The Hidden Curriculum in Technology Business Based Incubators

[Resumo] O fenómeno do emprendedorismo transformou o mundo en todos os sectores, e especialmente nos ambientes proxectados para acomodar as empresas que buscan a modernización e a transformación de ideas en produtos, procesos ou servizos, como é o caso das incubadoras. Este artigo ten como obxectivo identificar o currículo oculto en empresas de base tecnolóxica incubadas. Trátase dunha pescuda exploratorio-cualitativa, pois non hai coñecemento estruturado sobre o currículo oculto en incubadoras de empresas. As metodoloxías utilizadas foron a entrevista semiestruturada e as observacións. A pescuda realizouse no Centro de Desenvolvemento Tecnolóxico da Universidade de Brasilia (Brasil), en empresas incubadas, buscando integrar os factores internos e externos, as actitudes, os valores, os comportamentos e as orientacións sobre a aprendizaxe dentro dunha incubadora de empresas. Así, propoñemos un modelo de identificación de currículo oculto (MIC) na incubadora para comprobar a relación entre o suxeito e o ambiente. Tal modelo mostra os factores internos e externos indutores do currículo oculto na aprendizaxe. A pescuda permitirá contribuír a que os xestores de incubadoras melloren aínda máis a formación dos emprendedores desde a perspectiva do currículo oculto, co fin de maximizar o coñecemento innovador. Esta pescuda sobre o currículo oculto nunha incubadora de empresas de tecnoloxía, inédita no medio académico, ten como obxectivo propor un modelo para a identificación do currículo oculto.[Abstract] The phenomenon of entrepreneurship has transformed the world in all sectors, especially in environments designed to accommodate companies seeking modernization and transformation of ideas into products, processes and / or services, as in the case of the incubators. The article aims to identify the hidden curriculum in technology-based companies incubated. This is an exploratory research - qualitative, because there is no structured knowledge about the hidden curriculum in business incubators. The method was semi-structured interviews and observations. The research was conducted at the Centre of Technological Development at the University of Brasilia (Brazil), incubated companies seeking to integrate the internal and external factors which are the attitudes, values, behaviours and guidance on learning within a Business Incubator. Thus, we propose a Model Identification of hidden curriculum in the Incubator (MIC) to prove the relationship between the subject and the environment. The model shows the internal and external factors as the inducer of the hidden curriculum in learning. The research will allow a contribution to the incubator managers that will further improve the training of entrepreneurs from the perspective of the hidden curriculum to maximize innovative knowledge. The research is unprecedented in academia about the hidden curriculum in a Technology Business Incubator, aiming to propose a model for identifying hidden curriculum

Deamidation of Proteins: The crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67

The non-enzymatic deamidation of asparagine residues in proteins is a widely occurring reaction, both in vivo and in vitro. Although the importance of this process is commonly recognised, only little structural information is available on it. In order to evaluate the structural effects of this reaction in proteins, we have determined the crystal structure of a ribonuclease A derivative in which asparagine 67 has been replaced by an isoaspartyl residue, as a consequence of an in vitro deamidation reaction. The overall structure of the model, refined to a crystallographic R-factor of 0.159 at a resolution of 1.9 Å, is very similar to that of the native protein, but considerable deviations are observed in the region delimited by the disulphide bridge 65–72. In particular, the insertion of an extra methylene group in the main chain at residue 67 breaks up the hydrogen bond network that makes this region rather rigid in ribonuclease A. On the basis of the structure observed, some of the slightly but significantly different properties of this deamidated derivative, with respect to the native enzyme, can be explained

In HspA from Helicobacter pylori vicinal disulfide bridges are a key determinant of domain B structure

Helicobacter pylori produces a heat shock protein A (HspA) that is unique to this bacteria. While the first 91 residues (domain A) of the protein are similar to GroES, the last 26 (domain B) are unique to HspA. Domain B contains eight histidines and four cysteines and was suggested to bind nickel. We have produced HspA and two mutants: Cys94Ala and Cys94Ala/Cys111Ala and identified the disulfide bridge pattern of the protein. We found that the cysteines are engaged in three disulfide bonds: Cys51/Cys53, Cys94/Cys111 and Cys95/Cys112 that result in a unique closed loop structure for the domain

Reducing Healthcare Costs in New York with Syringe Exchange Program Implementation

This paper explores the cost-effectiveness of New York State-approved syringe exchange programs (SEPs), and provides an estimate of the annual savings in healthcare costs due to these programs. The research utilizes the simplified circulation model that estimated cost savings in Laufer’s (2001) study, however with the most recent data. The cost-effectiveness analysis used data provided by seventeen SEPs, as well as published data for the most recent 12-month period available, and treatment costs from the literature. An estimated 1,608 human immunodeficiency virus (HIV) cases are averted annually in the injection drug user (IDU) population, which translates to about $51,754,152 in treatment cost savings each year due to syringe exchange programs in New York. This research further demonstrates the cost-effectiveness of syringe exchange as prevention strategy.SUNY BrockportPublic Health and Health EducationSenior Honors These

Reducing Healthcare Costs in New York with Syringe Exchange Program Implementation

This paper explores the cost-effectiveness of New York State-approved syringe exchange programs (SEPs), and provides an estimate of the annual savings in healthcare costs due to these programs. The research utilizes the simplified circulation model that estimated cost savings in Laufer’s (2001) study, however with the most recent data. The cost-effectiveness analysis used data provided by seventeen SEPs, as well as published data for the most recent 12-month period available, and treatment costs from the literature. An estimated 1,608 human immunodeficiency virus (HIV) cases are averted annually in the injection drug user (IDU) population, which translates to about $51,754,152 in treatment cost savings each year due to syringe exchange programs in New York. This research further demonstrates the cost-effectiveness of syringe exchange as prevention strategy

Euripides’ Hippolytos in Aristophanes: Eὐριπιδαριστοφανίζειν through Ἱππολυτίζειν

Aristophanes’ paratragic and parodic relationship with Euripides has long been discussed in classical scholarship mainly due to the numerous references to Euripides and his tragedies in Aristophanes’ comedies. This article focuses on the use and re-use of the myth of Hippolytos in Aristophanes, as it is found in Euripides’ extant play. The references to Hippolytos found in Aristophanes’ extant and fragmentary plays will be discussed. One of the main purposes of this paper is to bring into attention not only the references to Euripides’ Hippolytus in the extant plays but also in the fragments, which have been rather interesting in terms of their scale and nature as they are very different to the ones found in the extant plays, where the focus of the parody is mainly the character of Phaidra. Aristophanes is donning Euripides’ costumes to serve his purposes and scenarios. The present essay navigates through how Aristophanes used the same Euripidean disguise not just to εὐριπιδαριστοφανίζειν but specifically to ἱππολυτίζειν within his oeuvre

Molecular characterization of two chloroplast biogenesis regulators in Arabidopsis thaliana

Plastid ribosomes are derived from ancestral endosymbiontic cyanobacteria and are composed of a large (50S) and a small (30S) subunit. Each subunit contains ribosomal proteins and ribosomal RNAs. The majority of these ribosomal proteins are also involved with ribosome biogenesis and functioning and are encoded in the nucleus. However only a small percentage of ribosomal proteins are chloroplast encoded. The first part of this doctoral thesis reports the identification and characterization of the Arabidopsis thaliana nuclear encoded CHLOROPLAST RIBOSOME ASSOCIATED (CRASS) protein. This protein has emerged during embryophyta evolution and resides in the chloroplast stroma of land plants but not in green algae or cyanobacteria. Under optimal growth conditions CRASS is not required for plant survival and crass mutants show minor defects in photosynthesis and plant fitness. On the other hand, translation inhibitors (lincomycin and chloramphenicol) and cold stress exacerbate the mutant plant phenotype. In co-immuno-precipitation experiments, CRASS is pulled down with 16S RNA and with the small ribosomal subunits PRPS1 and PRPS5. CRASS interacts with ribosomal proteins independently of ribosomal RNAs, suggesting a protein-protein interaction with other subunits or structural components of the ribosome. Double mutants have a synergistic mutant phenotype confirming that CRASS plays a role in the stability of the chloroplast and becomes crucial when stress conditions interfere with ribosome biogenesis and activity. An additional crucial role in the development of the chloroplasts is played by the assembly factors which allow correct formation of thylakoid membrane complexes needed to sustain phototrophic growth. The second part of this dissertation focuses on a DNAJ related protein, SNOWY COTYLEDON2 (SCO2), required for thylakoid complex assembly and protein interaction with the light-harvesting chlorophyll-binding protein LHCB1. Its role in chloroplast biogenesis in true leaves of Arabidopsis thaliana and Lotus japonicus, previously thought to be a protein acting exclusively in cotyledon greening, is here analysed. The lack of SCO2 in Arabidopsis results in a drastic decrease in plant growth and photosynthesis efficiency under short-day conditions, while SCO2 disruption in Lotus induces white and green variegated leaves and stunted growth. In this case, inhibition of translation rates does not decrease the variegation phenotype as in other variegated mutants. Furthermore, in Arabidopsis, the combined absence of SCO2 and ClpR1 causes a severe variegated phenotype. These effects suggest that SCO2 can be considered a new component able to suppress leaf variegation. Taken together, the results of this thesis highlight the possibility to discover new gene functions, such as CRASS and SCO2. These genes have been functionally characterized by inducing stresses that enhanced otherwise undetected phenotypes

Pensamiento. Papeles de filosofía 4

Pensamiento. Papeles de filosofía pretende ser una mirada filosófica sagaz y profunda sobre la realidad. Es un ojo audaz que mira más allá de “lo que aparece” para adentrarse en las entrañas del ser del hombre y su circunstancia. Es un ver la vida, lo que nos rodea con detenimiento, tratando de responder a las preguntas esenciales que nos afectan directamente: ¿qué es el hombre?, ¿cuál es su realidad?, ¿a dónde se dirige?, ¿cuál es su finalidad en el mundo?, ¿qué sentido tiene la vida?, entre muchas otras cuestiones que nos mueven a reflexionar

Interfacing an 8085-Based Microcontroller: A Practical Approach to Developing Computer Applications Skills

In the Electronics Technology course – EE 445, students were directed to construct, troubleshoot, and interface an 8085-based microcontroller in order to control electromechanical circuits. This microprocessor, using Intel 8085A processor, was assembled from components and was interfaced to take full control of a stepper motor’s motion. In addition, the microprocessor’s application to generate and measure waveforms was examined. This manuscript attempts to describe the basic architecture of a microcontroller system, and examine its interfacing techniques as well as its applications in providing communication to the outside world