Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: A comparative risk assessment

Background: High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010. Methods: We used data for exposure to risk factors by country, age group, and sex from pooled analyses of population-based health surveys. We obtained relative risks for the effects of risk factors on cause-specific mortality from meta-analyses of large prospective studies. We calculated the population attributable fractions for each risk factor alone, and for the combination of all risk factors, accounting for multicausality and for mediation of the effects of BMI by the other three risks. We calculated attributable deaths by multiplying the cause-specific population attributable fractions by the number of disease-specific deaths. We obtained cause-specific mortality from the Global Burden of Diseases, Injuries, and Risk Factors 2010 Study. We propagated the uncertainties of all the inputs to the final estimates. Findings: In 2010, high blood pressure was the leading risk factor for deaths due to cardiovascular diseases, chronic kidney disease, and diabetes in every region, causing more than 40% of worldwide deaths from these diseases; high BMI and glucose were each responsible for about 15% of deaths, and high cholesterol for more than 10%. After accounting for multicausality, 63% (10·8 million deaths, 95% CI 10·1-11·5) of deaths from these diseases in 2010 were attributable to the combined effect of these four metabolic risk factors, compared with 67% (7·1 million deaths, 6·6-7·6) in 1980. The mortality burden of high BMI and glucose nearly doubled from 1980 to 2010. At the country level, age-standardised death rates from these diseases attributable to the combined effects of these four risk factors surpassed 925 deaths per 100 000 for men in Belarus, Kazakhstan, and Mongolia, but were less than 130 deaths per 100 000 for women and less than 200 for men in some high-income countries including Australia, Canada, France, Japan, the Netherlands, Singapore, South Korea, and Spain. Interpretation: The salient features of the cardiometabolic disease and risk factor epidemic at the beginning of the 21st century are high blood pressure and an increasing effect of obesity and diabetes. The mortality burden of cardiometabolic risk factors has shifted from high-income to low-income and middle-income countries. Lowering cardiometabolic risks through dietary, behavioural, and pharmacological interventions should be a part of the global response to non-communicable diseases. Funding: UK Medical Research Council, US National Institutes of Health. © 2014 Elsevier Ltd

Worldwide trends in underweight and obesity from 1990 to 2022 : a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

A list of authors and their affiliations appears online. A supplementary appendix is herewith attached.Background: Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods: We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI 2 SD above the median). Findings: From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation: The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesity.peer-reviewe

Software and computing for Run 3 of the ATLAS experiment at the LHC

The ATLAS experiment has developed extensive software and distributed computing systems for Run 3 of the LHC. These systems are described in detail, including software infrastructure and workflows, distributed data and workload management, database infrastructure, and validation. The use of these systems to prepare the data for physics analysis and assess its quality are described, along with the software tools used for data analysis itself. An outlook for the development of these projects towards Run 4 is also provided

Event mixing constraints for Bose-Einstein correlations in reactions with three particles in the final state

Bose-Einstein correlations (BEC) are widely used to gain an insight into the spatiotemporal characteristics of boson emitters. It was used for the first time in the 1950s by R. Hanbury-Brown and R. Q. Twiss[Hanbury-Brown R, Twiss R Q 1954 Phil. Mag. 45 663] in astronomy to measure the dimension of distant astronomical objects emitting photons, and hence is also known as Hanbury-Brown-Twiss effect (HBT). In nuclear and particle physics field, BEC also has important applications in the investigation of the space-time properties of subatomic reaction region, especially in elementary-particle collisions and relativistic heavy-ion collisions with large multiplicity at high energies. Its potential application in exclusive reactions with low multiplicity in the non-perturbative QCD energy region may offer complementary information like duration and size of nucleon resonances, which are generally excited by hadronic or electromagnetic probes and usually decay into the ground states accompanied by emission of identical mesons. However, the event mixing technique, which is highly adopted for BEC observations in inclusive reactions at high energies with large multiplicity cannot be directly applied to the BEC measurement in exclusive reactions with very limited multiplicity at low energies. The event mixing method produces un-correlated samples from original sample through making mixed events by randomly selecting the momenta of two bosons from different original events. It works well for the high multiplicity case because the degree of freedom of final state particles is large compared with that of the low multiplicity case. In exclusive reactions with a very limited number of identical bosons in the final state, this method is however strongly interfered by non-BEC factors such as global conservation laws and decays of resonances. Appropriate constraints are required to control the event mixing process in order to eliminate the influence of those non-BEC factors. In this study, we are trying to develop an event mixing method for BEC measurement in reactions having only three final state particles and only two identical bosons among them. For this end, five constraint modes for the event mixing are proposed and investigated via Monte Carlo simulation. Each mode employs one or a combination of the following cut conditions:1) missing mass cut (MM) that requires the missing mass of the mixed event to be equal to that of the original event; 2) polar angle consistency cut (PAC) that requires that the swapping particles should come from the same polar angle bin; 3) azimuthal angle consistency cut (AAC); 4) momentum consistency cut (MC); 5) energy upper limit cut (EU) that requires that any boson energy should not exceed a given upper limit. The double neutral pion photoproduction on the proton around 1 GeV is taken for example to demonstrate the effects of these constraints on the event mixing. In the simulation, one event sample free of BEC effects and four samples in the presence of BEC effects are generated for testing the ability for these constraints to extract BEC parameters. It is found the constraint mode using the MM and PAC cuts, and the mode employing the MM and AAC cuts, and the mode adopting the MM and the EU cuts can be used to observe BEC effects and extract BEC parameters. Among them, optimum results can be achieved by the combination of the MM and EU cuts.</jats:p