Adverse Drug Reactions and Their Impact on the Treatment of Pulmonary Tuberculosis

Background: Although there have been some reports about adverse drug reactions (ADRs) in pulmonary tuberculosis treatment, there are few detailed data and the effect of age among elderly patients on ADRs and the period of medication discontinuation due to ADRs is unknown. Purpose: We evaluated the difference in the incidence of ADRs necessitating discontinuation or a change of medication (dADR) among the different age groups and the period of discontinuation in elderly patients undergoing pulmonary tuberculosis treatment. Subjects and Methods: We conducted a retrospective medical record survey of patients who started anti-tuberculosis medication at our hospital from April 1st, 2018 to March 31st, 2020. Results: A total of 120 patients were recruited. There was no significant difference in the incidence of dADR among the different age groups every 10 years in patients ≥50 years of age (p=0.78). The median period of discontinuation was approximately 4 weeks for fever (29.5 days), approximately 3 weeks for rash (18.5 days), approximately 2 weeks for gastrointestinal disorders (16 days), and hepatocellular liver injury (15.5 days), and approximately 1 week for cholestatic liver injury (8 days) and eosinophilia (7 days). Conclusion: The incidence of dADR was not different among the age groups when patients of ≥50 years of age were compared by age. The median times of onset were 1–3 weeks after the start of treatment. The median periods of discontinuation were 1–4 weeks, and the period of discontinuation due to allergic reactions tended to be the longest</jats:p

Star formation in CALIFA survey perturbed galaxies – II. Star-formation histories and oxygen abundances

ABSTRACT Galaxy evolution is generally affected by tidal interactions. First, in this series, we reported several effects that suggest that tidal interactions contribute to the regulation of star formation (SF). To confirm this, we now compare stellar mass assembly histories and SF look-back time annular profiles between CALIFA survey tidally and non-tidally perturbed galaxies. We pair their respective star-forming regions at the closest stellar mass surface densities to reduce the influence of stellar mass. The assembly histories and annular profiles show statistically significant differences so that higher star-formation rates characterize regions in tidally perturbed galaxies. These regions underwent a more intense (re)activation of SF in the last 1 Gyr. Varying shapes of the annular profiles also reflect fluctuations between suppression and (re)activation of SF. Since gas-phase abundances used to be lower in more actively than in less actively star-forming galaxies, we further explore the plausible presence of metal-poor gas inflows able to dilute such abundances. The resolved relations of oxygen (O) abundance with stellar mass density and with total gas fraction show slightly lower O abundances for regions in tidally perturbed galaxies. The single distributions of O abundances statistically validate this. Moreover, from a metallicity model based on stellar feedback, the mass rate differentials (inflows−outflows) show statistically valid higher values for regions in tidally perturbed galaxies. These differentials, and the metal fractions from the population synthesis, suggest dominant gas inflows in these galaxies. This dominance and the differences in SF through time confirm the previously reported effects of tidal interactions on SF.</jats:p

Star formation in CALIFA survey perturbed galaxies – I. Effects of tidal interactions

ABSTRACT We explore the effects of tidal interactions on star formation (SF) by analysing a sample of CALIFA survey galaxies. The sample consists of tidally and non-tidally perturbed galaxies whose star-forming regions are paired at the closest stellar mass surface densities, even between the same galaxy types. The regions are then compared, both on the resolved star-formation main sequence (SFMS) plane and in annular property profiles. Star-forming regions in tidally perturbed galaxies exhibit flatter SFMS slopes compared to star-forming regions in non-tidally perturbed galaxies. Despite the fact that the annular profiles show star-forming regions in tidally perturbed galaxies as being mostly older, their SF properties are never reduced against those of non-tidally perturbed galaxies. Star-forming regions in non-tidally perturbed galaxies are better candidates for SF suppression (quenching). The lowered SF with increasing stellar mass density in tidally perturbed galaxies may suggest a lower dependence of SF on stellar mass. Though the SFMS slopes, either flatter or steeper, are found independent of stellar mass density, the effect of global stellar mass cannot be ignored when distinguishing between galaxy types. Since a phenomenon or property other than local/global stellar mass may be taking part in the modulation of SF, the integrated SF properties are related to the tidal perturbation parameter. We find weak, but detectable, positive correlations for perturbed galaxies suggesting that tidal perturbations induced by close companions increase the gas accretion rates of these objects.</jats:p