Methodological Background of Decision Rules and Feedback Tools for Outcomes Management in Psychotherapy

Systems to provide feedback regarding treatment progress have been recognized as a promising method for the early identification of patients at risk for treatment failure in outpatient psychotherapy. The feedback systems presented in this article rely on decision rules to contrast the actual treatment progress of an individual patient and his or her expected treatment response (ETR). Approaches to predict the ETR on the basis of patient intake characteristics and previous treatment progress can be classified into two broad classes: Rationally derived decision rules rely on the judgments of experts, who determine the amount of progress that a patient has to achieve for a given treatment session to be considered “on track.” Empirically derived decision rules are based on expected recovery curves derived from statistical models applied to aggregated psychotherapy outcomes data. Examples of each type of decision rule and of feedback systems based on such rules are presented and reviewed

Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients.

BackgroundTopoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and amplification of the TOP2A gene have been associated with treatment response in colorectal and breast cancers, respectively. TOPO1 and TOP2A may be potential therapeutic targets in other malignancies as well.Summary of methodsWe analysed TOPO1 protein expression and TOP2A gene amplification in patients (n = 24,262 specimens) with diverse cancers. Since HER2 and TOP2A co-amplification have been investigated for predictive value regarding anthracycline benefit, we analysed specimens for HER2 amplification as well.ResultsOverexpressed TOPO1 protein was present in 51% of the tumours. Four percent of the tumours had TOP2A amplification, with gallbladder tumours and gastroesophageal/oesophageal tumours having rates over 10%. Overall, 4903 specimens were assessed for both TOP2A and HER2 amplification; 129 (2.6%) had co-amplification. High rates (>40%) of HER2 amplification were seen in patients with TOP2A amplification in breast, ovarian, gastroesophageal/oesophageal and pancreatic cancer.ConclusionOur data indicate that increased TOPO1 expression and TOP2A amplification, as well as HER2 co-alterations, are present in multiple malignancies. The implications of these observations regarding sensitivity to chemotherapy not traditionally administered to these tumour types merits investigation

Assessing the significance of knockout cascades in metabolic networks

Complex networks have been shown to be robust against random structural perturbations, but vulnerable against targeted attacks. Robustness analysis usually simulates the removal of individual or sets of nodes, followed by the assessment of the inflicted damage. For complex metabolic networks, it has been suggested that evolutionary pressure may favor robustness against reaction removal. However, the removal of a reaction and its impact on the network may as well be interpreted as selective regulation of pathway activities, suggesting a tradeoff between the efficiency of regulation and vulnerability. Here, we employ a cascading failure algorithm to simulate the removal of single and pairs of reactions from the metabolic networks of two organisms, and estimate the significance of the results using two different null models: degree preserving and mass-balanced randomization. Our analysis suggests that evolutionary pressure promotes larger cascades of non-viable reactions, and thus favors the ability of efficient metabolic regulation at the expense of robustness

DEVELOPMENT OF SMES IN AGRIBUSINESS OF VOJVODINA COMMUNES - STATE AND PERSPECTIVES

Agriculture as the economic sector is an important factor of economic development of Serbia and an important part of economic structure. Serbia has agrarian resources (land, climate and water) that are not used enough, and therefore, represent a significant economic potential for further development. Vojvodina is the best-developed economic region of the Republic of Serbia, with dominant role of agricultural production. The main economic potential of Vojvodina development is, among other things, the strengthening and improvement of agriculture in the private sector. Economic potential of agriculture impose the need to analyze this situation in the field of small and medium sized entrepreneurship as the bearer of the future development of agriculture in Vojvodina. Cluster analysis is a method that will determine how to group communes in Vojvodina according to the level of development of small and medium-sized enterprises in the field of agriculture, and thus get an insight into the current state of development of this sector of agriculture, as well as point out the possibilities for the future development of SMEs in agribusiness of Vojvodina.Agricultural production, Small and medium sized enterprises (SMEs), Clusters analysis, Clustering of communes in Vojvodina, Agribusiness, Community/Rural/Urban Development, Public Economics,

Superconducting film with randomly magnetized dots: A realization of the 2D XY model with random phase shifts

We consider a thin superconducting film with randomly magnetized dots on top of it. The dots produce a disordered pinning potential for vortices in the film. We show that for dots with permanent and random magnetization normal or parallel to the film surface, our system is an experimental realization of the two-dimensional XY model with random phase shifts. The low-temperature superconducting phase, that exists without magnetic dots, survives in the presence of magnetic dots for sufficiently small disorder.Comment: 5 pages, 1 figur

A proposal to detect vortices above the superconducting transition temperature

We propose a simple experiment to determine whether vortices persist above the superconducting transition temperature Tc in the pseudogap phase of high temperature cuprate superconductors. This involves using a magnetic dot to stabilize a vortex in a thin cuprate film beneath the dot. We calculate the magnetic field profile as a function of distance from the dot if a vortex is present, and discuss possible measurements that could be done to detect this. Finally, we comment on the temperature range where a stable vortex should be observable.Comment: 3 pages, 2 figure

Naphthalene crystal shape prediction from molecular dynamics simulations

We used molecular dynamics simulations to predict the steady state crystal shape of naphthalene grown from ethanol solution. The simulations were performed at constant supersaturation by utilizing a recently proposed algorithm [Perego et al., J. Chem. Phys., 142, 2015, 144113]. To bring the crystal growth within the timescale of a molecular dynamics simulation we applied Well-Tempered Metadynamics with a spatially constrained collective variable, which focuses the sampling on the growing layer. We estimated that the resulting steady state crystal shape corresponds to a rhombic prism, which is in line with experiments. Further, we observed that at the investigated supersaturations, the $\{00\bar{1}\}$ face grows in a two step two dimensional nucleation mechanism while the considerably faster growing faces $\{1\bar{1}0\}$ and $\{20\bar{1}\}$ grow new layers with a one step two dimensional nucleation mechanism