Decays of Zb(+) and Zb'(+) as hadronic molecules

The two newly observed hidden-bottom mesons Zb(10610) and Zb'(10650) with quantum numbers J(P) = 1(+) are considered as hadronic molecules composed of BB(*) and B(*)B(*), respectively. We give predictions for the widths of the strong two-body decays Zb(+) to Upsilon(nS) + pi(+) and Zb'(+) to Upsilon(nS) + pi(+) in a phenomenological Lagrangian approach.Comment: 9 page

Algebraic description of anharmonic stretching vibrations

A U(2) algebraic model is presented to describe stretching vibrations of XY$_n$ (n=2, 3, and 4) systems, where anharmonic interactions between the bond modes are considered. This model in a limit corresponds to an anharmonically coupled local mode model. As an example, the model for a molecule XY$_4$ is applied to recently observed spectra of methane in both gas and liquid phases, and the results obtained are in good agreement with the experiments

Possible interpretation of the ZbZ_b(10610) and ZbZ_b(10650) in a chiral quark model

Motivated by the two charged bottomonium-like resonances $Z_b$(10610) and $Z_b$(10650) newly observed by the Belle collaboration, the possible molecular states composed of a pair of heavy mesons, $B\bar{B}, B\bar{B}^*, B^*\bar{B}^*, B_s\bar{B}$, etc (in S-wave), are investigated in the framework of chiral quark models by the Gaussian expansion method. The bound states $B\bar{B}^*$ and $B^*\bar{B}^*$ with quantum numbers $I(J^{PC})=1(1^{+-})$, which are good candidates for the $Z_b(10610)$ and $Z_b(10650)$ respectively, are obtained. Other three bound states $B\bar{B}^*$ with $I(J^{PC})=0(1^{++})$, $B^*\bar{B}^*$ with $I(J^{PC})=1(0^{++}), 0(2^{++})$ are predicted. These states may be observed in open-bottom or hidden-bottom decay channel of highly excited $\Upsilon$. When extending directly the quark model to the hidden color channel of the multi-quark system, more deeply bound states are found. Future experimental search of those states will cast doubt on the validity of applying the chiral constituent quark model to the hidden color channel directly.Comment: 13 pages, 1 figure, title and some arguments in the abstract and section 5 are revised, results unchange

Genomewide association study of leprosy.

BACKGROUND: The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression. METHODS: We performed a two-stage genomewide association study by genotyping 706 patients and 1225 controls using the Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an association between the presence of leprosy and 93 single-nucleotide polymorphisms (SNPs) that were most strongly associated with the disease in the genomewide association study. Together, these replication sets comprised 3254 patients and 5955 controls. We also carried out tests of heterogeneity of the associations (or lack thereof) between these 93 SNPs and disease, stratified according to clinical subtype (multibacillary vs. paucibacillary). RESULTS: We observed a significant association (P<1.00x10(-10)) between SNPs in the genes CCDC122, C13orf31, NOD2, TNFSF15, HLA-DR, and RIPK2 and a trend toward an association (P=5.10x10(-5)) with a SNP in LRRK2. The associations between the SNPs in C13orf31, LRRK2, NOD2, and RIPK2 and multibacillary leprosy were stronger than the associations between these SNPs and paucibacillary leprosy. CONCLUSIONS: Variants of genes in the NOD2-mediated signaling pathway (which regulates the innate immune response) are associated with susceptibility to infection with M. leprae

MiR-181b sensitizes glioma cells to teniposide by targeting MDM2

Background: Although the incidence of glioma is relatively low, it is the most malignant tumor of the central nervous system. The prognosis of high-grade glioma patient is very poor due to the difficulties in complete resection and resistance to radio-/chemotherapy. Therefore, it is worth investigating the molecular mechanisms involved in glioma drug resistance. MicroRNAs have been found to play important roles in tumor progression and drug resistance. Our previous work showed that miR-181b is involved in the regulation of temozolomide resistance. In the current study, we investigated whether miR-181b also plays a role in antagonizing the effect of teniposide.Methods: MiR-181b expression was measured in 90 glioma patient tissues and its relationship to prognosis of these patients was analyzed. Cell sensitivity to teniposide was tested in 48 primary cultured glioma samples. Then miR-181b stably overexpressed U87 cells were generated. The candidate genes of miR-181b from our previous study were reanalyzed, and the interaction between miR-181b and target gene MDM2 was confirmed by dual luciferase assay. Cell sensitivity to teniposide was detected on miR-181b over expressed and MDM2 down regulated cells.Results: Our data confirmed the low expression levels of miR-181b in high-grade glioma tissues, which is related to teniposide resistance in primary cultured glioma cells. Overexpression of miR-181b increased glioma cell sensitivity to teniposide. Through target gene prediction, we found that MDM2 is a candidate target of miR-181b. MDM2 knockdown mimicked the sensitization effect of miR-181b. Further study revealed that miR-181b binds to the 3'-UTR region of MDM2 leading to the decrease in MDM2 levels and subsequent increase in teniposide sensitivity. Partial restoration of MDM2 attenuated the sensitivity enhancement by miR-181b.Conclusions: MiR-181b is an important positive regulator on glioma cell sensitivity to teniposide. It confers glioma cell sensitivity to teniposide through binding to the 3'-UTR region of MDM2 leading to its reduced expression. Our findings not only reveal the novel mechanism involved in teniposide resistance, but also shed light on the optimization of glioma treatment in the future.Department of Health Technology and Informatic

Food Supplement 20070721-GX May Increase CD34+ Stem Cells and Telomerase Activity

Few rejuvenation and antiaging markers are used to evaluate food supplements. We measured three markers in peripheral blood to evaluate the antiaging effects of a food supplement containing placental extract. Samples were evaluated for CD34+ cells, insulin-like growth factor 1 (IGF1), and telomerase activity, which are all markers related to aging. To control the quality of this food supplement, five active components were monitored. In total, we examined 44 individuals who took the food supplement from 1.2 months to 23 months; the average number of CD34+ cells was almost 6-fold higher in the experimental group compared with the control group. Food supplement intake did not change serum IGF1 levels significantly. Finally, the average telomerase activity was 30% higher in the subjects taking this food supplement. In summary, our results suggest that the placental extract in the food supplement might contribute to rejuvenation and antiaging

A single center report of MScanFit motor unit number estimation in five muscles of healthy subjects

The objective of this study was to estimate the number of motor units in 5 muscles from healthy individuals using the MScanFit program based on compound muscle action potential (CMAP) scan recordings. The examined muscles included first dorsal interosseous (FDI), abductor pollicis brevis (APB), abductor digiti minimi (ADM), second lumbrical (SL), and abductor hallucis (AH). CMAP scans were recorded from a total of 24 healthy participants. Motor unit number estimation (MUNE) values were derived from the MScanFit program. The average MUNE was 136.1 ± 31.1 (mean ± standard deviation) for the FDI, 134.9 ± 37.4 for the APB, 127.3 ± 32.3 for the ADM, 39.6 ± 8.3 for the SL, and 143.9 ± 28.9 for the AH muscles. Findings of the study provide useful information of the MScanFit MUNE for the examined muscles of healthy subjects from a single center

Application and Practice of Case Teaching in Environmental Monitoring Course

The research is supported by a Project Funded by the brand professional project form Yancheng teachers college (2016) and the teaching reform and practice of medicinal chemistry (2018YCTUJGY006) and the Flagship Major Development of Jiangsu Higher Education Institutions”(PPZY2015B113)。 Abstract The environmental monitoring course "is a practical and comprehensive university environment related strong professional required courses. In this paper, case teaching method is applied in the teaching process of environmental monitoring course, which provides a wide value space for the development of practical ability of environmental undergraduates, and at the same time Narrows the gap between theory and practice, facilitates the comprehensive application of environmental professional knowledge to solve environmental problems, and provides an effective way for the diversification and independent innovation of environmental undergraduates. The results show that case teaching can stimulate students' interest in learning, activate classroom atmosphere, and improve students' ability to analyze and solve practical environmental monitoring problems. Keywords: Case teaching; Environmental monitoring; Teaching practice DOI: 10.7176/JEES/9-11-11 Publication date: November 30th 201

Construction of Environmental Science Professional, and Improvement of Undergraduate Talent Quality

The research is supported by a Project Funded by the brand professional project form Yancheng teachers college (2016) and the teaching reform and practice of medicinal chemistry (2018YCTUJGY006) and the Flagship Major Development of Jiangsu Higher Education Institutions”(PPZY2015B113)。 Abstract Teaching quality is the lifeline of higher education, and advantages and characteristics are important conditions for the survival and development of higher education. It is the practical way to deepen the reform of talent cultivation mode and improve the overall quality of running a school. Based on the connotation of brand specialty, this paper puts forward the measures and methods of building brand specialty from the aspects of teaching staff construction, curriculum construction, teaching material construction, practical teaching and teaching management, and probes into the practice and thinking of building environmental science brand specialty and characteristic specialty. Keywords Brand major; Teaching quality; Advantages and characteristics; Construction measures DOI: 10.7176/JEP/10-33-16 Publication date: November 30th 201

Exploration on Recycling of Waste Liquid COD by Potassium Dichromate Method

The research is supported by a Project Funded by the brand professional project form Yancheng teachers college (2016) and the teaching reform and practice of medicinal chemistry (2018YCTUJGY006) and the Flagship Major Development of Jiangsu Higher Education Institutions”(PPZY2015B113)。 Abstract Potassium dichromate method was used to determine the high concentration of Hg2+, Ag+, Cr(VI), Cr3+ and H2SO4 in COD waste liquid. The waste liquid of COD was determined by potassium dichromate method, and the aluminum was used to replace Ag+ in the waste liquid to generate Ag and precipitate out, Cr(VI) was reduced to Cr3+, and then alkali neutralization, filtration and other measures were added to carry out treatment and recovery of useful substances, which not only reduced environmental pollution, but also recovered resources, with both economic and environmental benefits. Keywords Potassium dichromate method; Waste liquid; Reduction; Neutralization DOI: 10.7176/CER/11-10-08 Publication date: November 30th 201