Comparing Results of Five Glomerular Filtration Rate-Estimating Equations in the Korean General Population. MDRD Study, Revised Lund-Malmö, and Three CKD-EPI Equations

Estimated glomerular filtration rate (eGFR) is a widely used index of kidney function. Recently, new formulas such as the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations or the Lund-Malmö equation were introduced for assessing eGFR. We compared them with the Modification of Diet in Renal Disease (MDRD) Study equation in the Korean adult population. METHODS: The study population comprised 1,482 individuals (median age 51 [42-59] yr, 48.9% males) who received annual physical check-ups during the year 2014. Serum creatinine (Cr) and cystatin C (CysC) were measured. We conducted a retrospective analysis using five GFR estimating equations (MDRD Study, revised Lund-Malmö, and Cr and/or CysC-based CKD-EPI equations). Reduced GFR was defined as eGFR <60 mL/min/1.73 m². RESULTS: For the GFR category distribution, large discrepancies were observed depending on the equation used; category G1 (≥90 mL/min/1.73 m²) ranged from 7.4-81.8%. Compared with the MDRD Study equation, the other four equations overestimated GFR, and CysC-based equations showed a greater difference (-31.3 for CKD-EPI(CysC) and -20.5 for CKD-EPI(Cr-CysC)). CysC-based equations decreased the prevalence of reduced GFR by one third (9.4% in the MDRD Study and 2.4% in CKD-EPI(CysC)). CONCLUSIONS: Our data shows that there are remarkable differences in eGFR assessment in the Korean population depending on the equation used, especially in normal or mildly decreased categories. Further prospective studies are necessary in various clinical settings

Development and Validation of an Attitudinal-Profiling Tool for Patients With Asthma

This study was supported and funded by Mundipharma Pte Ltd. Online survey and statistical analysis were performed by Pei-Li Teh, Rachel Howard, Tsin-Li Chua and Jie Sun of Research Partnership Pte Ltd. Medical writing support was provided by Sen-Kwan Tay of Research2Trials Clinical Solutions Pte Ltd. The authors received honoraria from Mundipharma for their participation in the REALISE Asia Working Group meetings and discussions. Prof Price has Board membership with Mundipharma; and had received consultancy and speaker fees, grants and unrestricted funding support from Mundipharma; and payment for manuscript preparation and travel/accommodations/meeting expenses from Mundipharma. Profs Liam and David-Wang are members of the Asia-Pacific Advisory Board of Mundipharma. Profs Cho and David-Wang had received speaker fees from Mundipharma in the past. Dr Neira was an employee of Mundipharma Pte Ltd, Singapore. Ms Teh is an employee of Research Partnership Pte Ltd which conducted the REALISE Asia survey for Mundipharma. Prof Cho is a member of the Editorial Board of Allergy, Asthma & Immunology.Peer reviewedPublisher PD

How can the R.E.N.A.L. nephrometry scoring system aid management of a solid renal mass?

OBJECTIVES. To investigate use of the R.E.N.A.L. nephrometry score in relation to the choice of treatment and postoperative complications for renal masses. DESIGN. Case series. SETTING. A tertiary referral hospital in Hong Kong. PATIENTS. Data of patients undergoing nephrectomy were collected retrospectively from a clinical database and analysed. A R.E.N.A.L. nephrometry score was allocated to each renal tumour by a blinded qualified radiologist, utilising computerised imaging systems. Patient demographics, choice of surgery (radical vs partial), and approaches (open vs minimally invasive) were analysed with respect to their R.E.N.A.L. score. RESULTS. In all, 74 patients were included during the study period, of which 38 underwent partial nephrectomy and 36 underwent radical nephrectomy. No differences between the groups were found with respect to patient demographics. There were significant differences between the partial and radical nephrectomy groups in terms of their mean nephrometry score (6.9 vs 9.3, P<0.001). The mean nephrometry sum was also significantly different in the open approach versus the minimally invasive approach in patients having partial nephrectomy (7.8 vs 6.0, P=0.001). There was no difference in the postoperative 90-day morbidity and mortality in the partial nephrectomy and radical nephrectomy groups. CONCLUSIONS. The R.E.N.A.L. nephrometry score of a renal mass correlated significantly with our choice of surgery (partial vs radical) and our approach to surgery (open vs minimally invasive surgery), particularly in the partial nephrectomy group. It does not, however, correlate with postoperative complications. The nephrometry score provides a useful tool for objectively describing renal mass characteristics and enhancing better communication for the operative planning directed at renal masses.published_or_final_versio

Observation of X(3872)→J/ψγX(3872)\to J/\psi \gamma and search for X(3872)→ψ′γX(3872)\to\psi'\gamma in B decays

We report a study of $B\to (J/\psi \gamma) K$ and $B\to (\psi' \gamma)K$ decay modes using $772\times 10^{6}$ $B\bar{B}$ events collected at the \Upsilon(4S)$resonance with the Belle detector at the KEKB energy-asymmetric$e^+ e^-$collider. We observe$X(3872) \to J/\psi \gamma$and report the first evidence for$\chi_{c2} \to J/\psi \gamma$in$B\to (X_{c\bar{c}}\gamma) K$decays, while in a search for$X(3872) \to \psi' \gamma$no significant signal is found. We measure the branching fractions,$\mathcal{B}(B^{\pm} \to X(3872) K^{\pm}) \mathcal{B}(X(3872) \to J/\psi\gamma)$$=$$(1.78^{+0.48}_{-0.44}\pm 0.12)\times 10^{-6}$,$\mathcal{B} (B^{\pm} \to\chi_{c2} K^{\pm})$$=$$(1.11^{+0.36}_{-0.34} \pm 0.09) \times 10^{-5}$,$\mathcal{B}(B^{\pm} \to X(3872) K^{\pm}) \mathcal{B}(X(3872) \to \psi'\gamma)$$<$$3.45\times 10^{-6}$ (upper limit at 90% C.L.) and also provide upper limits for other searches.Comment: 6 pages, 3 figure

First Observation of Radiative B^0 -> \phi K^0 \gamma Decays and Measurements of Their Time-Dependent CP Violation

We report the first observation of the radiative decay B^0 -> \phi K^0 \gamma using a data sample of 772 x 10^6 B B-bar pairs collected at the \Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e^+e^- collider. We observe a signal of 37+/-8 events with a significance of 5.4 standard deviations including systematic uncertainties. The measured branching fraction is ${\cal B}(B^0 -> \phi K^0 \gamma) = (2.74\pm 0.60 \pm 0.32) \times 10^{-6}$, where the uncertainties are statistical and systematic, respectively. We also report the first measurements of time-dependent CP violation parameters: ${\mathcal S}_{\phi K_S^0 \gamma} = +0.74^{+0.72}_{-1.05} (stat)^{+0.10}_{-0.24} (syst)$ and ${\mathcal A}_{\phi K_S^0 \gamma} = +0.35 +/- 0.58 (stat)^{+0.23}_{-0.10} (syst)$. Furthermore, we measure ${\mathcal B}(B^+ -> \phi K^+ \gamma) = (2.48 +/- 0.30 +/- 0.24) x 10^{-6}$, ${\mathcal A}_{CP} = -0.03 +/- 0.11 +/- 0.08$ and find that the signal is concentrated in the M_{\phi K} mass region near threshold.Comment: 6 pages, 3 figures, Modified version is to be published in PRD(RC

Measurements of the Υ(10860)\Upsilon(10860) and Υ(11020)\Upsilon(11020) resonances via σ(e+e−→Υ(nS)π+π−)\sigma(e^+e^-\rightarrow\Upsilon(n{\rm S})\pi^+\pi^-)

We report new measurements of the total cross sections for $e^+e^-\to \Upsilon(n{\rm S})\pi^+\pi^-$ ($n$ = 1, 2, 3) and $e^+e^-\to b\bar b$ from a high-luminosity fine scan of the region $\sqrt{s} = 10.63$-$11.05$ GeV with the Belle detector. We observe that the $\Upsilon(n{\rm S})\pi^+\pi^-$ spectra have little or no non-resonant component and extract from them the masses and widths of $\Upsilon(10860)$ and $\Upsilon(11020)$ and their relative phase. We find $M_{10860}=(10891.1\pm3.2^{+0.6}_{-1.7})$ MeV/$c^2$ and $\Gamma_{10860}=(53.7^{+7.1}_{-5.6}\,^{+1.3}_{-5.4})$ MeV and report first measurements $M_{11020}=(10987.5^{+6.4}_{-2.5}\,^{+9.0}_{-2.1})$ MeV/$c^2$, $\Gamma_{11020}=(61^{+9}_{-19}\,^{+2}_{-20})$ MeV, and $\phi_{\rm 11020}-\phi_{\rm 10860} = (-1.0\pm0.4\,^{+1.4}_{-0.1})$ rad.Comment: University of Cincinnati preprint UCHEP-15-01, submitted to Physical Review D - Rapid Communication

Search for B+ -> l+ nu gamma decays with hadronic tagging using the full Belle data sample

We search for the decay B+ -> l+ nu gamma with l+ = e+ or mu+ using the full Belle data set of 772 x 10^6 BBbar pairs, collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We reconstruct one B meson in a hadronic decay mode and search for the B+ -> l+ nu gamma decay in the remainder of the event. We observe no significant signal within the phase space of E_gamma^sig > 1 GeV and obtain upper limits of BR(B+ -> e+ nu gamma) mu+ nu gamma) l+ nu gamma) < 3.5 x 10^-6 at 90 % credibility level.Comment: Submitted to Phys. Rev.

Study of Excited Ξc\Xi_c States Decaying into Ξc0\Xi_c^0 and Ξc+\Xi_c^+ Baryons

Using a data sample of 980 ${\rm fb}^{-1}$ of $e^+e^-$ annihilation data taken with the Belle detector operating at the KEKB asymmetric-energy $e^+e^-$ collider, we report the results of a study of excited $\Xi_c$ states that decay, via the emission of photons and/or charged pions, into $\Xi_c^0$ or $\Xi_c^+$ ground state charmed-strange baryons. We present new measurements of the masses of all members of the $\Xi_c^{\prime}$, $\Xi_c(2645)$, $\Xi_c(2790)$, $\Xi_c(2815)$, and $\Xi_c(2980)$ isodoublets, measurements of the intrinsic widths of those that decay strongly, and evidence of previously unknown transitions.Comment: Submitted to PR

Study of e+e- => B(*) B(*)-bar pi+- at sqrt(s)=10.866 GeV

We report the analysis of the three-body e+e- => B B-bar pi, B B*-bar pi, and B* B*-bar pi processes, including the first observation of the Zb+-(10610) =>[B B*-bar+c.c.]+- and Zb+-(10650) => [B*B*-bar]+- transitions. We measure visible cross sections for the three-body production of sigma_vis(e+e- => [B B*-bar+c.c.]+-pi-+=(11.2+-1.0(stat.)+-1.2(syst.)) pb and sigma_vis(e+e- => [B*B*-bar]+-pi-+)=(5.61+-0.73(stat.)+-0.66(syst.)) pb and set a 90% C.L. upper limit of sigma_vis(e+e- => [BB-bar]+-pi-+)<2.1 pb. The results are based on a 121.4 1/fb data sample collected with the Belle detector at a center-of-mass energy near the Y(5S) peak.Comment: 8 pages, 2 figure

Measurement of branching fraction and direct CPCP asymmetry in charmless B+→K+K−π+B^+ \to K^+K^- \pi^+ decays at Belle

We report a study of the charmless hadronic decay of the charged $B$ meson to the three-body final state $K^+ K^- \pi^+$. The results are based on a data sample that contains $772\times10^6$ $B \bar{B}$ pairs collected at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^+ e^-$ collider. The measured inclusive branching fraction and the direct $CP$ asymmetry are $(5.38\pm0.40\pm0.35)\times 10^{-6}$ and $-0.170\pm0.073\pm0.017$, respectively, where the first uncertainties are statistical and the second are systematic. The $K^{+}K^{-}$ invariant mass distribution of the signal candidates shows an excess in the region below $1.5$ GeV/$c^2$, which is consistent with the previous studies from BaBar and LHCb. In addition, strong evidence of a large direct $CP$ asymmetry is found in the $K^{+}K^{-}$ low-invariant-mass region.Comment: 7 pages, 3 figure