Development and Validation of an Attitudinal-Profiling Tool for Patients With Asthma

This study was supported and funded by Mundipharma Pte Ltd. Online survey and statistical analysis were performed by Pei-Li Teh, Rachel Howard, Tsin-Li Chua and Jie Sun of Research Partnership Pte Ltd. Medical writing support was provided by Sen-Kwan Tay of Research2Trials Clinical Solutions Pte Ltd. The authors received honoraria from Mundipharma for their participation in the REALISE Asia Working Group meetings and discussions. Prof Price has Board membership with Mundipharma; and had received consultancy and speaker fees, grants and unrestricted funding support from Mundipharma; and payment for manuscript preparation and travel/accommodations/meeting expenses from Mundipharma. Profs Liam and David-Wang are members of the Asia-Pacific Advisory Board of Mundipharma. Profs Cho and David-Wang had received speaker fees from Mundipharma in the past. Dr Neira was an employee of Mundipharma Pte Ltd, Singapore. Ms Teh is an employee of Research Partnership Pte Ltd which conducted the REALISE Asia survey for Mundipharma. Prof Cho is a member of the Editorial Board of Allergy, Asthma & Immunology.Peer reviewedPublisher PD

A Lattice Study of (Dˉ1D∗)±(\bar{D}_1 D^{*})^\pm Near-threshold Scattering

In this exploratory lattice study, low-energy near threshold scattering of the $(\bar{D}_1 D^{*})^\pm$ meson system is analyzed using lattice QCD with $N_f=2$ twisted mass fermion configurations. Both s-wave ($J^P=0^-$) and p-wave ($J^P=1^+$) channels are investigated. It is found that the interaction between the two charmed mesons is attractive near the threshold in both channels. This calculation provides some hints in the searching of resonances or bound states around the threshold of $(\bar{D}_1 D^{*})^\pm$ system.Comment: 20 pages, 15 figures, matches the version on PR

A way to measure the water quality of the LHAASO-WCDA with cosmic muon signals

The Large High Altitude Air Shower Observatory (LHAASO) is to be built at Daocheng, Sichuan Province, China. As one of the major components of the LHAASO project, a Water Cherenkov Detector Array (WCDA), with an area of 78,000~$\rm m^{2}$, contains 350,000~tons of purified water. The water transparency and its stability are critical for successful long-term operation of this project. To gain full knowledge of the water Cherenkov technique and investigate the engineering issues, a 9-cell detector array has been built at the Yangbajing site, Tibet, China. With the help of the distribution of single cosmic muon signals, the monitoring and measurement of water transparency are studied. The results show that a precision of several percent can be obtained for the attenuation length measurement, which satisfies the requirements of the experiment. In the near future, this method could be applied to the LHAASO-WCDA project

Supermassive Black Holes with High Accretion Rates in Active Galactic Nuclei. V. A New Size-Luminosity Scaling Relation for the Broad-Line Region

This paper reports results of the third-year campaign of monitoring super-Eddington accreting massive black holes (SEAMBHs) in active galactic nuclei (AGNs) between 2014-2015. Ten new targets were selected from quasar sample of Sloan Digital Sky Survey (SDSS), which are generally more luminous than the SEAMBH candidates in last two years. H$\beta$ lags ($\tau_{_{\rm H\beta}}$) in five of the 10 quasars have been successfully measured in this monitoring season. We find that the lags are generally shorter, by large factors, than those of objects with same optical luminosity, in light of the well-known $R_{_{\rm H\beta}}-L_{5100}$ relation. The five quasars have dimensionless accretion rates of $\dot{\mathscr{M}}=10-10^3$. Combining measurements of the previous SEAMBHs, we find that the reduction of H$\beta$ lags tightly depends on accretion rates, $\tau_{_{\rm H\beta}}/\tau_{_{R-L}}\propto\dot{\mathscr{M}}^{-0.42}$, where $\tau_{_{R-L}}$ is the H$\beta$ lag from the normal $R_{_{\rm H\beta}}-L_{5100}$ relation. Fitting 63 mapped AGNs, we present a new scaling relation for the broad-line region: $R_{_{\rm H\beta}}=\alpha_1\ell_{44}^{\beta_1}\,\min\left[1,\left(\dot{\mathscr{M}}/\dot{\mathscr{M}}_c\right)^{-\gamma_1}\right]$, where $\ell_{44}=L_{5100}/10^{44}\,\rm erg~s^{-1}$ is 5100 \AA\ continuum luminosity, and coefficients of $\alpha_1=(29.6_{-2.8}^{+2.7})$ lt-d, $\beta_1=0.56_{-0.03}^{+0.03}$, $\gamma_1=0.52_{-0.16}^{+0.33}$ and $\dot{\mathscr{M}}_c=11.19_{-6.22}^{+2.29}$. This relation is applicable to AGNs over a wide range of accretion rates, from $10^{-3}$ to $10^3$. Implications of this new relation are briefly discussed.Comment: 15 pages, 9 figures, 5 table, accepted for publication in The Astrophysical Journa

Knowledge-Guided Robust MRI Brain Extraction for Diverse Large-Scale Neuroimaging Studies on Humans and Non-Human Primates

Accurate and robust brain extraction is a critical step in most neuroimaging analysis pipelines. In particular, for the large-scale multi-site neuroimaging studies involving a significant number of subjects with diverse age and diagnostic groups, accurate and robust extraction of the brain automatically and consistently is highly desirable. In this paper, we introduce population-specific probability maps to guide the brain extraction of diverse subject groups, including both healthy and diseased adult human populations, both developing and aging human populations, as well as non-human primates. Specifically, the proposed method combines an atlas-based approach, for coarse skull-stripping, with a deformable-surface-based approach that is guided by local intensity information and population-specific prior information learned from a set of real brain images for more localized refinement. Comprehensive quantitative evaluations were performed on the diverse large-scale populations of ADNI dataset with over 800 subjects (55 approximately 90 years of age, multi-site, various diagnosis groups), OASIS dataset with over 400 subjects (18 approximately 96 years of age, wide age range, various diagnosis groups), and NIH pediatrics dataset with 150 subjects (5 approximately 18 years of age, multi-site, wide age range as a complementary age group to the adult dataset). The results demonstrate that our method consistently yields the best overall results across almost the entire human life span, with only a single set of parameters. To demonstrate its capability to work on non-human primates, the proposed method is further evaluated using a rhesus macaque dataset with 20 subjects. Quantitative comparisons with popularly used state-of-the-art methods, including BET, Two-pass BET, BET-B, BSE, HWA, ROBEX and AFNI, demonstrate that the proposed method performs favorably with superior performance on all testing datasets, indicating its robustness and effectiveness.published_or_final_versio

Two Photon Decays of ηc\eta_c from Lattice QCD

We present an exploratory lattice study for the two-photon decay of $\eta_c$ using $N_f=2$ twisted mass lattice QCD gauge configurations generated by the European Twisted Mass Collaboration. Two different lattice spacings of $a=0.067$fm and $a=0.085$fm are used in the study, both of which are of physical size of 2$fm$. The decay widths are found to be $1.025(5)$KeV for the coarser lattice and $1.062(5)$KeV for the finer lattice respectively where the errors are purely statistical. A naive extrapolation towards the continuum limit yields $\Gamma\simeq 1.122(14)$KeV which is smaller than the previous quenched result and most of the current experimental results. Possible reasons are discussed.Comment: 13 pages, 7 figures; matches the published versio

Limits on Light Weakly Interacting Massive Particles from the First 102.8 kg ×{\times} day Data of the CDEX-10 Experiment

We report the first results of a light weakly interacting massive particles (WIMPs) search from the CDEX-10 experiment with a 10 kg germanium detector array immersed in liquid nitrogen at the China Jinping Underground Laboratory with a physics data size of 102.8 kg day. At an analysis threshold of 160 eVee, improved limits of 8 $\times 10^{-42}$ and 3 $\times 10^{-36}$ cm$^{2}$ at a 90\% confidence level on spin-independent and spin-dependent WIMP-nucleon cross sections, respectively, at a WIMP mass ($m_{\chi}$) of 5 GeV/${c}^2$ are achieved. The lower reach of $m_{\chi}$ is extended to 2 GeV/${c}^2$.Comment: 5 pages, 4 figure

Brain explorer for connectomic analysis

Visualization plays a vital role in the analysis of multimodal neuroimaging data. A major challenge in neuroimaging visualization is how to integrate structural, functional, and connectivity data to form a comprehensive visual context for data exploration, quality control, and hypothesis discovery. We develop a new integrated visualization solution for brain imaging data by combining scientific and information visualization techniques within the context of the same anatomical structure. In this paper, new surface texture techniques are developed to map non-spatial attributes onto both 3D brain surfaces and a planar volume map which is generated by the proposed volume rendering technique, spherical volume rendering. Two types of non-spatial information are represented: (1) time series data from resting-state functional MRI measuring brain activation; (2) network properties derived from structural connectivity data for different groups of subjects, which may help guide the detection of differentiation features. Through visual exploration, this integrated solution can help identify brain regions with highly correlated functional activations as well as their activation patterns. Visual detection of differentiation features can also potentially discover image-based phenotypic biomarkers for brain diseases

Limits on light WIMPs from the CDEX-1 experiment with a p-type point-contact germanium detector at the China Jingping Underground Laboratory

We report results of a search for light Dark Matter WIMPs with CDEX-1 experiment at the China Jinping Underground Laboratory, based on 53.9 kg-days of data from a p-type point-contact germanium detector enclosed by a NaI(Tl) crystal scintillator as anti-Compton detector. The event rate and spectrum above the analysis threshold of 475 eVee are consistent with the understood background model. Part of the allowed regions for WIMP-nucleus coherent elastic scattering at WIMP mass of 6-20 GeV are probed and excluded. Independent of interaction channels, this result contradicts the interpretation that the anomalous excesses of the CoGeNT experiment are induced by Dark Matter, since identical detector techniques are used in both experiments.Comment: 5 pages, 5 figure

A Unified Approach to the Classical Statistical Analysis of Small Signals

We give a classical confidence belt construction which unifies the treatment of upper confidence limits for null results and two-sided confidence intervals for non-null results. The unified treatment solves a problem (apparently not previously recognized) that the choice of upper limit or two-sided intervals leads to intervals which are not confidence intervals if the choice is based on the data. We apply the construction to two related problems which have recently been a battle-ground between classical and Bayesian statistics: Poisson processes with background, and Gaussian errors with a bounded physical region. In contrast with the usual classical construction for upper limits, our construction avoids unphysical confidence intervals. In contrast with some popular Bayesian intervals, our intervals eliminate conservatism (frequentist coverage greater than the stated confidence) in the Gaussian case and reduce it to a level dictated by discreteness in the Poisson case. We generalize the method in order to apply it to analysis of experiments searching for neutrino oscillations. We show that this technique both gives correct coverage and is powerful, while other classical techniques that have been used by neutrino oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with published version. A few small changes, plus the two substantive changes we made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C). It was inconsistent with our actual definition in Sec. VI. 2) "Note added in proof" at end of the Conclusio