Modeling Information Flow in Face-to-Face Meetings while Protecting Privacy

Social networks have been used to understand how information flows through an organization as well as identifying individuals that appear to have control over this information flow. Such individuals are identified as being central nodes in a graph representation of the social network and have high "betweenness" values. Rather than looking at graphs derived from email, on-line forums, or telephone connections, we consider sequences of bipartite graphs that represent face-to-face meetings between individuals, and define a new metric to identify the information elite individuals. We show that, in our simulations, individuals that attend many meetings with many different people do not always have high betweenness values, even though they seem to be the ones that control the information flow.Singapore-MIT Alliance (SMA

Micropillar compression deformation of single crystals of Fe₃Ge with the L1₂ structure

The plastic deformation behavior of single crystals of Fe₃Ge with the L1₂ structure has been investigated at room temperature as a function of crystal orientation by micropillar compression tests. In addition to slip on (010), slip on (111) is observed to occur in Fe₃Ge for the first time. The CRSS (critical resolved shear stress) for (111)[10overline{1}] slip, estimated by extrapolating the size-dependent strength variation to the ‘bulk’ size, is ~240 MPa, which is almost 6 times that (~40 MPa) for (010)[10overline{1}] slip similarly estimated. The dissociation scheme for the superlattice dislocation with b=[10overline{1}] is confirmed to be of the APB (anti-phase boundary)-type both on (010) and on (111), in contrast to the previous prediction for the SISF (superlattice intrinsic stacking fault) scheme on (111) because of the expected APB instability. While superlattice dislocations do not have any preferential directions to align when gliding on (010) (indicative of low frictional stress at room temperature), the alignment of superlattice dislocations along their screw orientation is observed when gliding on (111). This is proved to be due to thermally-activated cross-slip to form Kear-Wilsdorf locks, indicative of the occurrence of yield stress anomaly that is observed in many other L12 compounds such as Ni₃Al. Some important deformation characteristics expected to occur in Fe₃Ge (such as the absence of SISF-couple dissociation and the occurrence of yield stress anomaly) will be discussed in the light of the experimental results obtained (APB energies on (111) and (010) and CRSS values for slip on (111) and (010))

Sirtuin1 Over-Expression Does Not Impact Retinal Vascular and Neuronal Degeneration in a Mouse Model of Oxygen-Induced Retinopathy

Proliferative retinopathy is a leading cause of blindness, including retinopathy of prematurity (ROP) in children and diabetic retinopathy in adults. Retinopathy is characterized by an initial phase of vessel loss, leading to tissue ischemia and hypoxia, followed by sight threatening pathologic neovascularization in the second phase. Previously we found that Sirtuin1 (Sirt1), a metabolically dependent protein deacetylase, regulates vascular regeneration in a mouse model of oxygen-induced proliferative retinopathy (OIR), as neuronal depletion of Sirt1 in retina worsens retinopathy. In this study we assessed whether over-expression of Sirtuin1 in retinal neurons and vessels achieved by crossing Sirt1 over-expressing flox mice with Nestin-Cre mice or Tie2-Cre mice, respectively, may protect against retinopathy. We found that over-expression of Sirt1 in Nestin expressing retinal neurons does not impact vaso-obliteration or pathologic neovascularization in OIR, nor does it influence neuronal degeneration in OIR. Similarly, increased expression of Sirt1 in Tie2 expressing vascular endothelial cells and monocytes/macrophages does not protect retinal vessels in OIR. In addition to the genetic approaches, dietary supplement with Sirt1 activators, resveratrol or SRT1720, were fed to wild type mice with OIR. Neither treatment showed significant vaso-protective effects in retinopathy. Together these results indicate that although endogenous Sirt1 is important as a stress-induced protector in retinopathy, over-expression of Sirt1 or treatment with small molecule activators at the examined doses do not provide additional protection against retinopathy in mice. Further studies are needed to examine in depth whether increasing levels of Sirt1 may serve as a potential therapeutic approach to treat or prevent retinopathy

ヒトSPCA1aのクライオ電子顕微鏡解析によるゴルジ体へのCa2+/Mn2+輸送機構の解明

Tohoku University稲葉謙次課