Optimal control of nonlinear partially-unknown systems with unsymmetrical input constraints and its applications to the optimal UAV circumnavigation problem

Aimed at solving the optimal control problem for nonlinear systems with unsymmetrical input constraints, we present an online adaptive approach for partially unknown control systems/dynamics. The designed algorithm converges online to the optimal control solution without the knowledge of the internal system dynamics. The optimality of the obtained control policy and the stability for the closed-loop dynamic optimality are proved theoretically. The proposed method greatly relaxes the assumption on the form of the internal dynamics and input constraints in previous works. Besides, the control design framework proposed in this paper offers a new approach to solve the optimal circumnavigation problem involving a moving target for a fixed-wing unmanned aerial vehicle (UAV). The control performance of our method is compared with that of the existing circumnavigation control law in a numerical simulation and the simulation results validate the effectiveness of our algorithm

Structural and magnetic properties of CeZnAl3_3 single crystals

We have synthesized single crystals of CeZnAl$_3$, which is a new member of the family of the Ce-based intermetallics Ce$TX_3$ ($T$ = transition metal, $X$= Si, Ge, Al), crystallizing in the non-centrosymmetric tetragonal BaNiSn$_3$-type structure. Magnetization, specific heat and resistivity measurements all show that CeZnAl$_3$ orders magnetically below around 4.4 K. Furthermore, magnetization measurements exhibit a hysteresis loop at low temperatures and fields, indicating the presence of a ferromagnetic component in the magnetic state. This points to a different nature of the magnetism in CeZnAl$_3$ compared to the other isostructural Ce$T$Al$_3$ compounds. Resistivity measurements under pressures up to 1.8 GPa show a moderate suppression of the ordering temperature with pressure, suggesting that measurements to higher pressures are required to look for quantum critical behavior.Comment: 6 pages, 5 figure

Negative Magnetoresistance in Dirac Semimetal Cd3As2

A large negative magnetoresistance is anticipated in topological semimetals in the parallel magnetic and electric field configuration as a consequence of the nontrivial topological properties. The negative magnetoresistance is believed to demonstrate the chiral anomaly, a long-sought high-energy physics effect, in solid-state systems. Recent experiments reveal that Cd3As2, a Dirac topological semimetal, has the record-high mobility and exhibits positive linear magnetoresistance in the orthogonal magnetic and electric field configuration. However, the negative magnetoresistance in the parallel magnetic and electric field configuration remains unveiled. Here, we report the observation of the negative magnetoresistance in Cd3As2 microribbons in the parallel magnetic and electric field configuration as large as 66% at 50 K and even visible at room temperatures. The observed negative magnetoresistance is sensitive to the angle between magnetic and electrical field, robust against temperature, and dependent on the carrier density. We have found that carrier densities of our Cd3As2 samples obey an Arrhenius's law, decreasing from 3.0x10^17 cm^-3 at 300 K to 2.2x10^16 cm^-3 below 50 K. The low carrier densities result in the large values of the negative magnetoresistance. We therefore attribute the observed negative magnetoresistance to the chiral anomaly. Furthermore, in the perpendicular magnetic and electric field configuration a positive non-saturating linear magnetoresistance up to 1670% at 14 T and 2 K is also observed. This work demonstrates potential applications of topological semimetals in magnetic devices

Simplified HIV Testing and Treatment in China: Analysis of Mortality Rates Before and After a Structural Intervention.

BackgroundMultistage stepwise HIV testing and treatment initiation procedures can result in lost opportunities to provide timely antiretroviral therapy (ART). Incomplete patient engagement along the continuum of HIV care translates into high levels of preventable mortality. We aimed to evaluate the ability of a simplified test and treat structural intervention to reduce mortality.Methods and findingsIn the "pre-intervention 2010" (from January 2010 to December 2010) and "pre-intervention 2011" (from January 2011 to December 2011) phases, patients who screened HIV-positive at health care facilities in Zhongshan and Pubei counties in Guangxi, China, followed the standard-of-care process. In the "post-intervention 2012" (from July 2012 to June 2013) and "post-intervention 2013" (from July 2013 to June 2014) phases, patients who screened HIV-positive at the same facilities were offered a simplified test and treat intervention, i.e., concurrent HIV confirmatory and CD4 testing and immediate initiation of ART, irrespective of CD4 count. Participants were followed for 6-18 mo until the end of their study phase period. Mortality rates in the pre-intervention and post-intervention phases were compared for all HIV cases and for treatment-eligible HIV cases. A total of 1,034 HIV-positive participants (281 and 339 in the two pre-intervention phases respectively, and 215 and 199 in the two post-intervention phases respectively) were enrolled. Following the structural intervention, receipt of baseline CD4 testing within 30 d of HIV confirmation increased from 67%/61% (pre-intervention 2010/pre-intervention 2011) to 98%/97% (post-intervention 2012/post-intervention 2013) (all p < 0.001 [i.e., for all comparisons between a pre- and post-intervention phase]), and the time from HIV confirmation to ART initiation decreased from 53 d (interquartile range [IQR] 27-141)/43 d (IQR 15-113) to 5 d (IQR 2-12)/5 d (IQR 2-13) (all p < 0.001). Initiation of ART increased from 27%/49% to 91%/89% among all cases (all p < 0.001) and from 39%/62% to 94%/90% among individuals with CD4 count ≤ 350 cells/mm3 or AIDS (all p < 0.001). Mortality decreased from 27%/27% to 10%/10% for all cases (all p < 0.001) and from 40%/35% to 13%/13% for cases with CD4 count ≤ 350 cells/mm3 or AIDS (all p < 0.001). The simplified test and treat intervention was significantly associated with decreased mortality rates compared to pre-intervention 2011 (adjusted hazard ratio [aHR] 0.385 [95% CI 0.239-0.620] and 0.380 [95% CI 0.233-0.618] for the two post-intervention phases, respectively, for all newly diagnosed HIV cases [both p < 0.001], and aHR 0.369 [95% CI 0.226-0.603] and 0.361 [95% CI 0.221-0.590] for newly diagnosed treatment-eligible HIV cases [both p < 0.001]). The unit cost of an additional patient receiving ART attributable to the intervention was US$83.80. The unit cost of a death prevented because of the intervention was US$234.52.ConclusionsOur results demonstrate that the simplified HIV test and treat intervention promoted successful engagement in care and was associated with a 62% reduction in mortality. Our findings support the implementation of integrated HIV testing and immediate access to ART irrespective of CD4 count, in order to optimize the impact of ART

Loss to Follow-Up from HIV Screening to ART Initiation in Rural China.

BackgroundPatients who are newly screened HIV positive by EIA are lost to follow-up due to complicated HIV testing procedures. Because this is the first step in care, it affects the entire continuum of care. This is a particular concern in rural China.Objective(s)To assess the routine HIV testing completeness and treatment initiation rates at 18 county-level general hospitals in rural Guangxi.MethodsWe reviewed original hospital HIV screening records. Investigators also engaged with hospital leaders and key personnel involved in HIV prevention activities to characterize in detail the routine care practices in place at each county.Results699 newly screened HIV-positive patients between January 1 and June 30, 2013 across the 18 hospitals were included in the study. The proportion of confirmatory testing across the 18 hospitals ranged from 14% to 87% (mean of 43%), and the proportion of newly diagnosed individuals successfully initiated antiretroviral treatment across the hospitals ranged from 3% to 67% (mean of 23%). The average interval within hospitals for individuals to receive the Western Blot (WB) and CD4 test results from HIV positive screening (i.e. achieving testing completion) ranged from 14-116 days (mean of 41.7 days) across the hospitals. The shortest interval from receiving a positive EIA screening test result to receiving WB and CD4 testing and counseling was 0 day and the longest was 260 days.ConclusionThe proportion of patients newly screened HIV positive that completed the necessary testing procedures for HIV confirmation and received ART was very low. Interventions are urgently needed to remove barriers so that HIV patients can have timely access to HIV/AIDS treatment and care in rural China

Quantized massive spin 1/2 fields on static spherically symmetric wormhole spacetimes

Title from PDF of title page (University of Missouri--Columbia, viewed on October 30, 2012).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Dissertation advisors: Dr. Aigen Li and Dr. David RetzloffIncludes bibliographical references.Vita.Ph. D. University of Missouri--Columbia 2012."July 2012"Traversable wormholes have become a subject of intensive studies since 1988 when Morris and Thorne published their paper which put forward the energy conditions for traversable wormholes. A number of researchers have calculated the stress-energy tensors of different fields but failed to find one that meets the requirement of the wormhole geometry. Some others find different schemes to sustain traversable wormholes but either on the Planck scale or hypothetically on a macroscopic scale. Groves has developed a method to compute the renormalized stress-energy tensor for a quantized massive spin ½ field in a general static spherically symmetric spacetime. Using this method, I have computed the renormalized stress-energy tensors of two quantized massive spin ½ fields in four static spherically symmetric wormhole spacetimes. The results of my calculation suggest that these two fields can be considered exotic. However, due to the technical difficulties in implementing this method, a series of approximations are used in the computation in order to make the problem mathematically tractable; but it is not clear under what physical circumstances these approximations could hold. Besides, the cases that I investigated turned out to involve unphysically large energy densities. Because of these reasons, no firm physical conclusions can be drawn.Includes bibliographical reference

Aphrodisiac Use Associated with HIV Infection in Elderly Male Clients of Low-Cost Commercial Sex Venues in Guangxi, China: A Matched Case-Control Study

Background: Rising HIV infection rates have been observed among elderly people in Guangxi, China. Inexpensive aphrodisiacs are available for purchase in suburban and rural areas. This study aims to investigate the association between aphrodisiac use and increased HIV risk for middle-aged and elderly men in Guangxi. Methods: A matched case-control study of aphrodisiac use-associated HIV infection was performed among male subjects over 50 years old who were clients of low-cost commercial sex venues in Guangxi. The cases were defined as clients who were HIV-positive and two controls were selected for each case. The cases and the controls were matched on the visited sex venue, age (±3 years), number of years of purchasing sex (±3 years), and educational attainment. Subjects were interviewed and tested for HIV. Paired t-test or McNemar Chi-squared test were used to compare the characteristics between the cases and controls. A stepwise conditional logistic regression was used to identify risk factors associated with HIV infection. Findings: This study enrolled 103 cases and 206 controls. Aphrodisiac use (P = 0.02, odds ratio (OR) = 1.81, 95% CI = 1.08–3.04), never using condom during commercial sex encounter (P = 0.03, odds ratio (OR) = 1.82, 95% CI = 1.08–3.07), and lacking a stable partner (P = 0.03, odds ratio (OR) = 1.76, 95% CI = 1.05–2.98) were found to be risk factors for HIV infection among the study groups. For subjects reporting aphrodisiac use, the frequency of purchasing sex was positively correlated with the frequency of aphrodisiac use (r = 0.3; p = 0.02). Conclusions: Aphrodisiac use was significantly associated with increased HIV infection risk in men over 50 years old who purchased commercial sex in the suburban and rural areas of Guangxi. Further research and interventions should address the links between aphrodisiac use, commercial sex work, condom use, and increased HIV transmission

Design driven user study workshop for Chinese startup innovation

The paper illustrates a serial user study workshop designed for startups seeking disruptive innovation and business opportunities based on the lean process from the point view of user-centered design approach. In the Chinese market, business process moves fast. The product development cycle is relatively short which makes it easy to be interrupted and changed. Making sure the product is targeting the right marketing segment is the key to business success. Therefore, innovation has to be created on the true needs of the accurate end users. User-centered design approaches have the natural advantage to forge innovation by defining the problems of the existing products usage for the users and creating the solution that seamlessly meets the potential demands of the product users. This capability of user-centered design is extremely suitable for the early stage of the startup innovation process especially in the customer identification, market positioning, and business model generation. User study is located in the core of this user-centered innovation process. Performing a good user study ensures the product is aimed at users’ needs, which guarantees once the product is given birth it is already well-positioned in the market sharing. This is the key to the success of startup business. In this paper, a serial workshop covers the topics from what are the user study methods suitable for the lean startup innovation, how to conduct an effective interview, and how to synthesize users’ insights and find new business opportunities. By doing the workshop we try to answer the following questions which ultimately influence the nurturing process in the incubator about how design thinking can intervene to create radical innovation in startup teams: why the design driven user study is so important to the startup business? What is design thinking in the non-design background startuper’s mind and how can they incorporate the mindset in the business operation? What Chinese business environment impacts in the innovation process and how could the startups position the empathy for the users as the key for the product success