612 research outputs found
Metabolic syndrome is independently associated with increased 20-year mortality in patients with stable coronary artery disease
Emergent Phenomena Induced by Spin-Orbit Coupling at Surfaces and Interfaces
Spin-orbit coupling (SOC) describes the relativistic interaction between the
spin and momentum degrees of freedom of electrons, and is central to the rich
phenomena observed in condensed matter systems. In recent years, new phases of
matter have emerged from the interplay between SOC and low dimensionality, such
as chiral spin textures and spin-polarized surface and interface states. These
low-dimensional SOC-based realizations are typically robust and can be
exploited at room temperature. Here we discuss SOC as a means of producing such
fundamentally new physical phenomena in thin films and heterostructures. We put
into context the technological promise of these material classes for developing
spin-based device applications at room temperature
Characteristics and outcomes of diabetic patients with an implantable cardioverter defibrillator in a real world setting: results from the Israeli ICD registry
AIMS: There are limited data regarding the effect of diabetes mellitus (DM) on the risks of both appropriate and inappropriate implantable cardioverter defibrillator (ICD) therapy. The present study was designed to compare the outcome of appropriate and inappropriate ICD therapy in patients with or without DM. METHODS AND RESULTS: The risk of a first appropriate ICD therapy for ventricular tachyarrhythmias (including anti tachycardia pacing and shock) was compared between 764 DM and 1346 non-DM patients enrolled in the national Israeli ICD registry. We also compared the risks of inappropriate ICD therapy, and death or cardiac hospitalization between diabetic and non-diabetic patients. Diabetic patients were older, were more likely to have ischemic cardiomyopathy, lower ejection fraction, atrial fibrillation, and other co-morbidities. The 3-year cumulative incidence of appropriate ICD therapy was similar in the DM and non-DM groups (12 and 13%, respectively, p = 0.983). Multivariate analysis showed that DM did not affect the risk of appropriate ICD therapy (HR = 1.07, 95% CI 0.78–1.47, p = 0.694) or inappropriate therapy (HR = 0.72, 95% CI 0.42–1.23, p = 0.232). However, DM was associated with a 31% increased risk for death or cardiac hospitalization (p = 0.005). Results were similar in subgroup analyses including ICD and defibrillators with cardiac resynchronization therapy function recipients, primary or secondary prevention indication for an ICD. CONCLUSIONS: Despite a significant excess of cardiac hospitalizations and mortality in the diabetic population, there was no difference in the rate of ICD treatments, suggesting that the outcome difference is not related to arrhythmias
Algebraic Comparison of Partial Lists in Bioinformatics
The outcome of a functional genomics pipeline is usually a partial list of
genomic features, ranked by their relevance in modelling biological phenotype
in terms of a classification or regression model. Due to resampling protocols
or just within a meta-analysis comparison, instead of one list it is often the
case that sets of alternative feature lists (possibly of different lengths) are
obtained. Here we introduce a method, based on the algebraic theory of
symmetric groups, for studying the variability between lists ("list stability")
in the case of lists of unequal length. We provide algorithms evaluating
stability for lists embedded in the full feature set or just limited to the
features occurring in the partial lists. The method is demonstrated first on
synthetic data in a gene filtering task and then for finding gene profiles on a
recent prostate cancer dataset
Are Mendeley Reader Counts Useful Impact Indicators in all Fields?
Reader counts from the social reference sharing site Mendeley are known to be valuable for early research evaluation. They have strong correlations with citation counts for journal articles but appear about a year before them. There are disciplinary differences in the value of Mendeley reader counts but systematic evidence is needed at the level of narrow fields to reveal its extent. In response, this article compares Mendeley reader counts with Scopus citation counts for journal articles from 2012 in 325 narrow Scopus fields. Despite strong positive correlations in most fields, averaging 0.671, the correlations in some fields are as weak as 0.255. Technical reasons explain most weaker correlations, suggesting that the underlying relationship is almost always strong. The exceptions are caused by unusually high educational or professional use or topics of interest within countries that avoid Mendeley. The findings suggest that if care is taken then Mendeley reader counts can be used for early citation impact evidence in almost all fields and for related impact in some of the remainder. As an additional application of the results, cross-checking with Mendeley data can be used to identify indexing anomalies in citation databases
A molecular overlayer with the Fibonacci square grid structure
Quasicrystals differ from conventional crystals and amorphous materials in that they possess long-range order without periodicity. They exhibit orders of rotational symmetry which are forbidden in periodic crystals, such as five-, ten-, and twelve-fold, and their structures can be described with complex aperiodic tilings such as Penrose tilings and Stampfli-Gaehler tilings. Previous theoretical work explored the structure and properties of a hypothetical four-fold symmetric quasicrystal-the so-called Fibonacci square grid. Here, we show an experimental realisation of the Fibonacci square grid structure in a molecular overlayer. Scanning tunnelling microscopy reveals that fullerenes (C ) deposited on the two-fold surface of an icosahedral Al-Pd-Mn quasicrystal selectively adsorb atop Mn atoms, forming a Fibonacci square grid. The site-specific adsorption behaviour offers the potential to generate relatively simple quasicrystalline overlayer structures with tunable physical properties and demonstrates the use of molecules as a surface chemical probe to identify atomic species on similar metallic alloy surfaces
Delocalization transition of a disordered axion insulator
The axion insulator is a higher-order topological insulator protected by inversion symmetry. We show that, under quenched disorder respecting inversion symmetry on average, the topology of the axion insulator stays robust, and an intermediate metallic phase in which states are delocalized is unavoidable at the transition from an axion insulator to a trivial insulator. We derive this conclusion from general arguments, from classical percolation theory, and from the numerical study of a 3D quantum network model simulating a disordered axion insulator through a layer construction. We find the localization length critical exponent near the delocalization transition to be ν=1.42±0.12. We further show that this delocalization transition is stable even to weak breaking of the average inversion symmetry, up to a critical strength. We also quantitatively map our quantum network model to an effective Hamiltonian and we find its low-energy k⋅p expansion
Differences between journals and years in the proportions of students, researchers and faculty registering Mendeley articles
This article contains two investigations into Mendeley reader counts with the same dataset. Mendeley reader counts provide evidence of early scholarly impact for journal articles, but reflect the reading of a relatively young subset of all researchers. To investigate whether this age bias is constant or varies by narrow field and publication year, this article compares the proportions of student, researcher and faculty readers for articles published 1996-2016 in 36 large monodisciplinary journals. In these journals, undergraduates recorded the newest research and faculty the oldest, with large differences between journals. The existence of substantial differences in the composition of readers between related fields points to the need for caution when using Mendeley readers as substitutes for citations for broad fields. The second investigation shows, with the same data, that there are substantial differences between narrow fields in the time taken for Scopus citations to be as numerous as Mendeley readers. Thus, even narrow field differences can impact on the relative value of Mendeley compared to citation counts
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