New Constraints on the Escape of Ionizing Photons From Starburst Galaxies Using Ionization-Parameter Mapping

The fate of ionizing radiation in starburst galaxies is key to understanding cosmic reionization. However, the galactic parameters on which the escape fraction of ionizing radiation depend are not well understood. Ionization-parameter mapping provides a simple, yet effective, way to study the radiative transfer in starburst galaxies. We obtain emission-line ratio maps of [SIII]/[SII] for six, nearby, dwarf starbursts: NGC 178, NGC 1482, NGC 1705, NGC 3125, NGC 7126, and He 2-10. The narrow-band images are obtained with the Maryland-Magellan Tunable Filter at Las Campanas Observatory. Using these data, we previously reported the discovery of an optically thin ionization cone in NGC 5253, and here we also discover a similar ionization cone in NGC 3125. This latter cone has an opening angle of 40+/-5 degrees (0.4 ster), indicating that the passageways through which ionizing radiation may travel correspond to a small solid angle. Additionally, there are three sample galaxies that have winds and/or superbubble activity, which should be conducive to escaping radiation, yet they are optically thick. These results support the scenario that an orientation bias limits our ability to directly detect escaping Lyman continuum in many starburst galaxies. A comparison of the star-formation properties and histories of the optically thin and thick galaxies is consistent with the model that high escape fractions are limited to galaxies that are old enough (> 3 Myr) for mechanical feedback to have cleared optically thin passageways in the ISM, but young enough (< 5 Myr) that the ionizing stars are still present.Comment: Accepted for publication in Ap

An Ionization Cone in the Dwarf Starburst Galaxy NGC 5253

There are few observational constraints on how the escape of ionizing photons from starburst galaxies depends on galactic parameters. Here, we report on the first major detection of an ionization cone in NGC 5253, a nearby starburst galaxy. This high-excitation feature is identified by mapping the emission-line ratios in the galaxy using [S III] lambda 9069, [S II] lambda 6716, and H_alpha narrow-band images from the Maryland-Magellan Tunable Filter at Las Campanas Observatory. The ionization cone appears optically thin, which is suggestive of the escape of ionizing photons. The cone morphology is narrow with an estimated solid angle covering just 3% of 4pi steradians, and the young, massive clusters of the nuclear starburst can easily generate the radiation required to ionize the cone. Although less likely, we cannot rule out the possibility of an obscured AGN source. An echelle spectrum along the minor axis shows complex kinematics that are consistent with outflow activity. The narrow morphology of the ionization cone supports the scenario that an orientation bias contributes to the difficulty in detecting Lyman continuum emission from starbursts and Lyman break galaxies.Comment: 5 pages, 4 figures, Accepted to ApJ Letter

The fundamental groups of subsets of closed surfaces inject into their first shape groups

We show that for every subset X of a closed surface M^2 and every basepoint x_0, the natural homomorphism from the fundamental group to the first shape homotopy group, is injective. In particular, if X is a proper compact subset of M^2, then pi_1(X,x_0) is isomorphic to a subgroup of the limit of an inverse sequence of finitely generated free groups; it is therefore locally free, fully residually free and residually finite.Comment: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol5/agt-5-67.abs.htm

Functional selectivity of GPCR-directed drug action through location bias.

G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes. We show here that the homologous human β 1 -adrenergic receptor initiates an internal G s -cAMP signal from the Golgi apparatus. By developing a chemical method to acutely squelch G-protein coupling at defined membrane locations, we demonstrate that Golgi activation contributes significantly to the overall cellular cAMP response. Golgi signaling utilizes a preexisting receptor pool rather than receptors delivered from the cell surface, requiring separate access of extracellular ligands. Epinephrine, a hydrophilic endogenous ligand, accesses the Golgi-localized receptor pool by facilitated transport requiring the organic cation transporter 3 (OCT3), whereas drugs can access the Golgi pool by passive diffusion according to hydrophobicity. We demonstrate marked differences, among both agonist and antagonist drugs, in Golgi-localized receptor access and show that β-blocker drugs currently used in the clinic differ markedly in ability to antagonize the Golgi signal. We propose \u27location bias\u27 as a new principle for achieving functional selectivity of GPCR-directed drug action

On Snake cones, Alternating cones and related constructions

We show that the Snake on a square $SC(S^1)$ is homotopy equivalent to the space $AC(S^1)$ which was investigated in the previous work by Eda, Karimov and Repov\vs. We also introduce related constructions $CSC(-)$ and $CAC(-)$ and investigate homotopical differences between these four constructions. Finally, we explicitly describe the second homology group of the Hawaiian tori wedge