Generalizability of clinical prediction models in mental health

Concerns about the generalizability of machine learning models in mental health arise, partly due to sampling effects and data disparities between research cohorts and real-world populations. We aimed to investigate whether a machine learning model trained solely on easily accessible and low-cost clinical data can predict depressive symptom severity in unseen, independent datasets from various research and real-world clinical contexts. This observational multi-cohort study included 3021 participants (62.03% females, MAge = 36.27 years, range 15–81) from ten European research and clinical settings, all diagnosed with an affective disorder. We firstly compared research and real-world inpatients from the same treatment center using 76 clinical and sociodemographic variables. An elastic net algorithm with ten-fold cross-validation was then applied to develop a sparse machine learning model for predicting depression severity based on the top five features (global functioning, extraversion, neuroticism, emotional abuse in childhood, and somatization). Model generalizability was tested across nine external samples. The model reliably predicted depression severity across all samples (r = 0.60, SD = 0.089, p < 0.0001) and in each individual external sample, ranging in performance from r = 0.48 in a real-world general population sample to r = 0.73 in real-world inpatients. These results suggest that machine learning models trained on sparse clinical data have the potential to predict illness severity across diverse settings, offering insights that could inform the development of more generalizable tools for use in routine psychiatric data analysis

Suplementación mineral de raciones completas de iniciación para terneros I. Efecto sobre crecimiento y digestibilidad aparente de nutrientes

 Suplementación mineral de raciones completas de iniciación para terneros I. Efecto sobre crecimiento y digestibilidad aparente de nutriente

35. Commission de la Constitution des Étoiles

This Commission deals with a subject in which there is Uttle scope for organizing activity. The organization of the observations, which provide the data used in research on the constitution of the stars, is assigned to other Commissions. Theoretical investigations are a matter for individual effort, and cannot be organized by a Committee except in special cases where they involve long computations of routine character.</jats:p

35. Commission de la Constitution des étoiles

The Commission has found no opportunity for acting collectively during the last three years. The study of the constitution of the stars has been advanced by individual contributions, which it would be impracticable and undesirable to guide officially.Whilst much useful work has been done, it would be difficult to point to any outstanding development in the study of the interior of the stars during this period. But there is a prospect of great advances in the near future. From 1932 onwards experimental physicists in all countries have been largely occupied with the phenomena of transmutation of the elements, and it is clearly possible to determine in the laboratory most of the quantitative data as to the rate of the subatomic processes (especially those due to the encounters of protons and electrons with nuclei) and the consequent liberation of energy, for which astronomers have long been waiting.</jats:p

35. Commission de la Constitution des Étoiles

The Commission has found no opportunity of acting collectively in the last triennial period. Progress in the theoretical study of the constitution of the stars must be mainly a matter of individual effort; and it would be impracticable and undesirable to seek uniformity of views and methods.A brief reference may here be made to some of the problems now especially engaging attention. In this connection I would call attention to a valuable Report on “Die Theorie des Sterninnern und die Entwicklung der Sterne” (Ergebnisse der exakten Naturwissenschaften, Bd. XVI, 1937) by a member of the Commission, B. Strömgren, which deals especially with progress in the last ten years, and shows very clearly the present state of the subject.</jats:p