3,681 research outputs found
Probing the Electronic States in Black Phosphorus Vertical Heterostructures
Atomically thin black phosphorus (BP) is a promising two-dimensional material
for fabricating electronic and optoelectronic nano-devices with high mobility
and tunable bandgap structures. However, the charge-carrier mobility in
few-layer phosphorene (monolayer BP) is mainly limited by the presence of
impurity and disorders. In this study, we demonstrate that vertical BP
heterostructure devices offer great advantages in probing the electron states
of monolayer and few-layer phosphorene at temperatures down to 2 K through
capacitance spectroscopy. Electronic states in the conduction and valence bands
of phosphorene are accessible over a wide range of temperature and frequency.
Exponential band tails have been determined to be related to disorders. Unusual
phenomena such as the large temperature-dependence of the electron state
population in few-layer phosphorene have been observed and systematically
studied. By combining the first-principles calculation, we identified that the
thermal excitation of charge trap states and oxidation-induced defect states
were the main reasons for this large temperature dependence of the electron
state population and degradation of the on-off ratio in phosphorene
field-effect transistors.Comment: 15 pages, 7 figures, 2D Materials, Volume 3, Number 1(2016
Efficient derivation of dopaminergic neurons from SOX1(-) floor plate cells under defined culture conditions.
BACKGROUND: Parkinson's disease (PD) is a severe neurodegenerative disease associated with loss of dopaminergic neurons. Derivation of dopaminergic neurons from human embryonic stem cells (hESCs) could provide new therapeutic options for PD therapy. Dopaminergic neurons are derived from SOX(-) floor plate (FP) cells during embryonic development in many species and in human cell culture in vitro. Early treatment with sonic hedgehog (Shh) has been reported to efficiently convert hESCs into FP lineages. METHODS: In this study, we attempted to utilize a Shh-free approach in deriving SOX1(-) FP cells from hESCs in vitro. Neuroectoderm conversion from hESCs was achieved with dual inhibition of the BMP4 (LDN193189) and TGF-β signaling pathways (SB431542) for 24 h under defined culture conditions. RESULTS: Following a further 5 days of treatment with LDN193189 or LDN193189 + SB431542, SOX1(-) FP cells constituted 70-80 % of the entire cell population. Upon treatment with Shh and FGF8, the SOX1(-) FP cells were efficiently converted to functional Nurr1(+) and TH(+) dopaminergic cells (patterning), which constituted more than 98 % of the entire cell population. However, when the same growth factors were applied to SOX1(+) cells, only less than 4 % of the cells became Nurr1(+), indicating that patterning was effective only if SOX1 expression was down-regulated. After transplanting the Nurr1(+) and TH(+) cells into a hemiparkinsonian rat model, significant improvements were observed in amphetamine induced ipslateral rotations, apomorphine induced contra-lateral rotations and Rota rod motor tests over a duration of 8 weeks. CONCLUSIONS: Our findings thus provide a convenient approach to FP development and functional dopaminergic neuron derivation.published_or_final_versio
Transcatheter arterial chemoembolization combined with radiofrequency ablation delays tumor progression and prolongs overall survival in patients with intermediate (BCLC B) hepatocellular carcinoma
Research on sound insulation characteristics of the friction stir welding magnesium alloy sheet
The friction stir welding (FSW) on magnesium alloy has already been widely used. Therefore, the research on its sound insulation characteristics appears particularly significant, based on ALE (Arbitrary Lagrangian Eulerian) adaptive meshing technique of ABAQUS/Explicit, the FSW procedure was numerically simulated and the modal solution, just a little different from the experimental result, was finally obtained, which has verified the validity of the established model, and obtain the response result to be imported into professional acoustic software to calculate the sound insulation characteristics. Subsequently, the structure-acoustic coupling method was employed to calculate the noise reduction in FSW on magnesium alloy, and through comparison with the experimental result, this coupling method proved feasible to predict the sound insulation characteristics in FSW on magnesium alloy. Furthermore, the result has also revealed that FSW could increase the noise reduction at intermediate or low frequency, in addition, which was 2 dB higher on the frontal welding surface than the reverse one. Consequently, at the installation of magnesium alloy welding parts, the frontal or reverse surface shall be reasonably selected to face the noise source in accordance with the practical situation, so as to improve the sound insulation performance to a greater extent. To some extent, the research achieves the combination of welding and acoustic
Manipulation of magnetic systems by quantized surface acoustic wave via piezomagnetic effect
The quantized surface acoustic wave (SAW) in the piezoelectric medium has
recently been studied, and is used to control electric dipoles of quantum
systems via the electric field produced through piezoelectric effect. However,
it is not easy and convenient to manipulate magnetic moments directly by the
electric field. We here study a quantum theory of SAW in the piezomagnetic
medium. We show that the intrinsic properties of the piezomagnetic medium
enable the SAW in the piezomagnetic medium to directly interact with magnetic
moments of quantum systems via magnetic field induced by piezomagnetic effect.
By taking the strip SAW waveguide made of piezomagnetic medium as an example,
we further study the coupling strengths between different magnetic quantum
systems with magnetic moments and the quantized single-mode SAW in the
waveguide. Based on this, we discuss the interaction between magnetic quantum
systems mediated by the quantized multi-mode SAW in piezomagnetic waveguide.
Our study provides a convenient way to directly control magnetic quantum
systems by quantized SAW, and offers potential applications to on-chip
information processing based on solid-state quantum systems via quantized
acoustic wave.Comment: 16 pages, 10 figure
Physics perspectives of heavy-ion collisions at very high energy
Heavy-ion collisions at very high colliding energies are expected to produce
a quark-gluon plasma (QGP) at the highest temperature obtainable in a
laboratory setting. Experimental studies of these reactions can provide an
unprecedented range of information on properties of the QGP at high
temperatures. We report theoretical investigations of the physics perspectives
of heavy-ion collisions at a future high-energy collider. These include initial
parton production, collective expansion of the dense medium, jet quenching,
heavy-quark transport, dissociation and regeneration of quarkonia, photon and
dilepton production. We illustrate the potential of future experimental studies
of the initial particle production and formation of QGP at the highest
temperature to provide constraints on properties of strongly interaction
matter.Comment: 35 pages in Latex, 29 figure
The CDEX-1 1 kg Point-Contact Germanium Detector for Low Mass Dark Matter Searches
The CDEX Collaboration has been established for direct detection of light
dark matter particles, using ultra-low energy threshold p-type point-contact
germanium detectors, in China JinPing underground Laboratory (CJPL). The first
1 kg point-contact germanium detector with a sub-keV energy threshold has been
tested in a passive shielding system located in CJPL. The outputs from both the
point-contact p+ electrode and the outside n+ electrode make it possible to
scan the lower energy range of less than 1 keV and at the same time to detect
the higher energy range up to 3 MeV. The outputs from both p+ and n+ electrode
may also provide a more powerful method for signal discrimination for dark
matter experiment. Some key parameters, including energy resolution, dead time,
decay times of internal X-rays, and system stability, have been tested and
measured. The results show that the 1 kg point-contact germanium detector,
together with its shielding system and electronics, can run smoothly with good
performances. This detector system will be deployed for dark matter search
experiments.Comment: 6 pages, 8 figure
A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III
We established a method on measuring the \dzdzb mixing parameter for
BESIII experiment at the BEPCII collider. In this method, the doubly
tagged events, with one decays to
CP-eigenstates and the other decays semileptonically, are used to
reconstruct the signals. Since this analysis requires good separation,
a likelihood approach, which combines the , time of flight and the
electromagnetic shower detectors information, is used for particle
identification. We estimate the sensitivity of the measurement of to be
0.007 based on a fully simulated MC sample.Comment: 6 pages, 7 figure
CoLLD: Contrastive Layer-to-layer Distillation for Compressing Multilingual Pre-trained Speech Encoders
Large-scale self-supervised pre-trained speech encoders outperform
conventional approaches in speech recognition and translation tasks. Due to the
high cost of developing these large models, building new encoders for new tasks
and deploying them to on-device applications are infeasible. Prior studies
propose model compression methods to address this issue, but those works focus
on smaller models and less realistic tasks. Thus, we propose Contrastive
Layer-to-layer Distillation (CoLLD), a novel knowledge distillation method to
compress pre-trained speech encoders by leveraging masked prediction and
contrastive learning to train student models to copy the behavior of a large
teacher model. CoLLD outperforms prior methods and closes the gap between small
and large models on multilingual speech-to-text translation and recognition
benchmarks.Comment: Submitted to ICASSP 202
Terrestrial water storage anomalies emphasize interannual variations in global mean sea level during 1997-1998 and 2015-2016 El Nino Events
© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Kuo, Y.-N., Lo, M.-H., Liang, Y.-C., Tseng, Y.-H., & Hsu, C.-W. Terrestrial water storage anomalies emphasize interannual variations in global mean sea level during 1997-1998 and 2015-2016 El Nino Events. Geophysical Research Letters, 48(18), (2021): e2021GL094104, https://doi.org/10.1029/2021GL094104.Interannual variations in global mean sea level (GMSL) closely correlate with the evolution of El Niño-Southern Oscillation. However, GMSL differences occur in extreme El Niños; for example, in the 2015–2016 and 1997–1998 El Niños, the peak GMSL during the mature stage of the former (9.00 mm) is almost 2.5 times higher than the latter (3.72 mm). Analyses from satellite and reanalysis data sets show that the disparity in GMSL is primarily due to barystatic (ocean mass) changes. We find that the 2015–2016 event developed not purely as an Eastern Pacific El Niño event but with Central Pacific (CP) El Niño forcing. CP El Niños contribute to a stronger negative anomaly of global terrestrial water storage and subsequent higher barystatic heights. Our results suggest that the mechanism of hydrology-related interannual variations of GMSL should be further emphasized, as more CP El Niño events are projected to occur.This study was supported by a grant of MOST 106-2111-M-002-010-MY4 to National Taiwan University
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