In-vitro Anti-Inflammatory activity of Digera muricata Extracts

Inflammation is a process that is generally termed for pain and redness, which includes swelling. But it is defined as a heterogeneous group of processes which result in the pain and increase in vascular circulation and denaturation of protein that results in tissue degeneration. There are many synthetic drugs available to treat and relieve the inflammation. They are potent and have many side effects too. So there is an increased search for alternative means of treatment option. Thereby there was a high focus on the medicinal plants and herbs. Digera muricate, which is used to treat many diseases like analgesic activity, antidiabetic activity and anticancer activity too, this plant has proven to possess the antioxidant potential also. So there is no enough work done to verify the inflammatory potential of the plant. This was the primary consideration for this research to select the plant to prove it has anti-inflammatory potential. Having in the account that the ethical problems in the usage of lab animals, the anti-inflammatory potential of the plant was evaluated in-vitro using enzyme inhibition assays. The in-vitro models of the inflammatory activity are used for testing the anti-inflammatory activity, and the results were not different from invivo models. The extracts showed a dose based rise in the action, and the plant process a better anti-inflammatory activity than the standard drugs.</jats:p

Investigation of Arthritis Suppressing Potency of Chloris Paraguaiensis on Freund’s Adjuvant Induced Arthritis in Rats

Arthritis is a widespread disorder that occurs in elderly patients currently in the world. It is one of those disorders that affect the joints and is classified as an inflammatory disorder that is a result of immune system malfunctioning. Taking into consideration the side effects of immune suppressants that are used to treat arthritis; generally, plants are being investigated for the chemical constituents to treat the diseases. It is proved that moieties obtained from herbal sources are relatively safer and potent too. The economical methods of treating illness are using plants, and so the herbs are investigated for the treatment of arthritis. ., is one of the members of grass family which is grown wildly in tropical countries all around the world. It usually grows like a weed and can be employed for many pharmacological problems. Traditional claims are there to treat DM, Rheumatism and . Chemical constituents like , and have been isolated from the plant earlier. was selected as a subject to investigate its anti-arthritis potential in using experimental animals following the folklore claims that the plant can be used to treat arthritis. It may be due to the presence of and chemical constituents in the plant. The exact mechanism of action is to be established and the extracts in this current study showed a significantly comparable activity with that of the standard drug .</jats:p