertising, motivation, atmosphere & environment and taste are critical factors which impact on coffee drinker’s purchase intention. Among that, promotion & advertising plays the principal role to attract customers. Therefore, in order to create competitive advantages in the coffee beverage industry, the actions of promotion and advertising should be strong by coffee supplier. Besides, how to produce high quality of coffee beverages and maintain to meet the requirements of drinker's for good flavor and taste also must be considered. Keywords: coffee beverage, purchase intention, Taiwa

Design and Research of Intelligent Remote Control Fan Based on Single Chip Microcomputer and Bluetooth Technology

This paper is designed for intelligent remote control fans. The design of the microcontroller as the core, the sensor, Bluetooth and Andrews system applied to the design of intelligent remote control fan. According to the temperature sensor to achieve the indoor temperature collection, to achieve and set the temperature comparison, thus affecting the fan speed. At the same time, the system according to the infrared sensor components to detect external factors, in order to achieve the running or stopping of the fan, that is, to achieve intelligent control of the fan. In addition, the system achieve the Bluetooth and mobile phone Andrews system of effective combination, and through the software program to complete the fan remote operation and wind speed control

Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease

Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and immune cell function that are driven, at least in part, by infection. Analysis of parainfluenza virus infection in mice revealed an unexpected role for innate immune cells in IL-13–dependent chronic lung disease, but the upstream driver for the immune axis in this model and in humans with similar disease was undefined. We demonstrate here that lung levels of IL-33 are selectively increased in postviral mice with chronic obstructive lung disease and in humans with very severe chronic obstructive pulmonary disease (COPD). In the mouse model, IL-33/IL-33 receptor signaling was required for Il13 and mucin gene expression, and Il33 gene expression was localized to a virus-induced subset of airway serous cells and a constitutive subset of alveolar type 2 cells that are both linked conventionally to progenitor function. In humans with COPD, IL33 gene expression was also associated with IL13 and mucin gene expression, and IL33 induction was traceable to a subset of airway basal cells with increased capacities for pluripotency and ATP-regulated release of IL-33. Together, these findings provide a paradigm for the role of the innate immune system in chronic disease based on the influence of long-term epithelial progenitor cells programmed for excess IL-33 production

A novel HIV-1 restriction factor that is biologically distinct from APOBEC3 cytidine deaminases in a human T cell line CEM.NKR

<p>Abstract</p> <p>Background</p> <p>Isolation of novel retroviral restriction factors will open new avenues for anti-HIV/AIDS treatment. Although HIV-1 replication is restricted by APOBEC3G/APOBEC3F, TRIM5α, and CD317, none defend HIV-1 infection under natural conditions. Previously, we demonstrated a host factor from the human T cell line CEM.NKR that potently restricted wild-type HIV-1 replication. Interestingly, this restriction resembled the APOBEC3G/APOBEC3F pattern in that viral replication was inhibited from the second round of replication cycle at a post-entry step.</p> <p>Results</p> <p>Here, we further characterized this factor and found it distinguishable from the known anti-HIV APOBEC3 proteins. Although CEM.NKR cells expressed both APOBEC3G and APOBEC3F, their levels were at least 10 or 4-fold lower than those in H9 cells, and importantly, Vif effectively neutralized their activity. Among eight subclones isolated from CEM.NKR cells, one was relatively permissive, four were semi-permissive, and three were completely non-permissive for HIV-1 replication. When the levels of APOBEC3 expression were determined, all these clones retained similar low levels of APOBEC3DE, APOBEC3F, APOBEC3G and APOBEC3H expression, and no APOBEC3B expression was detected. Since the <it>vif </it>from SIVmac can effectively neutralize APOBEC3B and APOBEC3H, recombinant HIV-1 expressing this SIV gene were created. However, these viruses still failed to replicate in CEM.NKR cells. We also confirmed that HIV-1 restriction in CEM.NKR was not due to a loss of calnexin expression.</p> <p>Conclusion</p> <p>Taken together, these results not only demonstrate that all these aforementioned anti-HIV APOBEC3 proteins do not contribute to this HIV-1 restriction, but also shed light on a novel and potent HIV-1 inhibitor in CEM.NKR cells.</p

Emphasizing Crucial Features for Efficient Image Restoration

Image restoration is a challenging ill-posed problem which estimates latent sharp image from its degraded counterpart. Although the existing methods have achieved promising performance by designing novelty architecture of module, they ignore the fact that different regions in a corrupted image undergo varying degrees of degradation. In this paper, we propose an efficient and effective framework to adapt to varying degrees of degradation across different regions for image restoration. Specifically, we design a spatial and frequency attention mechanism (SFAM) to emphasize crucial features for restoration. SFAM consists of two modules: the spatial domain attention module (SDAM) and the frequency domain attention module (FDAM). The SFAM discerns the degradation location through spatial selective attention and channel selective attention in the spatial domain, while the FDAM enhances high-frequency signals to amplify the disparities between sharp and degraded image pairs in the spectral domain. Additionally, to capture global range information, we introduce a multi-scale block (MSBlock) that consists of three scale branches, each containing multiple simplified channel attention blocks (SCABlocks) and a multi-scale feed-forward block (MSFBlock). Finally, we propose our ECFNet, which integrates the aforementioned components into a U-shaped backbone for recovering high-quality images. Extensive experimental results demonstrate the effectiveness of ECFNet, outperforming state-of-the-art (SOTA) methods on both synthetic and real-world datasets