Gaia view of low-mass star formation

Understanding how young stars and their circumstellar disks form and evolve is key to explain how planets form. The evolution of the star and the disk is regulated by different processes, both internal to the system or related to their environment. The former include accretion of material onto the central star, wind emission, and photoevaporation of the disk due to high-energy radiation from the central star. These are best studied spectroscopically, and the distance to the star is a key parameter in all these studies. Here we present new estimates of the distance to a complex of nearby star-forming clouds obtained combining TGAS distances with measurement of extinction on the line of sight. Furthermore, we show how we plan to study the effects of the environment on the evolution of disks with Gaia, using a kinematic modelling code we have developed to model young star-forming regions.Comment: 4 pages, 1 figure. To appear in the Proceedings of IAU Symposium 330: Astrometry and Astrophysics in the Gaia Sk

Electrochemical Biofunctionalization of Highly Oriented Pyrolytic Graphite for Immunosensor Applications

The present research demonstrates a procedure for surface modification of Highly Oriented Pyrolytic Graphite (HOPG) electrodes intended for use as immunosensors. The HOPG surface is linked to the molecule 8-hydroxydeoxyguanosine (8-OHdG), an oxidative stress biomarker for DNA damage, though the aniline mediator covalently bonded to electrode and biomarker. An electrochemical procedure to graft the mediator is described and the presence of biomarker at surface is demonstrated by using a fluorescence-labeled immune-reagent. An electrochemical functionalization process has been employed for attachment of functional aminie (NH2) linking groups to graphitic surfaces, which consists of two stages: (i) a reaction with a diazonium salt to covalently bond nitrobenzene groups to the surface and (ii) electrochemical reduction of the nitro group (–NO2) to an amine group (–NH2). The shape of the CV curve indicates that the redox reactions are taking place at the HOPG electrode surface. The amine group can subsequently be used to covalently link to an antibody biorecptor. The presence of 8-OHdG, indicative of DNA damage, has been linked to increased cancer risk. Detection of this oxidative stress biomarker is an important tool for the early diagnosis of disease

3D mapping of young stars in the solar neighbourhood with Gaia DR2

We study the three dimensional arrangement of young stars in the solar neighbourhood using the second release of the Gaia mission (Gaia DR2) and we provide a new, original view of the spatial configuration of the star forming regions within 500 pc from the Sun. By smoothing the star distribution through a gaussian filter, we construct three dimensional density maps for early-type stars (upper-main sequence, UMS) and pre-main sequence (PMS) sources. The PMS and the UMS samples are selected through a combination of photometric and astrometric criteria. A side product of the analysis is a three dimensional, G-band extinction map, which we use to correct our colour-magnitude diagram for extinction and reddening. Both density maps show three prominent structures, Scorpius-Centaurus, Orion, and Vela. The PMS map shows a plethora of lower mass star forming regions, such as Taurus, Perseus, Cepheus, Cassiopeia, and Lacerta, which are less visible in the UMS map, due to the lack of large numbers of bright, early-type stars. We report the finding of a candidate new open cluster towards $l, b \sim 218.5^{\circ}, -2^{\circ}$, which could be related to the Orion star forming complex. We estimate ages for the PMS sample and we study the distribution of PMS stars as a function of their age. We find that younger stars cluster in dense, compact clumps, and are surrounded by older sources, whose distribution is instead more diffuse. The youngest groups that we find are mainly located in Scorpius-Centaurus, Orion, Vela, and Taurus. Cepheus, Cassiopeia, and Lacerta are instead more evolved and less numerous. Finally, we find that the three dimensional density maps show no evidence for the existence of the ring-like structure which is usually referred to as the Gould Belt.Comment: 17 pages, 17 figures, 6 appendixes; accepted for publication in A&A; image quality decreased to comply with the arXiv.org rules on file siz

Mapping young stellar populations towards Orion with Gaia DR1

We use the first data release of the Gaia mission to explore the three dimensional arrangement and the age ordering of the many stellar groups towards the Orion OB association, aiming at a new classification and characterization of the stellar population. We make use of the parallaxes and proper motions provided in the Tycho Gaia Astrometric Solution (TGAS) sub-set of the Gaia catalogue, and of the combination of Gaia and 2MASS photometry. In TGAS we find evidence for the presence of a young population, at a parallax $\varpi \sim 2.65 \, \mathrm{mas}$, loosely distributed around some known clusters: 25 Ori, $\epsilon$ Ori and $\sigma$ Ori, and NGC 1980 ($\iota$ Ori). The low mass counterpart of this population is visible in the color-magnitude diagrams constructed by combining Gaia and 2MASS photometry. We study the density distribution of the young sources in the sky. We find the same groups as in TGAS, and also some other density enhancements that might be related to the recently discovered Orion X group, the Orion dust ring, and to the $\lambda$ Ori complex. We estimate the ages of this population and we infer the presence of an age gradient going from 25 Ori (13-15 Myr) to the ONC (1-2 Myr). We confirm this age ordering by repeating the Bayesian fit using the Pan-STARRS1 data. The estimated ages towards the NGC 1980 cluster span a broad range of values. This can either be due to the presence of two populations coming from two different episodes of star formation or to a large spread along the line of sight of the same population. Our results form the first step towards using the Gaia data to unravel the complex star formation history of the Orion region in terms of the different star formation episodes, their duration, and their effects on the surrounding interstellar medium.Comment: 17 pages, 17 figure

Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker

A generic electrochemical method of 'bioreceptor' antibody attachment to phenyl amine functionalized graphitic surfaces is demonstrated. Micro-channels of chemically modified multi-layer epitaxial graphene (MLEG) have been used to provide a repeatable and reliable response to nano-molar (nM) concentrations of the cancer risk (oxidative stress) biomarker 8-hydroxydeoxyguanosine (8-OHdG). X-ray photoelectron spectroscopy, Raman spectroscopy are used to characterize the functionalized MLEG. Confocal fluorescence microscopy using fluorescent-labelled antibodies indicates that the anti-8-OHdG antibody selectively binds to the phenyl amine-functionalized MLEG's channel. Current–voltage measurements on functionalized channels showed repeatable current responses from antibody–biomarker binding events. This technique is scalable, reliable, and capable of providing a rapid, quantitative, label-free assessment of biomarkers at nano-molar (<20 nM) concentrations in analyte solutions. The sensitivity of the sensor device was investigated using varying concentrations of 8-OHdG, with changes in the sensor's channel resistance observed upon exposure to 8-OHdG. Detection of 8-OHdG concentrations as low as 0.1 ng ml−1 (0.35 nM) has been demonstrated. This is five times more sensitive than reported enzyme linked immunosorbent assay tests (0.5 ng ml−1)

Serologic evidence of pertussis infection in vaccinated Iranian children

Background: It seems that the incidence of pertussis-like illnesses is considerably increasing despite the wide coverage of immunization with the whole cell pertussis vaccine. We aimed to investigate the occurrence of pertussis in vaccinated children by measuring anti-pertussis antibodies. Methods: In this cross-sectional study, blood samples were taken from vaccinated children aged 2, 4, 6, 12, 18, and 72 months. Anti-pertussis IgG and IgA were measured by ELISA. P<0.05 was considered significant. Results: 725 children were enrolled in the study. Geometric mean titers for IgG that showed a slight decease after 2 months of age and increased distinctly in children aged 72 months. The frequency of the individuals whose IgG was above the determined cut-off (derived from mean+2SD) was observed in 1 of the 2, 4, and 6-month-old infants, 6 of the 12 and 18-month-olds and 12 of the 6-year -old children. Positive IgA titers were detected in 5, 9, 6, 23, 11, and 8 of children aged 2, 4, 6, 12, 18, and 72 months, respectively. Conclusion: Since a considerable percentage of children had high levels of anti-pertussis IgG antibodies (≥2 SD), positive anti-pertussis IgA, and most importantly an increased level of anti-pertussis IgG geometric mean titer at 6 years of age, further investigations regarding the protection provided by the presently used pertussis vaccine seems necessary

Mesozoic–Tertiary exhumation history of the Altai Mountains, northern Xinjiang, China: New constraints from apatite fission track data

This study uses apatite fission track (FT) analysis to constrain the exhumation history of bedrock samples collected from the Altai Mountains in northern Xinjiang, China. Samples were collected as transects across the main structures related to Palaeozoic crustal accretion events. FT results and modeling identify three stages in sample cooling history spanning the Mesozoic and Tertiary. Stage one records rapid cooling to the low temperature part of the fission track partial annealing zone circa 70 ± 10 °C. Stage two, records a period of relative stability with little if any cooling taking place between 75 and 25–20 Ma suggesting the Altai region had been reduced to an area of low relief. Support for this can be found in the adjacent Junngar Basin that received little if any sediment during this interval. Final stage cooling took place in the Miocene at an accelerated rate bringing the sampled rocks to the Earth's surface. This last stage, linked to the far field effects of the Himalayan collision, most likely generated the surface uplift and relief that define the present-day Altai Mountains