STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS.

During epithelium tissue maintenance, lineages of cells differentiate and proliferate in a coordinated way to provide the desirable size and spatial organization of different types of cells. While mathematical models through deterministic description have been used to dissect role of feedback regulations on tissue layer size and stratification, how the stochastic effects influence tissue maintenance remains largely unknown. Here we present a stochastic continuum model for cell lineages to investigate how both layer thickness and layer stratification are affected by noise. We find that the cell-intrinsic noise often causes reduction and oscillation of layer size whereas the cell-extrinsic noise increases the thickness, and sometimes, leads to uncontrollable growth of the tissue layer. The layer stratification usually deteriorates as the noise level increases in the cell lineage systems. Interestingly, the morphogen noise, which mixes both cell-intrinsic noise and cell-extrinsic noise, can lead to larger size of layer with little impact on the layer stratification. By investigating different combinations of the three types of noise, we find the layer thickness variability is reduced when cell-extrinsic noise level is high or morphogen noise level is low. Interestingly, there exists a tradeoff between low thickness variability and strong layer stratification due to competition among the three types of noise, suggesting robust layer homeostasis requires balanced levels of different types of noise in the cell lineage systems

The study of consumption patterns and expectations of organic catering consumers in Taiwan

This report was presented at the UK Organic Research 2002 Conference. Organic catering is increasingly provided in public and private food services. In Taiwan, most organic catering is vegetarian and affiliated with organic food stores. These offer diners organic meals to make themselves competitive to attract target markets, and provide related information to improve consumers’ knowledge of organic foods and hopefully increase their consumption. Organic catering consumers’ knowledge of organic foods, attitudes toward consumption, and consumption behavior are all related. Consumption is affected by gender, marital status, age, religion, education, occupation, personal health, family health and expenditure allowance. Regular organic catering customers emphasize “balanced nutrition” and “certification or reliability of organic sources”. The obstacles to consumption for non-regular organic catering consumers are “too expensive” and “difficult to find”. Most organic catering consumers prefer the service styles “health-themed restaurant” and “located inside the organic food stores”

A HYBRID METHOD FOR STIFF REACTION-DIFFUSION EQUATIONS.

The second-order implicit integration factor method (IIF2) is effective at solving stiff reaction-diffusion equations owing to its nice stability condition. IIF has previously been applied primarily to systems in which the reaction contained no explicitly time-dependent terms and the boundary conditions were homogeneous. If applied to a system with explicitly time-dependent reaction terms, we find that IIF2 requires prohibitively small time-steps, that are relative to the square of spatial grid sizes, to attain its theoretical second-order temporal accuracy. Although the second-order implicit exponential time differencing (iETD2) method can accurately handle explicitly time-dependent reactions, it is more computationally expensive than IIF2. In this paper, we develop a hybrid approach that combines the advantages of both methods, applying IIF2 to reaction terms that are not explicitly time-dependent and applying iETD2 to those which are. The second-order hybrid IIF-ETD method (hIFE2) inherits the lower complexity of IIF2 and the ability to remain second-order accurate in time for large time-steps from iETD2. Also, it inherits the unconditional stability from IIF2 and iETD2 methods for dealing with the stiffness in reaction-diffusion systems. Through a transformation, hIFE2 can handle nonhomogeneous boundary conditions accurately and efficiently. In addition, this approach can be naturally combined with the compact and array representations of IIF and ETD for systems in higher spatial dimensions. Various numerical simulations containing linear and nonlinear reactions are presented to demonstrate the superior stability, accuracy, and efficiency of the new hIFE method

Code Prediction by Feeding Trees to Transformers

We advance the state-of-the-art in the accuracy of code prediction (next token prediction) used in autocomplete systems. First, we report that using the recently proposed Transformer architecture even out-of-the-box outperforms previous neural and non-neural systems for code prediction. We then show that by making the Transformer architecture aware of the syntactic structure of code, we further increase the margin by which a Transformer-based system outperforms previous systems. With this, it outperforms the accuracy of an RNN-based system (similar to Hellendoorn et al. 2018) by 18.3\%, the Deep3 system (Raychev et al 2016) by 14.1\%, and an adaptation of Code2Seq (Alon et al., 2018) for code prediction by 14.4\%. We present in the paper several ways of communicating the code structure to the Transformer, which is fundamentally built for processing sequence data. We provide a comprehensive experimental evaluation of our proposal, along with alternative design choices, on a standard Python dataset, as well as on a Facebook internal Python corpus. Our code and data preparation pipeline will be available in open source

Subject Assessment of Thermal Transition in a Museum: a Case Study

Thermal sensation and comfort evaluation schemes typically address thermally adapted people under static circumstances. A disregard of thermal evaluation processes pertaining to transitional states may result in inappropriate temperature settings, inefficient thermal control, and poor thermal comfort. Thus, recently studies have been carried out, which consider thermal perception under dynamic (transitional) conditions. This paper represents an example of such a study. It investigates people's subjective thermal sensation assessment immediately after a spatial transition, i.e., entering or exiting a building or moving between different spaces within a building. Field experiments were conducted in the Museum of Art History (Kunsthistorisches Museum) in Vienna, Austria. Multiple groups of participants moved through a predefined route throughout the building. This route involved five spatial transitions. Immediately after each transition, the participants expressed their thermal sensation vote (TSV) via a questionnaire. Participants' responses were analyzed in the context of monitored temperature differences between the spaces along the participants' route through the building

Energy regeneration from suspension dynamic modes and self-powered actuation

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.This paper concerns energy harvesting from vehicle suspension systems. The generated power associated with bounce, pitch and roll modes of vehicle dynamics is determined through analysis. The potential values of power generation from these three modes are calculated. Next, experiments are carried out using a vehicle with a four jack shaker rig to validate the analytical values of potential power harvest. For the considered vehicle, maximum theoretical power values of 1.1kW, 0.88kW and 0.97kW are associated with the bounce, pitch and roll modes, respectively, at 20 Hz excitation frequency and peak to peak displacement amplitude of 5 mm at each wheel, as applied by the shaker. The corresponding experimentally power values are 0.98kW, 0.74kW and 0.78kW. An experimental rig is also developed to study the behavior of regenerative actuators in generating electrical power from kinetic energy. This rig represents a quarter-vehicle suspension model where the viscous damper in the shock absorber system is replaced by a regenerative system. The rig is able to demonstrate the actual electrical power that can be harvested using a regenerative system. The concept of self-powered actuation using the harvested energy from suspension is discussed with regard to applications of self-powered vibration control. The effect of suspension energy regeneration on ride comfort and road handling is presented in conjunction with energy harvesting associated with random road excitations.Peer reviewedFinal Accepted Versio