GENETIC MARKERS OF AUTISM

Autism is a complex neurodevelopmental disorder with a significant genetic component. The prevalence of autism has been increasing globally, though exact statistics for India are not available. Several genetic markers for autism have been studied. These include chromosomal abnormalities, copy number variations, submicroscopic cytogenetic anomalies, single nucleotide polymorphisms and other point mutations. This review gives details on the current data available on these genetic markers of autism, with a focus on single nucleotide polymorphisms. Studies on SNPs within candidate genes on each chromosome are dealt with, including some details on which populations show which variation. Methodology involved in analysis of SNPs, i.e. techniques in SNP genotyping are also reviewed, focusing on those techniques that are simple and economically feasible in the Indian scenario

Characterization and Compositional Analysis of Indian Black Aggregate as a Concrete Raw Material

The study is conducted to find the applicability of Indian black aggregate as a concrete material through a series of physiochemical and surface morphological investigation. The report reveals the effects of different chemical properties on concrete performance which ultimately affect life period of any structure. Mineralogical and Chemical characterization of the aggregate was analysed by UV visible spectroscopy (UV-vis), X-Ray Fluorescence (ED-XRF) and X-Ray Diffraction (XRD). Scanning electron microscopy (SEM) used to know Surface morphology of the aggregate. It was observed that studied aggregate contains high amount of MgO (4.36%) and Fe2O3 (14.84%). However, it is quite stable up to 800 oC with loss of only 1.58% of gross weight. The surface morphology analysis clearly revealed the existence of Calcite, Quartz and Dolomite materials in studied aggregate

Separation of Acetic Acid from Aqueous Solution using Various Organic Solvents

In the study a model has been developed to separate the acetic acid from aqueous solution by liquid-liquid extraction and find out the proper solvent for this separation. Various solvents such as n-butanol, iso butanol, amyl alcohol and ethyl acetate are used for separation of acetic acid from water. The binodal curves (mutual solubility curves) for acetic acid distributed between water and an organic solvent were obtained by titrating known mixtures of two components (water and solvents) with the third component acetic acid to the point of first appearance of permanent turbidity. In order to determine the tie-lines, the absorbance of the coexisting phases, obtained by the separation of ternary mixtures within the binodal curve are needed to be determined. The absorbance of each point had been determined by a UV spectrophotometer. Distribution diagrams are obtained by plotting weight percent of acetic acid in solvent phase against the weight percent of acetic acid in water phase. Selectivity diagrams are also obtained by plotting (wt. % of acetic acid) / (percent of acetic acid + percent of water) in solvent phase against the same quantity in the diluent phase. The separation factor is determined numerically from the tie-line data

One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice

宮崎大学博士(医学)2015年度doctoral thesi

The Images of White Womanhood in Incidents in the Life of a Slave Girl

Black women’s literature especially, slave narratives, are generally considered as a resistance against the white male hegemony. But, if we go deep into it we notice, woven in the intricate weave of the narrative, the stories of the white women as well. Complex relationships between black and white women and between white men and white women are depicted in these records of American history. The present paper is an analysis the relationship of the white women to their circumstances as depicted in Incidents in the Life of a Slave Girl by Harriet Jacobs. Incidents is a compelling true story about the physical and psychological oppression of the black slave women in the south but it is also a story that breaks many a myth about the southern white women as well. Key words: Slave Narrative; Black American Literature; Slavery; Cult of True Womanhood; Oppression; Racism; White Male Hegemony; Deep Sout

Testicular Dysfunction Via Uvb-Induced Hyperthyroidism And Prophylactic Glycyrrhizin Dose In Swiss Albino Mice

This study explores the protective potential of glycyrrhizin, a compound from licorice root, against UVB-induced testicular dysfunction. UVB exposure disrupts hormonal balance, potentially leading to impaired male fertility. Glycyrrhizin\u27s established antioxidant and anti-inflammatory properties suggest its efficacy in mitigating these detrimental effects. A rodent model will be employed, with controlled UVB irradiation mimicking hyperthyroidism-induced testicular damage. Testicular function will be assessed via sperm quality and motility. Additionally, oxidative stress markers (malondialdehyde) and antioxidant enzyme activity (SOD, CAT, GSH) will be evaluated. Histological examination will reveal potential alterations in spermatogenesis and seminiferous tubule structure. A crucial aspect involves administering glycyrrhizin to a designated UVB-exposed group. Comparing parameters between control, UVB-exposed, and glycyrrhizin-treated groups will elucidate its potential to reduce oxidative stress and preserve testicular health. This research aims to shed light on glycyrrhizin\u27s protective role against UVB-induced testicular toxicity. By evaluating its efficacy in mitigating oxidative damage and preserving testicular function, this study can contribute valuable insights for developing therapeutic strategies to safeguard male reproductive health following UVB exposure. The findings may hold particular relevance for individuals with high occupational UVB exposure or undergoing phototherapy treatments utilizing UVB radiation

A STUDY ON COMPARATIVE PROFITABILITY ANALYSIS OF AMAN AND BORO RICE PRODUCTION IN SOME SELECTED AREAS OF JHALAKATHI

A Thesis Submitted to the Faculty of Agribusiness Management Sher-e-Bangla Agricultural University, Dhaka,in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE IN AGRICULTURAL ECONOMICSThis study was undertaken to assess the comparative profitability of aman and boro rice production. A total of 60 farmers (30 for aman rice growers and 30 for boro rice growers) were selected randomly from 10 villages of Jhalokati District. Survey data were collected using structured questionnaire in 2018. Tabular technique and statistical analysis were done to achieve the objectives of the study. The Cobb-Douglas production function was used in this study to determine the effects of individual inputs on aman and boro rice production. The major findings of the study were that the cultivation of aman rice and boro rice was profitable from the view point of farmers. The total return per hectare for aman rice and boro rice were Tk. 74848.6 and Tk. 141814 respectively. The gross cost of aman rice was Tk. 59315 and for boro rice it was Tk. 100430.23. Again, the net return of aman rice and boro rice were Tk. 15533.6 and Tk. 41383.77, respectively. The undiscounted Benefit Cost Ratio (BCR) were 1.26 and 1.41 for aman and boro rice production, respectively. The results indicated that boro rice production was more profitable than the aman rice production. It was also evident from the study that per hectare net returns were influenced by most of the factors included in model namely: human labor, seed, fertilizer and manure, insecticides and pesticides, power tiller, and irrigation. These factors were directly or jointly responsible for influencing per hectare net returns for aman and boro rice production. The study also showed that farmers producing aman and boro rice faced some problems, mainly related to production and marketing of the crops. It may be concluded that the farmers should be encouraged to grow more boro rice rather than aman rice as a means of increasing farm income through diversification of crop production in the area under study

Den\u27isa sokutei baiosensa to shite no tanbunshimaku shushoku sanka injiumusuzu (ITO) denkyoku no riyo to tokusei hyoka

制度:新 ; 報告番号:甲3454号 ; 学位の種類:博士(工学) ; 授与年月日:2011/10/27 ; 早大学位記番号:新577

Cellular phosphatases facilitate combinatorial processing of receptor-activated signals

<p>Abstract</p> <p>Background</p> <p>Although reciprocal regulation of protein phosphorylation represents a key aspect of signal transduction, a larger perspective on how these various interactions integrate to contribute towards signal processing is presently unclear. For example, a key unanswered question is that of how phosphatase-mediated regulation of phosphorylation at the individual nodes of the signaling network translates into modulation of the net signal output and, thereby, the cellular phenotypic response.</p> <p>Results</p> <p>To address the above question we, in the present study, examined the dynamics of signaling from the B cell antigen receptor (BCR) under conditions where individual cellular phosphatases were selectively depleted by siRNA. Results from such experiments revealed a highly enmeshed structure for the signaling network where each signaling node was linked to multiple phosphatases on the one hand, and each phosphatase to several nodes on the other. This resulted in a configuration where individual signaling intermediates could be influenced by a spectrum of regulatory phosphatases, but with the composition of the spectrum differing from one intermediate to another. Consequently, each node differentially experienced perturbations in phosphatase activity, yielding a unique fingerprint of nodal signals characteristic to that perturbation. This heterogeneity in nodal experiences, to a given perturbation, led to combinatorial manipulation of the corresponding signaling axes for the downstream transcription factors.</p> <p>Conclusion</p> <p>Our cumulative results reveal that it is the tight integration of phosphatases into the signaling network that provides the plasticity by which perturbation-specific information can be transmitted in the form of a multivariate output to the downstream transcription factor network. This output in turn specifies a context-defined response, when translated into the resulting gene expression profile.</p