Numerical Simulation of Projectile Oblique Impact on Microspacecraft Structure

In the present study, the microspacecraft bulkhead was reduced to the double honeycomb panel, and the projectile oblique hypervelocity impact on the double honeycomb panel was simulated. The distribution of the debris cloud and the damage of a honeycomb sandwich panel were investigated when the incident angles were set to be 60°, 45°, and 30°. The results showed that as incident angle decreased, the distribution of debris cloud was increased gradually, while the maximum perforation size of the rear face sheet was firstly increased with the decrease of the incident angle and then decreased. On the other hand, the damage area and the damage degree of the front face sheet of the second honeycomb panel layer were increased with the decrease of the incident angle. Finally, the critical angle of front and rear face sheets of the honeycomb sandwich panel was obtained under oblique hypervelocity impact

Single-scan, dual-functional interferometer for fast spatiotemporal characterization of few-cycle pulses

Accurate and fast characterization of spatiotemporal information of high-intensity, ultrashort pulses is crucial in the field of strong-field laser science and technology. While conventional self-referenced interferometers were widely used to retrieve the spatial profile of the relative spectral phase of pulses, additional measurements of temporal and spectral information at a particular position of the laser beam were, however, necessary to remove the indeterminacy, which increases the system complexity. Here we report an advanced, dual-functional interferometer that is able to reconstruct the complete spatiotemporal information of ultrashort pulses with a single scan of the interferometer arm. The set-up integrates an interferometric frequency-resolved optical gating (FROG) with a radial shearing Michelson interferometer. Trough scanning one arm of the interferometer, both cross-correlated FROG trace at the central part of the laser beam and delay-dependent interferograms of the entire laser profile are simultaneously obtained, allowing a fast 3-dimensional reconstruction of few-cycle laser pulses

Retiming dynamics of harmonically modelocked laser solitons in a self-driven optomechanical lattice

Harmonic mode-locking, realized actively or passively, is an effective technique for increasing the repetition rate of lasers, with important applications in optical sampling, laser micro-machining and frequency metrology. It is critically important to understand how a harmonically mode-locked pulse train responds to external perturbations and noise, so as to make sure that it is stable and resistant to noise. Here, in a series of carefully designed experiments, we elucidate the retiming dynamics of laser pulses generated in a soliton fiber laser harmonically mode-locked at ~2 GHz to the acoustic resonance in a photonic crystal fiber (PCF) core. We characterize the self-driven optomechanical lattice along the PCF using a homodyne set-up, and reveal that each soliton undergoes damped oscillatory retiming within its trapping potential after an abrupt perturbation. In addition we show, through statistical analysis of the intra-cavity pulse spacing, how the trapping potentials are effective for suppressing timing jitter. The experimental results are well described using a dynamic model including dissipation, which provides valuable insight into the stability and noise performance of optomechanically mode-locked laser systems, and may also be useful for studying complex inter-soliton interactions

Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly

BackgroundApolipoprotein E (APOE) ε2 and APOE ε4 are the most distinct alleles among the three APOE alleles, both structurally and functionally. However, differences in cognition, brain function, and brain structure between the two alleles have not been comprehensively reported in the literature, especially in non-demented elderly individuals.MethodsA neuropsychological test battery was used to evaluate the differences in cognitive performance in five cognitive domains. Independent component analysis (ICA) and voxel-based morphometry (VBM) were used separately to analyze resting-state functional magnetic resonance imaging (rs-fMRI) data and the structure MRI data between the two groups. Finally, correlations between differential brain regions and neuropsychological tests were calculated.ResultsAPOE ε2 carriers had better cognitive performance in general cognitive, memory, attention, and executive function than APOE ε4 carriers (all p < 0.05). In ICA analyses of rs-fMRI data, the difference in the resting-state functional connectivity (rsFC) between two groups is shown in 7 brain networks. In addition, VBM analyses of the T1-weighted image revealed that APOE ε2 carriers had a larger thalamus and right postcentral gyrus volume and a smaller bilateral putamen volume than APOE ε4 carriers. Finally, differences in brain function and structure may be might be the reason that APOE ε2 carriers are better than APOE ε4 carriers in cognitive performance.ConclusionThese findings suggest that there are significant differences in brain function and structure between APOE ε2 carriers and APOE ε4 carriers, and these significant differences are closely related to their cognitive performance

Highly-stable, flexible delivery of microjoule-level ultrafast pulses in vacuumized anti-resonant hollow-core fibers for active synchronization

We demonstrate the stable and flexible light delivery of multi-{\mu}J, sub-200-fs pulses over a ~10-m-long vacuumized anti-resonant hollow-core fiber (AR-HCF), which was successfully used for high-performance pulse synchronization. Compared with the pulse train launched into the AR-HCF, the transmitted pulse train out of the fiber exhibits excellent stabilities in pulse power and spectrum, with pointing stability largely improved. The walk-off between the fiber-delivery and the other free-space-propagation pulse trains, in an open loop, was measured to be <6 fs root-mean-square (RMS) over 90 minutes, corresponding to a relative optical-path variation of <2x10-7. This walk-off can be further suppressed to ~2 fs RMS simply using an active control loop, highlighting the great application potentials of this AR-HCF set-up in large-scale laser and accelerator facilities

En bloc preparation of Drosophila brains enables high-throughput FIB-SEM connectomics

Deriving the detailed synaptic connections of an entire nervous system is the unrealized goal of the nascent field of connectomics. For the fruit fly Drosophila, in particular, we need to dissect the brain, connectives, and ventral nerve cord as a single continuous unit, fix and stain it, and undertake automated segmentation of neuron membranes. To achieve this, we designed a protocol using progressive lowering of temperature dehydration (PLT), a technique routinely used to preserve cellular structure and antigenicity. We combined PLT with low temperature en bloc staining (LTS) and recover fixed neurons as round profiles with darkly stained synapses, suitable for machine segmentation and automatic synapse detection. Here we report three different PLT-LTS methods designed to meet the requirements for FIB-SEM imaging of the Drosophila brain. These requirements include: good preservation of ultrastructural detail, high level of en bloc staining, artifact-free microdissection, and smooth hot-knife cutting to reduce the brain to dimensions suited to FIB-SEM. In addition to PLT-LTS, we designed a jig to microdissect and pre-fix the fly’s delicate brain and central nervous system. Collectively these methods optimize morphological preservation, allow us to image the brain usually at 8 nm per voxel, and simultaneously speed the formerly slow rate of FIB-SEM imaging