Charney Hall Redesign Using Cross-Laminated Timber

Santa Clara University’s new law building, Charney Hall, was constructed in 2018 using steel and concrete, but was redesigned by this team using Cross-Laminated Timber (CLT) and Glue- Laminated Timber (glulams). Charney Hall is a non-symmetric, incongruent structure with large open rooms up to 6,000 square feet. Glulams are made of several parallel planks of wood glued together with structural epoxy to obtain higher strength in the longitudinal direction. CLT panels are similar to glulams, but the longitudinal grains of wood planks are oriented in perpendicular layers in order to increase strength along the weak and strong axes of the member. These engineered wood products capture the strength and longevity of steel and concrete while lowering the environmental impact during the manufacturing and construction process, so the purpose of this design was to show the applicability of these materials in the United States. The completion of this design required an understanding of product information and material properties provided by manufacturers such as Structurlam along with an understanding of the fire, seismic, and safety research that a few organizations, such as Portland and Oregon State Universities, have conducted. This structural redesign included the design of the gravity system by way of the glulam beams and columns and the CLT floor diaphragms. It also included the design of CLT shear walls for the lateral system and a few poignant connection designs

Expression and Functional Studies on the Noncoding RNA, PRINS.

PRINS, a noncoding RNA identified earlier by our research group, contributes to psoriasis susceptibility and cellular stress response. We have now studied the cellular and histological distribution of PRINS by using in situ hybridization and demonstrated variable expressions in different human tissues and a consistent staining pattern in epidermal keratinocytes and in vitro cultured keratinocytes. To identify the cellular function(s) of PRINS, we searched for a direct interacting partner(s) of this stress-induced molecule. In HaCaT and NHEK cell lysates, the protein proved to be nucleophosmin (NPM) protein as a potential physical interactor with PRINS. Immunohistochemical experiments revealed an elevated expression of NPM in the dividing cells of the basal layers of psoriatic involved skin samples as compared with healthy and psoriatic uninvolved samples. Others have previously shown that NPM is a ubiquitously expressed nucleolar phosphoprotein which shuttles to the nucleoplasm after UV-B irradiation in fibroblasts and cancer cells. We detected a similar translocation of NPM in UV-B-irradiated cultured keratinocytes. The gene-specific silencing of PRINS resulted in the retention of NPM in the nucleolus of UV-B-irradiated keratinocytes; suggesting that PRINS may play a role in the NPM-mediated cellular stress response in the skin

Task Force Rattlesnake: A Cost Analysis of Fire Crew Base Pay in California

Wildfire management in California is an expensive program totaling over $3 billion in 2020, where the state provides two-thirds of the budget from the general fund (Peters et al., 2020). California has consistently used the state military to assist in wildland fire mitigation efforts; however, for the first time it has created a year-round team to reduce fuels to clean up the state’s forests. Further analysis would determine if Task Force Rattlesnake is an effective use of the state’s budget for wildfire mitigation

Frontier discord between Afghanistan and Pakistan

Written in reply to article of Sir George Cunningham entitled Frontier discord: Pakistan and Afghanistan which appeared in the Manchester Guardian[n.d] of p. [1].Includes Regarding the views of Sir George Cunningham by Saidal Yusufzai: p. [1]-8, at end of book

Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma

Published in final edited form as: Sci Transl Med. 2017 May 10; 9(389). https://doi.org/10.1126/scitranslmed.aal2668.Multiple myeloma (MM) is a frequently incurable hematological cancer in which overactivity of MYC plays a central role, notably through up-regulation of ribosome biogenesis and translation. To better understand the oncogenic program driven by MYC and investigate its potential as a therapeutic target, we screened a chemically diverse small-molecule library for anti-MM activity. The most potent hits identified were rocaglate scaffold inhibitors of translation initiation. Expression profiling of MM cells revealed reversion of the oncogenic MYC-driven transcriptional program by CMLD010509, the most promising rocaglate. Proteome-wide reversion correlated with selective depletion of short-lived proteins that are key to MM growth and survival, most notably MYC, MDM2, CCND1, MAF, and MCL-1. The efficacy of CMLD010509 in mouse models of MM confirmed the therapeutic relevance of these findings in vivo and supports the feasibility of targeting the oncogenic MYC-driven translation program in MM with rocaglates

16 Years of US Presence in Afghanistan: Objectives, Strategies and Emerging Scenario

This write-up is based largely on a lecture given by the author at the Institute of Policy Studies, Islamabad on October 05, 2017