2,955 research outputs found

    The grounds of Law

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    Arguing a fortiori

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    The Symbolism of Space in African Children’s and Youth Literature

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    Cet article intitulé tente d’analyser la portée référentielle de certains espaces qu’occupe l’intrigue. Il s’agira de voir l’approche qu’en font différents auteurs et leur impact sur l’imaginaire de l’enfant. L’étude se fera sous les dimensions toponymique et topographique permettant de mieux comprendre l’enjeu de ces espaces dans la socialisation de l’enfant

    The application of clustering analysis to international private indebtedness

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    The main goal of this paper is to apply a combination of statistical and connectionist schemes to examine, via clustering analysis, private indebtedness in different countries. Thirty-nine such experiences are used. The relationship between private debts and some macroeconomic variables are discussed in some detail. The clustering performance is improved by taking advantage of specific properties and capacities of each method. The procedures are also applied to a controlled numerical example.

    O design inclusivo e o portador de deficiência visual : a estimulação sensorial na arquitectura através da terapia Snoezelen

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    Somos rodeados por arquitetura mas nem sempre a vivemos da melhor forma, nem sempre sabemos tirar o melhor partido do que nos rodeia e nem sempre o que nos rodeia é o melhor para nós nem o que nos faz mais felizes. Esta realidade é ainda maior para indivíduos portadores de deficiência. Nota-se, hoje em dia, uma crescente preocupação para que as casas, e não só os espaços comerciais e públicos, sejam acessíveis a todas as pessoas. Pensando nisto, muitos profissionais da área da Arquitectura, Engenharia e Design de Interiores, desenvolvem os seus projetos levando em conta o design universal ou inclusivo. Os princípios deste design não são exclusivos às pessoas portadoras de deficiência, a aplicação dos mesmos pode garantir, por exemplo, que uma mesma pessoa resida na mesma casa dos 0 aos 80 anos. As necessidades mudam ao longo da nossa vida. Uma casa inclusiva é por isso uma casa para toda a vida

    Legal Statements and Normative Language

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    Central and Systemic Responses to Methionine-Induced Hyperhomocysteinemia in Mice

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    Hyperhomocysteinemia has been considered a risk factor for neuropsychiatric disorders, but the mechanisms involved in this process have not been completely elucidated. the aim of this study was to analyze the influence of hyperhomocysteinemia induction by methionine supplementation considering different levels and periods of exposure in mice. for this purpose, methionine supplementation at concentrations of 0.5 and 1% were administered in water to increase homocysteinemia in male C57BL/6 mice, and was maintained for 3 time periods (2, 4 and 6 months of treatment). the results from one-carbon metabolism parameters, brain-derived neurotrophic factor (BDNF) concentrations and behavioral evaluation were compared. the 0.5% supplementation was efficient in increasing plasma homocysteine levels after 2 and 6 months. the 1% supplementation, increased plasma homocysteine after 2, 4 and 6 months. Little influence was observed in cysteine and glutathione concentrations. Frontal cortex BDNF levels showed a lack of treatment influence in all periods; only the expected decrease due to increasing age was observed. Moreover, the only behavioral alteration observed using a novel object recognition task was that which was expected with increasing age. We found that responses to hyperhomocysteinemia varied based on how it was reached, and the length of toxicity. Moreover, hyperhomocysteinemia can affect the normal pattern of one carbon metabolism during age increase in mice. These findings allow the establishment of a reliable animal model for studies in this field.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilFAPESP: 2010/00075-2FAPESP: 2011/15699-4Web of Scienc

    Statistical properties of the truncated state with random coefficients

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    In this Letter we introduce the truncated state with random coefficients (TSRC). As the coefficients of the TSRC have in principle no algorithm to produce them, our question is concerned about to what type of properties will characterize the TSRC. A general method to engineer TSRC in the running-wave domain is employed, which includes the errors due to the nonidealities of detectors and photocounts
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