Etiology of nocturia response in men with diminished bladder capacity

Aims: To test the hypothesis that patients with nocturia owing to diminished global or nocturnal bladder capacity improve via increased bladder capacity. Methods: This is a retrospective analysis of voiding diaries completed at a VA urology clinic between 2008-2017. Inclusion required patients aged at least 18 years, male, undergoing treatment for nocturia, and having completed at least two 24-hour voiding diaries >= 1 month apart. Patients were divided into two cohorts: responders (any decline in nocturia) and non-responders (no change or any increase in nocturia). Patients were further sub-stratified as having low global bladder capacity (maximum voided volume [MVV] = 200 mL). Wilcoxon rank-sum was applied with a Bonferroni correction to test significance. Results: Forty pre- and post-treatment diaries from 27 patients, and 19 pre- and post-treatment diaries from 17 patients were identified as having low global and low nocturnal bladder capacity, respectively. Nocturia responders with low global bladder capacity demonstrated significant decline compared to non-responders in nocturnal urine volume (NUV) (-140 vs +75, P < 0.01) and nocturnal bladder capacity index (NBCi) (-0.59 vs +0.23, P < 0.01). Patients with low nocturnal bladder capacity similarly demonstrated decreased NUV (-30 vs +160, P = 0.04) and NBCi (-1.4 vs +0.33, P < 0.01). There was no significant change in MVV or NMVV for either group. Conclusions: Treatment directed at lowering nocturnal urine production and enabling patients to consistently void at capacity is a rational strategy to treat nocturia in patients with low bladder capacity

Cidades Sob Clichê Imagético: Imaginação Espacial e Experimentações em Poesias Visuais

Esse trabalho procurou caracterizar o clichê imagético, articulando-o a exemplos relacionados às cidades provindas de pesquisas iconográficas realizadas no Google Imagens, dando-se, a partir desse contexto, se deram as rasuras dos clichês imagéticos por poesias visuais. A pesquisa iconográfica específica para a palavra cidades direcionou o estudo viabilizando a constatação deste clichê, que, por sua vez, foi enunciado como intermediador de imaginação espacial. As constatações empíricas sobre esta temática fez a pesquisa ser conduzida a cinco nomes de capitais brasileiras, que foram contrastadas com as imagens destas cidades caracterizadas fora do clichê imagético, sendo o formato padrão e estático da propagação das imagens foi o universo sobre o qual orbitou este estudo. Uma vez realizadas as observações sobre esta temática, passou-se à discussão poética referente às imagens captadas, e a partir de então foi feito um diálogo com artistas e poetas ao ponto de se delimitar uma justificativa para que poesias visuais fossem elaboradas rumando para outras grafias de mundo, passando, assim, a enfatizar novas possibilidades, para essas imagens identificadas como clichês. Então, este estudo visa possibilitar novas versões a serem produzidas sobre o mundo, optando pela temática cidade para melhor categorizar e referenciar a pesquisa iconográfica, direcionando a discussão acerca de espaços e paisagens urbanas. Para tanto, foram adotados os autores Deleuze e Guatarri, articulando seus diálogos com McLuhan e Watson, adentrando-se à dimensão do clichê e aparando-se na iconografia Google e na sua configuração repetida que então passa a evidenciar as características opostas das considerações elaboradas por Doreen Massey, para a imaginação espacial em seu processo fluídico, e não engessado. Pensando nas reverberações de dizeres que se contradizem dessas versões, a imaginação foi evidenciada para além desses processos, atentando-se, assim, às obras poéticas e artísticas de Manoel de Barros ou Valdelino Gonçalves, em que foram verificadas possibilidades de abertura de canais de diálogos com tais clichês, com poesias visuais, em um lançamento para a imaginação, rompendo-os. Em conclusão, foram observadas possibilidades de construções poéticas como dizeres de uma Geografia constituída no imaginário, mas que também possui suas significações perante a realidade, formuladas em rupturas com o dizer totalizante, repetido e homogêneo. Foram evidenciadas, então, essas características como contribuição aos estudos que tangem à temática Geografia e Imagens, possibilitando novas reverberações em universos de estudos para essa linha de pesquisa, que procura inovar nas percepções sobre o entendimento das imagens como canal de construção dos espaços geográficos de uma maneira geral. Palavras-Chave: Clichê imagético, Imaginação Espacial, Poética

Is there an association between aspects of the metabolic syndrome and overactive bladder?:A prospective cohort study in women with lower urinary tract symptoms

Objective: The aim of our study was to determine whether there is a link between aspects of the metabolic syndrome (MetS) and overactive bladder (OAB) in women with lower urinary tract symptoms (LUTS). Study design: A single-centre prospective study. We evaluated a cohort of consecutive women with LUTS attending a tertiary referral urodynamic clinic from October 2012 to January 2015. Obesity, diabetes, hypertension and dyslipidaemia were used as markers of MetS. OAB and detrusor overactivity (DO) were defined according to the International Urogynaecological Association/International Continence Society terminology. Results: Eight hundred and forty women were enrolled. Three hundred and eight (36.6%) had normal weight, 260 (31%) were overweight and 272 (32.4%) obese. We identified 168 women (20%) with hypertension, 64 (7.6%) with diabetes mellitus, and 98 (11.7%) with dyslipidaemia. Seven hundred and four (83.8%) women were diagnosed symptomatically with OAB and 305 (36.3%) were diagnosed urodynamically with DO. Obesity (p&lt;0.001) was the only independent predictor for OAB (OR 1.09, 95% CI 1.05-1.13) and DO (OR 1.06, 95% CI 1.03-1.08), respectively. Conclusion: Our study demonstrates a correlation between obesity and OAB/DO in female patients. However, other components of MetS do not appear to be associated with either OAB and DO. Weight reduction should be strongly recommended in women with OAB

Exigência de metionina +cistina total para codornas de corte de dois grupos genéticos

Four experiments were carried out in a completely randomized experimental design to evaluate the effect of total methionine + cystine on the performance and carcass traits of two European quail genetic strains EV1 (experiment 1and 2) and EV2 (experiment 3 and 4) during two phases of the growing period (from hatch to 21 days of age and from hatch to 35 days of age). The first experiment was evaluated in a completely randomized experimental design with six level of total methionine + cystine (.86; .96; 1.06; 1.16;1.26;1.36), four replicates and 15 quails per experimental unit. Body weight, weight gain, feed intake and feed: weight gain ratio were evaluated. Significant quadratic effects of total methionine + cystine level on the performance traits recorded from hatch to 21 days of age were observed. Highest body weight and weight gain were estimated for quails fed 1.21% total methionoine + cystine diets, lowest feed intake was estimated for quails fed 1.36% diets and best feed: weight gain ratio was estimated for quails fed 1.21% total methionoine + cystine diet. The second experiment a total of 288 quails of both sex were allotted in a completely randomized experimental design with six treatments and four replicates of 12 quails per experimental unit. The treatments consisted of six total metionine + cistine diet levels (0.72, 0.82, 0.92, 1,02, 1.12, and 1.22%). The evaluated performance traits were body weight, weight gain and feed: weight gain ratio and the carcass traits were body weight and weights and yields of carcass, breast, thigh, wings, edible giblets and fat pad. Significant quadratic effects of total methionine + cystine effect on all evaluated traits were observed. Maximum body weight and weight gains were estimated for quails fed 0.96% total methionine + cystine diets. A significant interaction between total methionine + cystine and sex for breast weight was observed Significant quadratic effect of total methionine + cystine were observed for body and carcass weights with estimated maximum for quails fed 0.97 and 0.99% total methionine + cystine diets, respectively. A decreasing linear effect of total methionine + cystine diet levels on thigh + drumstick, and an increasing effect on liver weight and yield were observed. Significant interaction effect between total methionine + cystine level and sex for carcass yield was observed. Body, liver and gizzard weights, and liver and gizzard yields were higher in the females. The total methionine + cystine requirement for weight gain from hatch to 21 days of age is 1.21% and the total methionine + cystine requirement for maximum body weight from 21 to 35 days of age is 0.95% and for carcass and breast weights is 0.95%. The third experiment was evaluated in a completely randomized experimental design with six level of total methionine + cystine (.86; .96; 1.06; 1.16; 1.26; 1.36), four replicates and 15 quails per experimental unit. Body weight, weight gain, feed intake and feed: weight gain ratio were evaluated. Significant and quadratic effects of total methionine + cystine on the performance traits recorded from hatch to 21 days of age were observed. Maximum weight and weight gain were estimated for quails fed 1.24% total methionine + cystine diets, 1.36% for lowest feed intake and 1.14% for best feed: weight gain ratio. Weight gain methioninine + cystine requirement from hatch to 21 days is 1.21% equivalent to a total methionine + cystine: lysine ratio equal to 0.71. The fourth experiment a total of 288 quails of both sex were allotted in a completely randomized experimental design with six treatments and four replicates of 12 quails per experimental unit. The treatments consisted of six total metionine + cistine diet levels (0.72, 0.82, 0.92, 1,02, 1.12, and 1.22%). The evaluated performance traits were body weight, weight gain and feed: weight gain ratio and the carcass traits were body weight and weights and yields of carcass, breast, thigh, wings, edible giblets and fat pad. Significant quadratic effects of total methionine + cystine on body weight and weight gain were observed. Maximum body weight and weight gains were estimated for quails fed 0.95 and 1.04% total methionine + cystine diets, respectively. Significant quadratic effect of total metionine + cystine on body and carcass weights were also observed with maximum values for quails fed 1.05% of total methionine + cystine diets. The females were heavier and showed higher liver and gizzard weights than the males. The total methionine + cystine requirement for maximum weight gain in the final phase of the growth period is 1.04 and for carcass and breast weights is 1.05%.Foram realizados quatro experimentosem delineamento inteiramente ao acaso para avaliar os efeitos dos níveis de metionina + cistina total sobre o desempenho e características de carcaça de dois grupos genéticos, EV1 (experimento I e II) e EV2 (experimento III e IV), de codornas de corte em crescimento (nascimento ao 21º e 22° ao 35° dia de idade). No primeiro experimento os tratamentos consistiram de seis níveis de metionina + cistina total (0,86; 0,96; 1,06; 1,16; 1,26 e 1,36), quatro repetições e 15 aves por unidade experimental. As características avaliadas foram o peso corporal, ganho de peso, consumo e conversão alimentar para fase inicial e na fase finalas características avaliadas foram peso corporal, ganho de peso e conversão alimentar para fase final e as de carcaças, o peso corporal, pesos e rendimentos de carcaça, peito, coxa, asas, vísceras comestíveis e gordura abdominal. No segundo experimento os tratamentos consistiram de dietas com seis níveis de metionina+ cistina total (0,72; 0,82; 0,92; 1,02; 1,12; 1,22%), quatro repetições e 12 codornas por unidade experimental. Na fase inicial observou-se efeito quadrático significativo do teor de metionina + cistina sobre todas as variáveis avaliadas do nascimento ao 21° dia de idade sendo observado melhor desempenho nas codornas alimentadas com 1,21% de metionina + cistina para peso corporal e ganho de peso, 1,36% de metionina+cistina para consumo e 1,1% de metionina+cistina para conversão alimentar. E na fase final as características de desempenho avaliadas foram o peso corporal, ganho de peso e conversão alimentar e as de carcaças, o peso corporal, pesos e rendimentos de carcaça, peito, coxa, asas, vísceras comestíveis e gordura abdominal. Observou-se efeito quadrático significativodo nível de metionina + cistina total sobre todas as variáveis avaliadas. Máximo peso corporal e ganho de peso foram estimados para codornas alimentadas com dietas contendo 0,95% de metionina + cistina total e melhor conversão alimentar com dietas com 0,96% de metionina +cistina total. Houve interação significativa entre o nível de metionina + cistina e o sexo para peso de peito. Houve efeito quadrático dos níveis de metionina+cistina total sobre o peso corporal e de carcaça, com pontos de máxima em 0,97 e 0,99%, respectivamente. Houve efeito linear decrescente do nível de metionina + cistina total sobre peso e rendimento da coxa+sobrecoxa e decrescente sobre o peso e rendimento do fígado. Observou-se interação significativa entre o nível de metionina+cistinae sexo para rendimento de carcaça.Os pesos corporal, do fígado, da moela e rendimentos de fígado e moela foram maiores nas fêmeas. A exigência de metionina + cistina para máximo ganho de peso na fase inicial é de 1,21% e aexigência de metionina + cistina para máximos ganho de peso na fase final e pesos de carcaça e peito é de 0,95% de metionina+cistina total. No terceiro experimento os tratamentos consistiram de seis níveis de metionina + cistina total (0,86; 0,96; 1,06; 1,16; 1,26 e 1,36), quatro repetições e 15 aves por unidade experimental na fase inicial e na fase final os tratamentos consistiram de dietas com seis níveis de metionina+ cistina total (0,72; 0,82; 0,92; 1,02; 1,12; 1,22%), quatro repetições e 12 codornas por unidade experimental. As características avaliadas foram o peso corporal, ganho de peso, consumo e conversão alimentar para fase inicial e na fase final as características avaliadas foram peso corporal, ganho de peso e conversão alimentar para fase final e as de carcaças, o peso corporal, pesos e rendimentos de carcaça, peito, coxa, asas, vísceras comestíveis e gordura abdominal. No III experimento observou-se efeito quadrático significativo do nível de metionina + cistina total sobre todas as características avaliadas do nascimento ao 21° dia de idade. Máximos peso corporal e ganho de peso foram estimados para codornas alimentadas com dietas contendo 1,24% de metionina + cistina total, 1,36% para menor consumo de dieta e 1,14% para menor conversão alimentar. A exigência de metionina + cistina para máximo ganho de peso na fase inicial é de 1,24%, correspondendo a um relação de metionina+cistina:lisina de 0,71. No quarto experimento observou-se efeito quadrático significativo dos níveis de metionina + cistina total sobre o peso corporal e ganho de peso do 22° ao 35° dia de idade. Estimaram-se máximos peso e ganhos de peso para codornas alimentadas com dietas contendo 0,95% e 1,04% de metionina + cistina total, respectivamente. Houve efeito quadrático dos níveis de metionina+cistina total sobre o peso corporal, carcaça, com o ponto de máxima para codornas alimentadas com dietas com 1,05% de metionina + cistina. Os pesos corporal, do fígado e da moela foram maiores nas fêmeas do que nos machos. A exigência de metionina + cistina para máximo ganho de peso na fase final é de 1,04%, e para pesos de carcaça e peito é de 1,05% de metionina+cistina total

IMPLEMENTATION OF SISPREÇO - PRICE SURVEY SYSTEM RECEIVED BY RURAL PRODUCERS FOR STRATEGIC DECISION-MAKING IN STATE OF ESPÍRITO SANTO, BRAZIL

Purpose: This article highlights the importance of implementation of the Price Survey System Received by Rural Producers (SisPreço) at the Capixaba Institute of Research, Technical Assistance and Rural Extension (Incaper). The system was developed between 2022 and 2023 and implemented between December 2023 and August 2024, with the aim of systematizing the collection and dissemination of price data for the main agricultural products produced in Espírito Santo and providing timely information for Strategic Decision-Making.   Framework: The literature review cited cases of other institutions that carry out price surveys similar to Incaper. However, the focus of the study was to present the case of Incaper.   Design/Methodology/Approach: The methodology used was exploratory in nature, through a case study of the implementation of SisPreço at Incaper.   Conclusions: SisPreço is currently used to launch price quotations in 70 municipalities in the State and has proven to be an essential tool for professionals in the agricultural sector who wish to speed up the process of obtaining accurate information on the prices of agricultural products, as well as analyzing market trends. The use of the system allowed greater survey precision and price dissemination.   Research, Practical &amp; Social Implication: Price surveys are widely used as a reference for strategic decisions in various sectors of the economy and society, in addition to more precisely contributing to the planning of public policies and market analyses.   Originality/Value: Data systematization through SisPreço opens up new possibilities for advanced analysis, such as predictive modeling and integration with other agricultural databases, expanding the impact of price survey for government and business decision-making in agribusiness

Implantação de Unidade Psiquiátrica livre de tabaco em um hospital geral

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Determination of left atrial volume in healthy dogs and dogs with myxomatous mitral valve disease

Abstract: The left atrial volume (LAV) can be obtained using the biplane Simpson's method via echocardiography. Although in medicine this parameter has been considered to be a prognostic marker of left atrial enlargement in several cardiac diseases, in dogs with myxomatous mitral valve degeneration (MMVD), a valvulopathy characterized by left atrial (LA) volume overload, atrial enlargement is usually assessed by the LA-to-Aorta ratio (LA:Ao). Therefore, the body surface area (BSA)-indexed LAV was measured in healthy dogs and in dogs with MMVD using the biplane Simpson's method. For this purpose, a total of 107 healthy dogs (control) and 81 dogs with MMVD in ACVIM stages B1, B2 and C were assessed, with LAV being calculated during atrial diastole (d) and systole (s) through the biplane Simpson's method. Two-dimensional apical four-chamber (4C) and two-chamber (2C) images were obtained in every dog through the left parasternal window. The values obtained from healthy dogs were correlated with body weight using Pearson's test. An analysis of variance (ANOVA) and Tukey's test were used to compare healthy and MMVD dogs, as well as to investigate differences according with MMVD stages. A strong positive correlation was documented between either LAVd (r> 0.77) or LAVs (r> 0.73) and body weight in healthy dogs. The BSA-indexed LAV calculated for MMVD dogs was significantly different (p<0.01) from that obtained for the control group. Also, LAV was significantly different (P<0.05) when stages B2 and C, and B1 and C were compared. In conclusion, this study provided a reference for left atrial volume and the applicability of this technique to assess atrial overload in dogs with varying-stage MMVD

Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of epsilon-poly-L-lysine capped mesoporous silica-based nanoparticles

[EN] Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. By incorporating recently described TCS histidine kinase autophosphorylation inhibitors (HKAIs) into epsilon-poly-L-lysine capped nanoparticles (NPs) we could overcome the Gram negative (Gr(-)) permeability barrier for the HKAIs. The observed bactericidal activity against Gr(-) bacteria was shown to be due to the enhanced delivery and internalization of the HKAIs and not an inhibitory or synergistic effect of the NPs. The NPs had no adverse effects on mammalian cell viability or the immune function of macrophages in vitro and showed no signs of toxicity to zebrafish larvae in vivo. These results show that HKAIs are promising antibacterials for both Gr(-) and Gr + pathogens and that NPs are a safe drug delivery technology that can enhance the selectivity and efficacy of HKAIs against bacteria. (C) 2016 Elsevier Inc. All rights reserved.This work was funded by FP7 ITN STARS-Scientific Training in Antimicrobial Research Strategies (Contract No. PITN-GA-2009-238490, J.M.W., A.M.), H2020 MSCA IF (AND-659121, N.V.), grant BIO2013-42619-P from the Ministerio de Economia y Competitividad (A.M.), grant from the Spanish Government (Project MAT2015-64139-C4-1-R,N. M., J.R.M, R.M.M.), and a grant from Generalitat Valenciana (Project PROMETEOII/2014/047, N.M.). and Prometeo II/2014/029, A.M.).Velikova, N.; Mas Font, N.; Miguel-Romero, L.; Polo, L.; Stolte, E.; Zaccaria, E.; Cao, R.... (2017). Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of epsilon-poly-L-lysine capped mesoporous silica-based nanoparticles. Nanomedicine Nanotechnology Biology and Medicine. 13(2):569-581. https://doi.org/10.1016/j.nano.2016.09.011S56958113