Evidence for strong electron-phonon coupling and polarons in the optical response of La_{2-x}Sr_xCuO_4

The normal state optical response of La_{2-x}Sr_xCuO_4 is found to be consistent with a simple multi-component model, based on free carriers with strong electron-phonon interaction, localized polaronic states near 0.15 eV and a mid-infrared band at 0.5 eV. Normal state reflectance and absorbance of La_{1.83}Sr_{0.17}CuO_4 are investigated and their temperature dependence is explained. Both, the ac and dc response are recovered and the quasi-linear behavior of the optical scattering rate up to 3000- 4000 cm^{-1} is found to be consistent with strong electron-phonon interaction, which also accounts for the value of T_c. Although not strictly applicable in the superconducting state, our simple model accounts for the observed penetration depth and the optical response below T_c can be recovered by introducing a small amount of additional carriers. Our findings suggest that the optical response of La_{2-x}Sr_xCuO_4 could be explained both, in the normal and superconducting state, by a simple multi-fluid model with strong electron-phonon interaction if the gap symmetry and the temperature dependence of the 0.5 eV mid-infrared band are adequately taken into account.Comment: 22 pages, REVTeX, 12 figures in ps-fil

Reply to the Letter to the Editor: Quantitative accuracy of virtual monoenergetic images from multi-energy CT

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First Experience With a Whole-Body Spectral Photon-Counting CT Clinical Prototype

International audienceAbstract Spectral photon-counting computed tomography (SPCCT) technology holds great promise for becoming the next generation of computed tomography (CT) systems. Its technical characteristics have many advantages over conventional CT imaging. For example, SPCCT provides better spatial resolution, greater dose efficiency for ultra-low-dose and low-dose protocols, and tissue contrast superior to that of conventional CT. In addition, SPCCT takes advantage of several known approaches in the field of spectral CT imaging, such as virtual monochromatic imaging and material decomposition imaging. In addition, SPCCT takes advantage of a new approach in this field, known as K-edge imaging, which allows specific and quantitative imaging of a heavy atom-based contrast agent. Hence, the high potential of SPCCT systems supports their ongoing investigation in clinical research settings. In this review, we propose an overview of our clinical research experience of a whole-body SPCCT clinical prototype, to give an insight into the potential benefits for clinical human imaging on image quality, diagnostic confidence, and new approaches in spectral CT imaging

Feasibility of using post-contrast dual-energy CT for pediatric radiation treatment planning and dose calculation

Objectives: When iodinated contrast is administered during CT simulation, standard practice requires a separate non-contrast CT for dose calculation. The objective of this study is to validate our hypothesis that since iodine affects Hounsfield units (HUs) more than electron density (ED), the information from post-contrast dual-layer CT (DLCT) would be sufficient for accurate dose calculation for both photon and proton therapy. Methods and materials: 10 pediatric patients with abdominal tumors underwent DLCT scans before and after iodinated contrast administration for radiotherapy planning. Dose distributions with these DLCT-based methods were compared to those with conventional calibration-curve methods that map HU images to ED and stopping-power ratio (SPR) images. Results: For photon plans, conventional and DLCT approaches based on post-contrast scans underestimated the PTV D99 by 0.87 ± 0.70% (p = 0.18) and 0.36 ± 0.31% (p = 0.34), respectively, comparing to their non-contrast optimization plans. Renal iodine concentration was weakly associated with D99 deviation for both conventional (R2 = 0.10) and DLCT (R2 = 0.02) approaches. For proton plans, the clinical target volume D99 errors were 3.67 ± 2.43% (p = 0.0001) and 0.30 ± 0.25% (p = 0.40) for conventional and DLCT approaches, respectively. The proton beam range changed noticeably with the conventional approach. Renal iodine concentration was highly associated with D99 deviation for the conventional approach (R2 = 0.83) but not for DLCT (R2 = 0.007). Conclusion: Conventional CT with iodine contrast resulted in a large dosimetric error for proton therapy, compared to true non-contrast plans, but the error was less for photon therapy. These errors can be greatly reduced in the case of the proton plans if DLCT is used, raising the possibility of using only a single post-contrast CT for radiotherapy dose calculation, thus reducing the time and imaging dose required. Advances in knowledge: This study is the first to compare directly the differences in the calculated dose distributions between pre- and post-contrast CT images generated by single-energy CT and dual-energy CT methods for photon and proton therapy. </jats:sec