The Colonized and the Wrong of Colonialism

In “What's Wrong with Colonialism,” Lea Ypi argues that the distinctive wrong of colonialism should be understood as the failure of the colonial relationship to extend equal and reciprocal terms of political association to the colonized. Laura Valentini argues that Ypi's account fails. Her argument targets an ambiguity in Ypi's account of the relata of the colonial relationship. Either Ypi's view is that the members of the colonized group are, as individuals, denied an equal and reciprocal political relationship to the colonizer, or Ypi's view is that the colonized individuals form a collective agent and that it is denied an equal and reciprocal relationship to the colonizer. According to Valentini, both options face insurmountable difficulties. This paper argues that Valentini sets up a false dilemma: the third option is to think of the colonizer as relating in an unequal and nonreciprocal way to the plurality of people subjected to colonial rule. This view, I argue, avoids Valentini's objections, but it also raises new questions about how we are to understand the distinctive wrong of colonialism

Attitudinal social norms

On Bicchieri's view, social norms most centrally involve a pattern of preferences among the members of a relevant population; according to Brennan, Eriksson, Goodin, and Southwood, social norms most centrally involve patterns of normative attitudes among the members of a given group. This paper argues, first, that social norms can require attitudes as well as behaviour, and, second, that the existence of such attitudinal social norms speaks in favour of the preference-based view and against the normative attitudes-based view

Stratified social norms

This article explains how social norms can help to distinguish and understand a range of different kinds of social inequality and social hierarchy. My aim is to show how the literature on social norms can provide crucial resources to relational egalitarianism, which has made social equality and inequality into a central topic of contemporary normative political theorizing. The hope is that a more discriminating and detailed picture of different kinds of social inequality will help relational egalitarians move beyond a discussion of the justice or injustice of social equality as a single general category

Helicases FANCJ, RTEL1 and BLM Act on Guanine Quadruplex DNA in Vivo

Guanine quadruplex (G4) structures are among the most stable secondary DNA structures that can form in vitro, and evidence for their existence in vivo has been steadily accumulating. Originally described mainly for their deleterious effects on genome stability, more recent research has focused on (potential) functions of G4 structures in telomere maintenance, gene expression, and other cellular processes. The combined research on G4 structures has revealed that properly regulating G4 DNA structures in cells is important to prevent genome instability and disruption of normal cell function. In this short review we provide some background and historical context of our work resulting in the identification of FANCJ, RTEL1 and BLM as helicases that act on G4 structures in vivo. Taken together these studies highlight important roles of different G4 DNA structures and specific G4 helicases at selected genomic locations and telomeres in regulating gene expression and maintaining genome stability

Bromodeoxyuridine does not contribute to sister chromatid exchange events in normal or Bloom syndrome cells

Sister chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that SCEs are induced by DNA replication over BrdU-substituted DNA and that BrdU incorporation alone could be responsible for the high number of SCE events observed in cells from patients with Bloom syndrome (BS), a rare genetic disorder characterized by marked genome instability and high SCE frequency. Here we show using Strand-seq, a single cell DNA template strand sequencing technique, that the presence of variable BrdU concentrations in the cell culture medium and in DNA template strands has no effect on SCE frequency in either normal or BS cells. We conclude that BrdU does not induce SCEs and that SCEs detected in either normal or BS cells reflect DNA repair events that occur spontaneously.</p

Political Testimony

I argue that reliance on political testimony conflicts with two democratic values: the value of mutual justifiability and the value of equality of opportunity for political influence. Reliance on political testimony is characterized by a reliance on the assertions of others directly on a political question the citizen is asked to answer as part of a formal democratic decision procedure. Reliance on expert testimony generally, even in the context of political decision-making, does not similarly conflict with democratic values. As a consequence of the argument, citizens have a pro tanto reason to rely on their own political judgment when determining their vote, and democratic societies have a reason to only ask citizens questions they are able to answer without reliance on political testimony

A systems approach to sub-typing of rheumatoid arthritis

The current health care system is severely challenged by for instance rising costs, fewer new blockbuster drugs and increasing numbers of hospitalizations due to side effects. Especially in the area of chronic diseases the current disease fighting strategy is failing and a more personalized medicine approach is needed. In this thesis new sub-types of rheumatoid arthritis are characterized with metabolomics analysis and symptoms patterns. The sub-types are based on diagnostic knowledge from Chinese medicine. The two sub-types of RA patients were found to have differences in apoptosis regulation of T-cells and differences in urine acylcarnitine levels. A questionnaire was designed to distinguish the two sub-types and to evaluate symptom patterns of arthritis patients. In the future the response to treatment of these sub-types of patients can be studied and specific treatment can be targeted to these sub-types.LEI Universiteit LeidenArtrose & Reuma StichtingAnalyse en stochastie