Метафорична картина світу та її місце у системі світів

Статья посвящается исследованию понятия метафорической картины мира, целесообразность выделения которой автор объясняет тем, что по аналогии с языковой и концептуальной картинами мира, термин "метафорическая картина мира" содержит информацию о сложной структуре многосмысловых значений, которые в силу своей метафорической природе гармонически объединяются.У статті йдеться про поняття метафоричної картини світу, доцільність виділення якої авторка пояснює тим, що за аналогією до мовної й концептуальної картин світу, термін "метафорична картина світу" вміщує інформацію про складну структуру багатосмислових значень, що завдяки своїй метафоричній природі гармонійно поєднуються.The article deals with the notion of metaphorical world picture connected with the general principle of conceptualization. The term "metaphorical world picture" consists of a complex structure of various meanings harmonically combined due to their metaphorical nature

Beliefs, barriers and preferences of European overweight women to adopt a healthier lifestyle in pregnancy to minimize risk of developing gestational diabetes mellitus: an explorative study

Introduction: Overweight and obese women are at high risk of developing gestational diabetes mellitus (GDM). Lifestyle programs might help curb the GDM risk. We explored beliefs, perceived barriers and preferences regarding lifestyle changes among overweight European pregnant women to help inform the development of future high quality lifestyle interventions. Methods: An explorative mixed methods, two-staged study was conducted to gather information from pregnant European women (BMI≥25kg/m2). In three European countries (Belgium, Netherlands, United Kingdom) interviews were conducted, followed by questionnaires in six other European countries (Austria, Denmark, Ireland, Italy, Poland, Spain). Content analysis, descriptive and chi square statistics were applied (p<0.05). Results: Women preferred to obtain detailed information about their personal risk. The health of their baby was major motivating factor. Perceived barriers for physical activity included pregnancy-specific issues such as tiredness and experiencing physical complaints. Insufficient time was a barrier more frequently reported by women with children. Abstaining from snacking was identified as a challenge for the majority of women, especially for those without children. Women preferred to obtain support from their partner, as well as health professionals and valued flexible lifestyle programs. Conclusions: Healthcare professionals need to inform overweight pregnant women about their personal risk, discuss lifestyle modification and assist in weight management. Lifestyle programs should be tailored to the individual, taking into account barriers experienced by overweight first-time mothers and multipara women

Author Correction: Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases.

Emmanuelle Souzeau, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this Article. This has now been corrected in both the PDF and HTML versions of the Article

Psychological sequelae following second-trimester termination of pregnancy:A longitudinal study

Introduction: The decision to terminate a pregnancy due to fetal anomalies can have a significant emotional impact, especially in second-trimester terminations. Previous studies on the psychological consequences of pregnancy termination have had limitations, and little is known about the outcomes for partners and the impact of fetal donation. Therefore, we aimed to investigate the psychological effects of second-trimester pregnancy termination and identify factors associated with outcomes in both women and men, including donation of fetal remains to science. Material and Methods: A longitudinal cohort study was conducted at the Amsterdam UMC in the Netherlands, involving women and partners who underwent termination at or before 23 weeks and 6 days of gestation. Questionnaires were administered at termination, 6 weeks, and 4 months after. We utilized validated questionnaires to assess psychological morbidity (grief, post-traumatic stress and postnatal depression and quality of life [QoL]), and factors that could potentially influence outcomes. Results: Of 241 participants, women displayed more pronounced psychological distress than men, though both groups improved over time. Four months after termination, 27.4% of women and 9.1% of men showed signs of pathological grief. Scores indicative for postnatal depression occurred in 19.8% women and 4.1% of men. A prior psychiatric history was a consistent predictor of poorer outcomes. Fetal donation to the Dutch Fetal Biobank was associated with reduced likelihood of symptoms of complicated grief four months after termination. Conclusions: Second-trimester termination of pregnancy for fetal anomalies can lead to psychological morbidity, particularly in women. However, there is a notable improvement over time for both groups. Individuals with prior psychiatric history appear more vulnerable post-termination. Also, fetal donation to science did not have a negative impact on psychological well-being.</p

Short-term forecasting of off-street parking occupancy

Information and communication technologies have opened the way to guide recent developments in the field of parking. In this paper these technologies are applied to model a decision support system that gives insight into 6-months ahead parking occupancy forecasts for 57 off-street parking locations in Amsterdam. An effect analysis was conducted into the influence of weather-, event-, parking tariff-, and public transport attributes on parking occupancy. The most influential factors on the parking occupancy were the scheduling of artistic and sports events, the addition of a public transport line, and the weather variables thunderstorm, average wind speed, temperature, precipitation, and sunshine duration. Parking tariffs did not significantly contribute to model performance, which could have been because of the lack of data and time variability in the parking tariffs of the examined parking locations. The forecasting algorithms compared were the seasonal naive model as a benchmark approach, the Box–Jenkins seasonal autoregressive integrated moving average with and without exogenous regressors (SARIMAX and SARIMA, respectively), exponential smoothing models, and the long short-term memory neural network. The SARIMAX model outperformed the other algorithms for the 6-months ahead forecasts according to the lowest root mean square error (RMSE). By including the event factor, the model improved by 24% based on the RMSE. Weather variables improved the predictive performance by 8%. Future studies could focus on the addition of more event variables, extension into an online model, and the impact of spatial–temporal features on parking occupancy

Short-term forecasting of off-street parking occupancy

Information and communication technologies have opened the way to guide recent developments in the field of parking. In this paper these technologies are applied to model a decision support system that gives insight into 6-months ahead parking occupancy forecasts for 57 off-street parking locations in Amsterdam. An effect analysis was conducted into the influence of weather-, event-, parking tariff-, and public transport attributes on parking occupancy. The most influential factors on the parking occupancy were the scheduling of artistic and sports events, the addition of a public transport line, and the weather variables thunderstorm, average wind speed, temperature, precipitation, and sunshine duration. Parking tariffs did not significantly contribute to model performance, which could have been because of the lack of data and time variability in the parking tariffs of the examined parking locations. The forecasting algorithms compared were the seasonal naive model as a benchmark approach, the Box–Jenkins seasonal autoregressive integrated moving average with and without exogenous regressors (SARIMAX and SARIMA, respectively), exponential smoothing models, and the long short-term memory neural network. The SARIMAX model outperformed the other algorithms for the 6-months ahead forecasts according to the lowest root mean square error (RMSE). By including the event factor, the model improved by 24% based on the RMSE. Weather variables improved the predictive performance by 8%. Future studies could focus on the addition of more event variables, extension into an online model, and the impact of spatial–temporal features on parking occupancy

Food sharing with friends and acquaintances: A study in preschool boys and girls

INTRODUCTION: The current study examined whether preschoolers in a (semi-)natural situation shared more food with friends or acquaintances, and whether this was different between boys and girls, older and younger children, and for preferred and non- preferred food. In order to do so, we replicated and extended the classical work of Birch and Billman in a Dutch sample. METHODS: Participants included 91 children aged between 3 to 6 years (52.7% boys, 93.4% Western European) from a middle- to upper-middle-class neighborhood in the Netherlands. RESULTS: The results revealed that children shared more non-preferred than preferred food with others. Girls gave more non-preferred food to acquaintances than to friends, whereas boys gave more to friends than to acquaintances. No effect of relationship was found for preferred food. Older children shared more food than younger children. Compared to acquaintances, friends made more active attempts to get food. Moreover, children who were not shared with were just as likely to share food as children who were shared with. DISCUSSION: Overall, only a small degree of agreement with the original study was found: Some significant findings could not be replicated, and some unconfirmed hypotheses of the original study were supported. The results underscore both the need for replications and studying the effect of social-contextual factors in natural settings

Clinicopathological and molecular characterization of inflammatory breast cancer, the prospective INFLAME registry study

Inflammatory breast cancer (IBC) is rare, with challenging diagnostics and unfavorable outcomes. Therefore, more molecular insight into IBC is needed. The comprehensive Dutch prospective INFLAME registry related IBC follow-up and treatment to histopathology and molecular analysis. Of consecutive patients, nationwide identified with newly diagnosed IBC, clinicopathological, treatment and outcome data were collected. Histopathology and RNA-sequencing were related to outcome. 125 IBC patients were enrolled. Forty-one (34%) patients had HER2 +, and 31 (25%) had triple-negative IBC. The estimated 3-year OS was 78% in M0 IBC and 29% in M1. PFS was worst in triple-negative IBC (median 7.9 vs 16.3 and 15.8 months in M1 HER2+ and HR + /HER2- IBC). DFS and OS in M0 IBC were better with guideline-concordant trimodal therapy than without (HR 0.15 and 0.15; p = 0.000005 and 0.00038). The unique prospective INFLAME confirms unfavorable IBC characteristics and outcomes. International efforts may support guideline adherence and identify IBC-specific targets.</p

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism