Stereoisomer libraries: Total synthesis of all 16 stereoisomers of the pine sawfly sex pheromone by a fluorous mixture-synthesis approach

All 16 stereoisomers of the sex pheromone of pine sawfly (3,7,11-trimethylundecanol propanoate ester) have been synthesized on a 10- to 20-mg scale by a split-parallel fluorous mixture-synthesis approach. Spectral data obtained for all 32 compounds (16 alcohols and the corresponding propionates) matched well with published data, thereby validating the fluorous-tag encoding of diastereoisomers. This fluorous-tag encoding method is recommended for the efficient synthesis of multiple stereoisomers for spectroscopic studies, biological tests, or other structure-function relationships

On the hydrostatic approximation of the Navier-Stokes equations in a thin strip

In this paper, we first prove the global well-posedness of a scaled anisotropic Navier-Stokes system and the hydrostatic Navier-Stokes system in a 2-D striped domain with small analytic data in the tangential variable. Then we justify the limit from the anisotropic Navier-Stokes system to the hydrostatic Navier-Stokes system with analytic data

Electromagnetic energy storage and power dissipation in nanostructures

The processes of storage and dissipation of electromagnetic energy in nanostructures depend on both the material properties and the geometry. In this paper, the distributions of local energy density and power dissipation in nanogratings are investigated using the rigorous coupled-wave analysis. It is demonstrated that the enhancement of absorption is accompanied by the enhancement of energy storage both for material at the resonance of its dielectric function described by the classical Lorentz oscillator and for nanostructures at the resonance induced by its geometric arrangement. The appearance of strong local electric field in nanogratings at the geometry-induced resonance is directly related to the maximum electric energy storage. Analysis of the local energy storage and dissipation can also help gain a better understanding of the global energy storage and dissipation in nanostructures for photovoltaic and heat transfer applications

Thermally assisted skyrmions creation in Pt/Co/Ta multilayer films

N\'eel-type magnetic skyrmions in multilayer films have attracted significant amount of attention recently for their stability at room temperature and capability of motion driven by a low-density electrical current, which can be potentially applied to spintronic devices. However, the thermal effect on the formation of the skyrmions and their behavior has rarely been studied. Here, we report a study on the creation of skyrmions in [Pt/Co/Ta]10 multilayer samples at different temperatures using an in-situ Lorentz transmission electron microscopy. By imaging the magnetization reversal process from positive (negative) saturation to negative (positive) saturation, we found that the skyrmions can be created by nucleation from ferromagnetic saturation state and by breaking the labyrinth domains under certain external fields. By tuning the external fields, a maximum density of skyrmions was reached at different temperatures. The key finding is that the creation of the skyrmions in the multilayers depends critically on the temperature and thermal history

Observation of Terahertz Radiation via the Two-Color Laser Scheme with Uncommon Frequency Ratios

In the widely-studied two-color laser scheme for terahertz (THz) radiation from a gas, the frequency ratio of the two lasers is usually fixed at $\omega_2/\omega_1=$1:2. We investigate THz generation with uncommon frequency ratios. Our experiments show, for the first time, efficient THz generation with new ratios of $\omega_2/\omega_1=$1:4 and 2:3. We observe that the THz polarization can be adjusted by rotating the longer-wavelength laser polarization and the polarization adjustment becomes inefficient by rotating the other laser polarization; the THz energy shows similar scaling laws with different frequency ratios. These observations are inconsistent with multi-wave mixing theory, but support the gas-ionization model. This study pushes the development of the two-color scheme and provides a new dimension to explore the long-standing problem of the THz generation mechanism.Comment: 6 pages, 3 figure

PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.

PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway. RBM38 RNA-binding protein, also called RNPC1 and a target of p53, inhibits p53 messenger RNA (mRNA) translation, which can be reversed by GSK3 protein kinase via phosphorylation of RBM38 at serine 195. Here we showed that ectopic expression of RBM38 increases, whereas knockdown of RBM38 inhibits, PPM1D mRNA translation. Consistent with this, we found that RBM38 directly binds to PPM1D 3'-untranslated region (3'-UTR) and promotes expression of a heterologous reporter gene that carries PPM1D 3'-UTR in a dose-dependent manner. Interestingly, we showed that PPM1D directly interacts with and dephosphorylates RBM38 at serine 195. Furthermore, we showed that PPM1D modulates p53 mRNA translation and p53-dependent growth suppression through dephosphorylation of RBM38. These findings provide evidence that the crosstalk between PPM1D and RBM38, both of which are targets and modulators of p53, has a critical role in p53 expression and activity